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Contributor submission CczD #684

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Contributor submission CczD #684

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mite-bot Jun 12, 2026
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mite-bot Jun 12, 2026
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99 changes: 99 additions & 0 deletions mite_data/data/499abb9e-6686-11f1-8c13-d1bbc094d4fb.json
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{
"accession": "MITE9999999",
"status": "pending",
"comment": "Carbazole halogenase.",
"changelog": [
{
"version": "1",
"date": "2026-06-12",
"contributors": [
"0000-0002-3947-4444"
],
"reviewers": [
"BBBBBBBBBBBBBBBBBBBBBBBB"
],
"comment": "Add new entry for CczH"
}
],
"enzyme": {
"name": "CczH",
"description": "Halogenase",
"references": [
"doi:10.1021/acs.orglett.5c04621"
],
"databaseIds": {
"uniprot": "A0A367F480",
"genpept": "YAS72840.1"
}
},
"reactions": [
{
"tailoring": [
"Halogenation"
],
"description": "C-4 chlorination of carbazole",
"reactionSMARTS": "[#6:1]1:[#6:13]:[#6:12]2:[#6:4](:[#7:5]:[#6:6]3:[#6:11]:2:[#6:10]:[#6:9]:[#6:8]:[#6:7]:3):[#6:3]:[#6:2]:1>>[#6:1]1:[#6:13](-[Cl]):[#6:12]2:[#6:4](:[#7:5]:[#6:6]3:[#6:11]:2:[#6:10]:[#6:9]:[#6:8]:[#6:7]:3):[#6:3]:[#6:2]:1",
"reactions": [
{
"substrate": "COc1ccc2[nH]c3ccccc3c2c1",
"products": [
"COc1ccc2[nH]c3ccccc3c2c1Cl"
],
"isIntermediate": true,
"description": "C-4 chlorination of 3-methoxycarbazole"
},
{
"substrate": "Oc1ccc2[nH]c3ccccc3c2c1",
"products": [
"Oc1ccc2[nH]c3ccccc3c2c1Cl"
],
"isIntermediate": true,
"description": "C-4 chlorination of 3-hydroxycarbazole"
},
{
"substrate": "COc1ccc2[nH]c3ccc(OC)cc3c2c1",
"products": [
"COc1ccc2[nH]c3ccc(OC)c(Cl)c3c2c1"
],
"isIntermediate": true,
"description": "C-4 chlorination of 3,6-dimethoxycarbazole"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay",
"Knock-out studies"
],
"references": [
"doi:10.1021/acs.orglett.5c04621"
]
}
},
{
"tailoring": [
"Halogenation"
],
"description": "C-6 chlorination of carbazole",
"reactionSMARTS": "[#6:1]1:[#6:13]:[#6:12]2:[#6:4](:[#7:5]:[#6:6]3:[#6:11]:2:[#6:10]:[#6:9]:[#6:8]:[#6:7]:3):[#6:3]:[#6:2]:1>>[#6:1]1(-[Cl]):[#6:13]:[#6:12]2:[#6:4](:[#7:5]:[#6:6]3:[#6:11]:2:[#6:10]:[#6:9]:[#6:8]:[#6:7]:3):[#6:3]:[#6:2]:1",
"reactions": [
{
"substrate": "On1c2ccccc2c2ccccc21",
"products": [
"On1c2ccccc2c2cc(Cl)ccc21"
],
"isIntermediate": true,
"description": "C-6 chlorination of N-hydroxycarbazole"
}
],
"evidence": {
"evidenceCode": [
"Knock-out studies"
],
"references": [
"doi:10.1021/acs.orglett.5c04621"
]
}
}
]
}
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