antibody-engineering

BoltzGen: Toward Universal Binder Design

Propose CDR single-point mutations that rescue antibody expression without disrupting antigen binding, using bound vs. unbound ProteinMPNN logit analysis.

Small, fast, fully differentiable antibody Fv structure predictor in JAX. ~0.76M parameters, matches IgFold on CDR-H3, folds an Fv in ~0.8s on CPU.

abcat is a Python CLI/library tool that uses ANARCII as a core dependency to perform integrated analysis of antibody heavy-chain and light-chain sequences, covering both variable domains (VH, VL) and constant domains (CH1, CH2, CH3, CL).

In Silico Antibody Affinity Maturation (open source reproduction and extension of AurekaBio's Aurabind)

Automated Nextflow pipelines for high-throughput molecular dynamics screening of antibody-antigen complexes

OmniScreen-AI: Multi-modal AI drug screening for PD-L1 — small molecules, peptides & nucleic acids. RDKit · AutoDock Vina · ESM-2 · AlphaFold3 · OpenMM · MM-PBSA. Notebook-driven Colab→GPU pipeline.

Manifold Bio — independent third-party profile of a public API surface, by API Evangelist. Manifold Bio is a biotechnology company developing tissue-targeted biologic medicines. It runs a high-throughput in vivo discovery engine that pairs massively multiplexed in vivo screening — using mCode protein barcodes read out by DNA sequencing — with AI-po

Process scFv sequencing data, separating each construct into its VH chain, VL chain, and synthetic linker, then assembling and quantifying unique scFv clonotypes