Skip to content
Draft
Show file tree
Hide file tree
Changes from all commits
Commits
File filter

Filter by extension

Filter by extension

Conversations
Failed to load comments.
Loading
Jump to
Jump to file
Failed to load files.
Loading
Diff view
Diff view
4 changes: 4 additions & 0 deletions data/nextstrain/mpox/all-clades/CHANGELOG.md
Original file line number Diff line number Diff line change
@@ -1,3 +1,7 @@
## Unreleased

- Add an example mutation pattern for APOBEC3-like cytosine deamination (C>T in TCW context on both strands). It has no clustering, because these mutations are scattered across the genome

## 2026-07-07T14:07:11Z

- Breaking change: Clade Ib outbreak sh2023 now has lineages defined. Those lineages follow the same scheme as the existing clade IIb outbreak sh2017 lineage system. The root lineage is A, B might become an alias for another lineage than in IIb/sh2017. Hence, to unambiguously refer to a lineage, the outbreak must be included as well. To faciliate this, a new outbreakLineage field has been added that concatenates outbreak and lineage separated by a slash, e.g. `sh2017/B.1`. Existing `clade`, `outbreak`, and `lineage` fields remain unchanged - except that `lineage` `A` is now assigned to both clade Ib/sh2023 lineage `A` and clade IIb/sh2017 lineage `A`. The new `outbreakLineage` field is the way to unambiguously refer to a lineage.
Expand Down
25 changes: 25 additions & 0 deletions data/nextstrain/mpox/all-clades/pathogen.json
Original file line number Diff line number Diff line change
Expand Up @@ -26,6 +26,31 @@
"reference": "reference.fasta",
"treeJson": "tree.json"
},
"mutationPatterns": {
"patterns": [
{
"id": "apobec",
"name": "APOBEC3-like cytosine deamination",
"description": "APOBEC3-like cytosine deamination, observed as C>T in TCW context, and as G>A in WGA context on the opposite strand",
"events": [
{
"type": "nucSubstitution",
"ref": [
"C"
],
"qry": [
"T"
],
"motifs": [
"T(C)W"
],
"bothStrands": true
}
],
"cluster": false
}
]
},
"qc": {
"frameShifts": {
"enabled": true,
Expand Down
4 changes: 4 additions & 0 deletions data/nextstrain/mpox/clade-i/CHANGELOG.md
Original file line number Diff line number Diff line change
@@ -1,3 +1,7 @@
## Unreleased

- Add an example mutation pattern for APOBEC3-like cytosine deamination (C>T in TCW context on both strands). It has no clustering, because these mutations are scattered across the genome

## 2026-07-07T14:07:11Z

- Breaking change: Clade Ib outbreak sh2023 now has lineages defined. Those lineages follow the same scheme as the existing clade IIb outbreak sh2017 lineage system. The root lineage is A, and B might become an alias for another lineage than in IIb/sh2017. Hence, to unambiguously refer to a lineage, the outbreak must be included as well. To facilitate this, a new `outbreakLineage` field has been added that concatenates outbreak and lineage separated by a slash, e.g. `sh2023/A.1`. Existing `clade`, `outbreak`, and `lineage` fields remain unchanged - except that `lineage` `A` is now assigned to both clade Ib/sh2023 lineage `A` and (in datasets that contain it) clade IIb/sh2017 lineage `A`. The new `outbreakLineage` field is the way to unambiguously refer to a lineage.
Expand Down
25 changes: 25 additions & 0 deletions data/nextstrain/mpox/clade-i/pathogen.json
Original file line number Diff line number Diff line change
Expand Up @@ -26,6 +26,31 @@
"reference": "reference.fasta",
"treeJson": "tree.json"
},
"mutationPatterns": {
"patterns": [
{
"id": "apobec",
"name": "APOBEC3-like cytosine deamination",
"description": "APOBEC3-like cytosine deamination, observed as C>T in TCW context, and as G>A in WGA context on the opposite strand",
"events": [
{
"type": "nucSubstitution",
"ref": [
"C"
],
"qry": [
"T"
],
"motifs": [
"T(C)W"
],
"bothStrands": true
}
],
"cluster": false
}
]
},
"qc": {
"frameShifts": {
"enabled": true,
Expand Down
4 changes: 4 additions & 0 deletions data/nextstrain/mpox/clade-iib/CHANGELOG.md
Original file line number Diff line number Diff line change
@@ -1,3 +1,7 @@
## Unreleased

- Add an example mutation pattern for APOBEC3-like cytosine deamination (C>T in TCW context on both strands). It has no clustering, because these mutations are scattered across the genome

## 2026-07-07T14:07:11Z

- A new `outbreakLineage` field has been added that concatenates outbreak and lineage separated by a slash, e.g. `sh2017/B.1`. It unambiguously identifies a lineage across outbreaks: clade Ib outbreak sh2023 now also has a lineage system that reuses the same lineage names (e.g. root lineage `A`) as clade IIb outbreak sh2017. Existing `clade`, `outbreak`, and `lineage` fields remain unchanged. Clade Ib sequences are not part of this clade IIb dataset; use `nextstrain/mpox/all-clades` or `nextstrain/mpox/clade-i` for those.
Expand Down
25 changes: 25 additions & 0 deletions data/nextstrain/mpox/clade-iib/pathogen.json
Original file line number Diff line number Diff line change
Expand Up @@ -26,6 +26,31 @@
"reference": "reference.fasta",
"treeJson": "tree.json"
},
"mutationPatterns": {
"patterns": [
{
"id": "apobec",
"name": "APOBEC3-like cytosine deamination",
"description": "APOBEC3-like cytosine deamination, observed as C>T in TCW context, and as G>A in WGA context on the opposite strand",
"events": [
{
"type": "nucSubstitution",
"ref": [
"C"
],
"qry": [
"T"
],
"motifs": [
"T(C)W"
],
"bothStrands": true
}
],
"cluster": false
}
]
},
"qc": {
"frameShifts": {
"enabled": true,
Expand Down
4 changes: 4 additions & 0 deletions data/nextstrain/orthoebolavirus/bdbv/CHANGELOG.md
Original file line number Diff line number Diff line change
@@ -1,3 +1,7 @@
## Unreleased

- Add example mutation patterns for ADAR-like RNA editing (A>G on both strands) and APOBEC3-like cytosine deamination (C>T in TCW context on both strands), with simulated example sequences

## 2026-07-03T09:35:04Z

- Include open 2026 Outbreak sequences as examples;
Expand Down
Loading
Loading