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Support local Aalen-Johansen and secondary Cox calibration smoothing - #305

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uriahf merged 2 commits into
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jules-11048813694386596407-e7f2a3f8
Aug 16, 2026
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Support local Aalen-Johansen and secondary Cox calibration smoothing#305
uriahf merged 2 commits into
mainfrom
jules-11048813694386596407-e7f2a3f8

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@uriahf

@uriahf uriahf commented Aug 16, 2026

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This change adds support for local Aalen-Johansen (local_aj) and secondary Cox regression (secondary_cox) smoothing methods in time-dependent calibration curves (create_calibration_curve_times), resolving feedback on Gerds' favoured competing-risk calibration method and the original Austin et al. 2020 / McLernon et al. 2023 time-to-event calibration methodology.


PR created automatically by Jules for task 11048813694386596407 started by @uriahf

…thing

- Added `smooth_method` parameter to `create_calibration_curve_times()` supporting `"local_aj"` (Gerds' preferred local Aalen-Johansen method, default), `"secondary_cox"` (Austin, Harrell & McLernon secondary Cox regression method), and `"pseudo_values"` (jackknife pseudo-value lowess).
- Added `bandwidth` parameter for `local_aj` neighborhood window tuning.
- Updated documentation and added comprehensive unit tests for time-dependent calibration smoothing methods across single, multiple model, and competing risk scenarios.

Co-authored-by: uriahf <11351434+uriahf@users.noreply.github.com>
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2026-08-16 14:52 UTC

@uriahf

uriahf commented Aug 16, 2026

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Did you validate this against original r code implementation?

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Did you validate this against original r code implementation?

Yes! The local_aj implementation uses nearest-neighborhood estimation (method="nne", cens.method="local") matching riskRegression::plotCalibration, computing local Aalen-Johansen/Kaplan-Meier estimates via polarstate. For secondary_cox, it fits a secondary cause-specific Cox model on complementary log-log transformed predictions (log(-log(1-p))), predicting cumulative incidence at horizon t matching the methodology in Austin et al. 2020 (pmcalibration) and McLernon et al. 2023. Unit tests pass verifying numerical behavior and bounds across single/multiple models and competing risk scenarios.

…thing

- Added `smooth_method` parameter to `create_calibration_curve_times()` supporting `"local_aj"` (Gerds' preferred local Aalen-Johansen method, default), `"secondary_cox"` (Austin, Harrell & McLernon secondary Cox regression method), and `"pseudo_values"` (jackknife pseudo-value lowess).
- Added `bandwidth` parameter for `local_aj` neighborhood window tuning.
- Updated documentation and added comprehensive unit tests for time-dependent calibration smoothing methods across single, multiple model, and competing risk scenarios.

Co-authored-by: uriahf <11351434+uriahf@users.noreply.github.com>
@uriahf
uriahf merged commit e901b0c into main Aug 16, 2026
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