AI application in CDC

multi-omics 多组学

Wu P, Chen D, Ding W, et al. The trans-omics landscape of COVID-19[J]. Nature communications, 2021, 12(1): 4543.

Feng G, Dong Z, Ke L, et al. AI-guided multi-omics analysis identifies NPC1-modulated susceptibility to SARS-CoV-2 infection under PM2. 5 exposure[J]. Nature Communications, 2026.

Large Language Models (LLMs) && retrieval augmented generation (RAG) 大预言模型与检索增强生成

Liberati A, Altman D G, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration[J]. Bmj, 2009, 339.

Villanueva-Miranda I, Xiao G, Xie Y. Artificial intelligence in early warning systems for infectious disease surveillance: a systematic review[J]. Frontiers in public health, 2025, 13: 1609615.

Amugongo L M, Mascheroni P, Brooks S, et al. Retrieval augmented generation for large language models in healthcare: A systematic review[J]. PLOS Digital Health, 2025, 4(6): e0000877.

Large Language Models (LLMs) && natural language processing (NLP) 大预言模型与自然语言处理

Xue D, Ye Y, Wu Y, et al. Automated Monkeypox Identification from Electronic Medical Records Using Large Language Models—Shenzhen City, Guangdong Province, China, 2023–2025[J]. China CDC Weekly, 2026, 8(20): 626.

novel pathogen discovery 新病原发现

Hou X, He Y, Fang P, et al. Using artificial intelligence to document the hidden RNA virosphere[J]. Cell, 2024, 187(24): 6929-6942. e16.

Machine learning case 机器学习实例

Nasir M, Wulandhari S A, Tenrisau D, et al. Machine learning approach to predict the dengue cases based on climate factors[J]. Window of Health: Jurnal Kesehatan, 2024: 203-214.

Zhang X, Sang X, Liu B, et al. Developing Machine Learning Prediction Model for Daily Influenza Reported Cases Using Multichannel Surveillance Data—A City, Hubei Province, China, 2023–2025[J]. China CDC Weekly, 2025, 7(44): 1396.

Deep learning case 深度学习实例

Wong K K, Segura T, Mein G, et al. Automated cooling tower detection through deep learning for Legionnaires’ disease outbreak investigations: a model development and validation study[J]. The Lancet Digital Health, 2024, 6(7): e500-e506.

review

Esteva A, Robicquet A, Ramsundar B, et al. A guide to deep learning in healthcare[J]. Nature medicine, 2019, 25(1): 24-29.

Ekundayo F. Using machine learning to predict disease outbreaks and enhance public health surveillance[J]. World J Adv Res Rev, 2024, 24(3): 794-811.

early_warning_systems

Tiggeloven T, Pfeiffer S, Matanó A, et al. The role of artificial intelligence for early warning systems: Status, applicability, guardrails, and ways forward[J]. Iscience, 2025, 28(11).

Dai K, Li X, Fang J, et al. Four-hour thunderstorm nowcasting using a deep diffusion model for satellite data[J]. Proceedings of the National Academy of Sciences, 2025, 122(51): e2517520122.

Linux服务器部署大预言模型

• ollama： https://docs.ollama.com/linux (如果命令行下载不成功可以本地浏览器下载再上传到服务器):

    curl -fsSL https://ollama.com/download/ollama-linux-amd64.tar.zst | sudo tar x -C /usr
  

  建立文件夹存储ollama对应的大模型文件

    mkdir -p /path/to/ollama/models/
  

  配置ollama.service文件，示例：

  [Unit]
  Description=Ollama Service
  After=network-online.target
  
  [Service]
  Type=simple
  
  ExecStart=/staging/ollama/bin/ollama serve
  
  User=root
  Group=root
  
  Restart=always
  RestartSec=5
  
  Environment="OLLAMA_HOST=0.0.0.0:11434"
  Environment="PATH=/path/to/ollama/bin:/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin"
  Environment="OLLAMA_MODELS=/path/to/ollama/models/"
  [Install]
  WantedBy=multi-user.target
  

• Open WebUI

  pip install open-webui
  

  配置open-webui.service,示例：

    [Unit]
    Description=Open WebUI Service
    After=network-online.target ollama.service
    
    [Service]
    Type=simple
    
    User=root
    Group=root
    
    WorkingDirectory=/path/to/open-webui
    
    ExecStart=/path/to/open-webui/bin/open-webui serve --port 3000
    
    Restart=always
    RestartSec=5
    
    Environment="PATH=/path/to/open-webui/bin:/usr/local/bin:/usr/bin"
    Environment="OLLAMA_BASE_URL=http://127.0.0.1:11434"
    
    [Install]
    WantedBy=multi-user.target
  

将以上两个service文件拷贝到/etc/systemd/system/,设置开机启动

    systemctl enable open-webui
    systemctl enable ollama
    systemctl start ollama.service
    systemctl start open-webui.service