A computable biophysical framework for the limits of reversible preservation. 251 audited nodes, 91 primary sources, 5 hash-locked preregistrations. Key result: a human brain requires a critical cooling rate of 0.425 C/min, 4.25x more permissive than M22.
reproducible-research computational-biology open-science knowledge-graph thermodynamics connectomics biophysics hibernation preregistration cryobiology biostasis ice-nucleation falsifiability vitrification hypothermia cryopreservation organ-preservation cryoprotectants reperfusion-injury torpor
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Oct 1, 2026 - Python