COSMIC v3.6

README.md

@@ -18,7 +18,7 @@ Install the current stable PyPi version of SigProfilerAssignment:
 $ pip install SigProfilerAssignment
 ```
 
-If mutation calling files (MAF, VCF, or simple text files) are used as input, please install your desired reference genome as follows (available reference genomes are: GRCh37, GRCh38, mm9, mm10, rn6, and rn7):
+If mutation calling files (MAF, VCF, or simple text files) are used as input, please install your desired reference genome as follows (available reference genomes are: GRCh37, GRCh38, mm9, mm10, mm39, rn6, and rn7):
 ```python
 $ python
 from SigProfilerMatrixGenerator import install as genInstall
@@ -28,7 +28,7 @@ genInstall.install('GRCh37')
 
 ### Running
 
-Assignment of known mutational signatures to individual samples is performed using the `cosmic_fit` function. Input samples are provided using the `samples` parameter in the form of mutation calling files (VCFs, MAFs, or simple text files), segmentation files, or mutational matrices. COSMIC mutational signatures v3.5 are used as the default reference signatures, although previous COSMIC versions and custom signature databases are also supported using the `cosmic_version` and `signature_database` parameters. Results will be found in the folder specified in the `output` parameter.
+Assignment of known mutational signatures to individual samples is performed using the `cosmic_fit` function. Input samples are provided using the `samples` parameter in the form of mutation calling files (VCFs, MAFs, or simple text files), segmentation files, or mutational matrices. COSMIC mutational signatures v3.6 are used as the default reference signatures, although previous COSMIC versions and custom signature databases are also supported using the `cosmic_version` and `signature_database` parameters. Results will be found in the folder specified in the `output` parameter.
 
 ```python
 from SigProfilerAssignment import Analyzer as Analyze

SigProfilerAssignment/Analyzer.py

@@ -10,7 +10,7 @@ def decompose_fit(
     nnls_remove_penalty=0.01,
     initial_remove_penalty=0.05,
     genome_build="GRCh37",
-    cosmic_version=3.5,
+    cosmic_version=3.6,
     make_plots=True,
     collapse_to_SBS96=True,
     connected_sigs=True,
@@ -67,7 +67,7 @@ def denovo_fit(
     nnls_remove_penalty=0.01,
     initial_remove_penalty=0.05,
     genome_build="GRCh37",
-    cosmic_version=3.5,
+    cosmic_version=3.6,
     make_plots=True,
     collapse_to_SBS96=True,
     connected_sigs=True,
@@ -122,7 +122,7 @@ def cosmic_fit(
     nnls_remove_penalty=0.01,
     initial_remove_penalty=0.05,
     genome_build="GRCh37",
-    cosmic_version=3.5,
+    cosmic_version=3.6,
     make_plots=True,
     collapse_to_SBS96=True,
     connected_sigs=True,

SigProfilerAssignment/DecompositionPlots/PlotDecomposition.py

@@ -77,7 +77,7 @@
 def install_cosmic_plots(
     context_type="96",
     genome_build="GRCh37",
-    cosmic_version="3.5",
+    cosmic_version="3.6",
     exome=False,
     volume=None,
 ):
@@ -898,7 +898,7 @@ def run_PlotDecomposition(
     output_path,
     project,
     mtype,
-    cosmic_version="3.5",
+    cosmic_version="3.6",
     genome_build="GRCh37",
     exome=False,
     custom_text=None,
@@ -1042,7 +1042,7 @@ def run_PlotSSDecomposition(
     project,
     context_type,
     genome_build="GRCh37",
-    cosmic_version="3.5",
+    cosmic_version="3.6",
     custom_text=None,
     exome=False,
     volume=None,

SigProfilerAssignment/controllers/cli_controller.py

@@ -47,13 +47,13 @@ def parse_arguments_common(args: List[str], description: str) -> argparse.Namesp
     parser.add_argument(
         "--genome_build",
         default="GRCh37",
-        help="The reference genome build (default: GRCh37). Supported genomes: {GRCh37, GRCh38, mm9, mm10, rn6}.",
+        help="The reference genome build (default: GRCh37). Supported genomes: {GRCh37, GRCh38, mm9, mm10, mm39, rn6, rn7}.",
     )
     parser.add_argument(
         "--cosmic_version",
         type=float,
-        default=3.5,
-        help="COSMIC version (default: 3.5). Valid options: {1, 2, 3, 3.1, 3.2, 3.3, 3.4, 3.5}.",
+        default=3.6,
+        help="COSMIC version (default: 3.6). Valid options: {1, 2, 3, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6}.",
     )
     parser.add_argument(
         "--make_plots",

SigProfilerAssignment/data/Reference_Signatures/GRCh37/COSMIC_v3.6_CN_GRCh37.txt

@@ -0,0 +1,49 @@
+Type	CN1	CN2	CN3	CN4	CN5	CN6	CN7	CN8	CN9	CN10	CN11	CN12	CN13	CN14	CN15	CN16	CN17	CN18	CN19	CN20	CN21	CN22	CN23	CN24	CN25	CN26
+0:homdel:0-100kb	0.001795054	0.002237674	0.064044243	0.00096628	0.02582249	0.0034925	0.0	0.00021626	0.008181842	0.00779524	0.00161374	0.02309338	0.00224368	0.0121477	0.0067438	0.0036673	0.00136668	0.00110894	0.00591472	4.08e-05	5.5e-07	0.266866171	0.24410253	0.000371716	0.006074244	0.00922234
+0:homdel:100kb-1Mb	0.003807104	0.007195788	0.00640384	0.00021955	0.02499357	0.007550309	0.0	0.000720975	0.020999189	0.03122532	0.0059027	0.052724771	0.03467842	0.03389276	0.02652628	0.00109281	0.00143123	0.00303045	0.00677398	0.00017845	0.00022928	0.02038467	0.02413956	0.000760546	0.009107288	0.01269433
+0:homdel:>1Mb	0.002436746	0.003837108	0.013033431	6.12e-05	0.0038887	0.00133617	0.0	0.00026934	0.009009219	0.00455881	0.00313081	0.0068661	0.01814564	4.4e-07	0.00524487	0.04053983	0.0014533	0.0007584	0.0041105	0.00011722	0.00135207	0.001282235	0.00355824	0.000575594	0.004061581	0.00522882
+1:LOH:0-100kb	0.002840449	0.002826536	0.062213582	0.056150771	0.015829115	0.00595583	0.00011082	0.000950405	0.018583652	0.00879753	0.0027543	0.02182354	0.00284705	0.00129939	0.00763888	0.00142666	0.00211427	0.0015556	0.01041569	0.00050182	0.0002482	0.02147356	0.13028998	0.000635022	0.142313643	0.00718471
+1:LOH:100kb-1Mb	0.012263057	0.006323915	0.012614821	0.247798925	0.02654494	0.010520759	0.0050408	0.00728363	0.130807872	0.03974523	0.0062317	0.065977011	0.02886982	0.01293743	0.00252662	0.00580905	0.00507205	0.00141876	0.064293751	0.00081924	0.0123588	0.034899515	0.0768859	0.004601138	0.310351003	0.02106504
+1:LOH:1Mb-10Mb	0.019163418	0.001023764	0.019283461	0.083369342	0.00135803	0.00099151	7.44e-05	0.002204905	0.159949199	0.01091525	0.01775071	0.00423455	0.12860718	2.02e-05	1e-07	0.00343106	0.0186884	0.00028103	0.03777062	0.00624116	0.05642821	0.024426895	0.03485188	0.004307654	0.026957401	0.01530544
+1:LOH:10Mb-40Mb	0.047297757	0.000483364	0.0087199	0.00010096	0.000573685	0.00040994	2e-08	0.00366415	0.076229355	0.00290428	0.00184154	4.03e-05	0.1541978	1.4e-07	4.4e-07	0.00204512	0.00550295	8e-08	0.02105378	0.00283775	0.04607252	0.003555775	0.02090447	0.002622552	0.002556706	0.01289555
+1:LOH:>40Mb	0.073645999	0.000124322	0.00409212	0.00230378	8.1e-05	0.00017917	0.0	0.006089315	0.027000693	0.00148398	5.75e-05	4.64e-06	0.21568204	1.87e-06	0.0003073	0.00064424	1.34e-06	1.65e-06	0.00174097	1.2e-05	0.01887089	0.002450425	0.00226301	0.00227007	0.000974623	0.00805582
+2:LOH:0-100kb	0.001187984	0.002488917	0.00138849	0.0141463	0.0133515	0.019251449	0.00277607	0.01111584	0.004119057	0.00635726	0.00148901	0.00590696	5.69e-05	0.00762253	0.00228469	0.00067984	0.00055893	0.00273632	0.00566334	0.00060974	0.00070358	0.00299482	4e-08	0.003253376	0.010419214	0.0204730999999999
+2:LOH:100kb-1Mb	0.004303102	0.019464869	0.033835141	0.040089381	0.255496412	0.177292158	0.0045434	0.0222829	0.013774233	0.087823539	0.01694496	0.080936481	0.02909678	0.00707926	0.0215107	0.01758306	0.00062269	0.0065518	0.054896441	0.00134094	0.06234918	0.073916265	0.00033402	0.270457816	9.09e-05	0.06078213
+2:LOH:1Mb-10Mb	0.004438013	0.033551543	0.018990581	0.00618009	0.264575824	0.116382852	0.00457336	0.00829832	0.011594393	0.131910499	0.0439202	0.132671041	0.03957572	0.02585003	0.0088679	0.01162738	0.084442329	0.00018517	0.117067141	0.01443458	0.03913487	0.079960515	0.00178993	0.2022044	0.000384815	0.17442198
+2:LOH:10Mb-40Mb	0.00431859	0.052291175	0.00267497	0.00024516	0.067065891	0.00632481	4.11e-05	0.00115938	0.004945152	0.087069829	0.02467614	0.176727892	0.01185966	0.09336807	0.00201416	0.00291477	0.088483279	0.00015695	0.04188772	0.0096627	0.00129894	0.01765472	0.00517329	0.011946964	0.000350439	0.11811706
+2:LOH:>40Mb	0.012215654	0.06737476	8.24e-05	0.00241502	0.01961649	0.00026093	0.0	0.00013197	0.002407305	0.01593395	0.01121149	0.136224511	8.5e-05	0.55221235	3.3e-07	0.00170498	0.0075038	7.26e-05	0.03389879	0.00049936	0.00195567	0.00590559	0.0	0.0050787	0.000750494	0.02060637
+3-4:LOH:0-100kb	0.001379947	0.002717402	0.0027191	0.01402566	0.005480255	0.00505183	0.00420447	0.00956472	0.001833529	0.00743812	0.00158209	0.00930253	0.00057156	0.00141835	0.00197133	0.00093853	0.00267395	0.00226406	0.01388264	0.002561	0.00053506	0.001204125	0.00072698	0.000685112	0.000296679	0.01506038
+3-4:LOH:100kb-1Mb	0.001667853	0.013819445	0.023811221	0.01144021	0.02685577	0.013510279	0.0023279	0.004662895	0.002848605	0.068455299	0.0482419	0.03071852	0.00817896	0.00688559	0.01163685	0.02159759	0.02375527	0.01402709	0.01258572	0.02182453	2.09e-05	0.00824588	0.00079858	0.011435602	8.69e-07	0.03445676
+3-4:LOH:1Mb-10Mb	0.001514284	0.012471389	0.034367671	0.00010785	0.029519046	0.00409704	0.00021573	0.00349215	0.00344351	0.096466639	0.156264722	0.04005227	0.01705423	0.00687404	0.04837325	0.043701	0.094627309	0.05963823	0.00110793	0.02055562	0.00277049	0.010814625	0.00034028	0.005760546	2.04e-05	0.09684851
+3-4:LOH:10Mb-40Mb	0.000102203	0.010631239	0.021891551	1e-07	0.00455209	5.61e-05	7.9e-07	0.002194095	0.001390007	0.04754809	0.055274161	0.02606018	0.00759605	0.00128688	0.16721937	0.0329184	0.051836149	0.07185141	0.00278047	0.0022434	0.00027444	0.00356193	0.0007486	0.00075315	1.85e-05	0.06548568
+3-4:LOH:>40Mb	0.007367609	0.017426922	0.025294791	1.3e-07	0.00073589	0.00032855	6.74e-06	0.003399115	0.001198601	0.01319828	0.03509218	0.01659015	0.00381337	7.35e-05	0.37328855	0.19071235	0.00224311	0.05059881	0.00421117	0.00094554	0.00172068	0.005440365	0.00044828	0.000533794	8.21e-05	0.02410321
+5-8:LOH:0-100kb	0.000351298	0.001689411	5.3e-07	0.025527171	0.00066453	0.00048949	0.00552275	0.010770475	0.000375937	0.00260391	0.00501223	0.00578286	0.00294361	0.00316274	0.00348453	0.0034784	0.00128554	0.00482129	2.59e-05	0.00091844	2.5e-07	0.000741885	1.4e-07	0.000227864	0.0008887	0.0070388799999999
+5-8:LOH:100kb-1Mb	0.000212107	0.003416253	0.00256956	0.00169273	0.000652505	0.00031046	0.00682636	0.009675285	0.000836165	0.02207809	0.04217432	0.00208666	0.00123595	6.47e-06	0.01942632	0.00980644	0.00726579	0.02136849	8.14e-06	0.00241053	5.46e-05	0.000521815	1.6e-06	0.000577402	0.00039106	0.00584006
+5-8:LOH:1Mb-10Mb	0.000207783	0.004495306	0.0055492	1.9e-07	0.000278185	0.00021435	6.78e-05	0.00215584	0.000661617	0.02022345	0.073571791	0.00322838	0.0061044	2.3e-07	0.02016289	0.01073875	0.01836005	0.04681185	1.58e-05	0.00524955	1.67e-05	0.001434025	1.53e-05	0.000810458	0.000206542	0.01292003
+5-8:LOH:10Mb-40Mb	9.97e-05	0.002756042	7.1e-07	1.31e-05	0.000125705	0.00011771	0.0	0.001022835	0.000376486	0.00679665	0.01532663	0.00163617	0.00077852	8.96e-06	0.01347168	0.00622641	0.00502947	0.02208834	0.00068876	0.00029923	3.6e-07	0.000605405	1.4e-07	0.00011455	1.43e-05	0.00371877
+5-8:LOH:>40Mb	0.000331938	0.010089624	0.00535955	1.4e-07	9.88e-05	0.00030406	4.93e-05	0.00145962	0.000382635	0.00017289	0.00347323	0.00110016	0.00162804	0.00572642	0.06422257	0.01067078	1.29e-06	0.00536994	0.00012041	0.00012116	3.9e-05	0.002408955	1.83e-05	8.7e-05	1.1e-07	0.00389208
+9+:LOH:0-100kb	0.000133995	0.000520196	7.1e-07	1.06e-05	0.001312595	0.00493142	0.00632901	0.022043315	0.000759424	0.00018531	0.00062013	0.00048688	4.45e-05	1.46e-06	0.00300605	0.00384194	0.00012468	0.00241473	0.00107168	0.00014531	3.6e-07	0.002498515	1.4e-07	0.00049292	0.000873954	0.0015796
+9+:LOH:100kb-1Mb	0.000411988	0.000668643	0.00216196	2.8e-07	0.00330625	0.00545954	0.02139771	0.028381515	0.001234374	0.0029966	0.01160088	0.00011188	0.00344403	8.5e-07	0.00785032	0.0047163	5.3e-05	0.01211638	0.00117826	0.00085741	3.97e-06	0.00067448	3.28e-05	0.000376804	0.001337021	0.00140594
+9+:LOH:1Mb-10Mb	0.00020077	0.000828997	0.0022066	2.8e-07	0.000649225	0.00086716	0.01464548	0.00809473	0.000574562	0.00365022	0.02224864	0.00012019	0.00163639	1.1e-05	0.00480835	2.35e-06	1.37e-05	0.01534961	1.6e-07	0.00046208	8.48e-05	0.0010781	1.4e-07	0.000121946	5.59e-05	0.00128556
+9+:LOH:10Mb-40Mb	6.51e-06	0.000350903	0.0021129	2.8e-07	1.51e-05	1.27e-05	6.1e-07	2.53e-05	1.02e-05	0.00044558	0.00252885	6.14e-05	6.1e-07	1.59e-06	0.00234481	2.35e-06	5.29e-05	0.0009794	1.6e-07	0.0001094	1.59e-05	9.02e-05	1.4e-07	5.71e-06	3.14e-05	0.00017789
+9+:LOH:>40Mb	2.76e-06	0.000712768	0.00092755	2.8e-07	1.23e-05	3.4e-05	2e-08	0.00011179	4.55e-06	9e-08	0.00148788	1.65e-05	0.00013687	1.23e-06	0.00380205	0.00333085	2.9e-07	7.7e-07	4.66e-05	1.07e-05	5.38e-05	0.00010431	1.5e-07	2.68e-06	4.97e-08	3.2e-07
+2:het:0-100kb	0.000126855	0.001077283	0.020851501	0.00018321	0.00173387	0.0035614	0.00021658	0.0010385	0.002813763	0.00213926	0.0	0.00068448	0.00242738	0.00144658	1.04e-05	0.00266672	0.00038608	0.00029759	0.0031181	0.00053199	0.00030646	0.00313745	0.00205934	0.000280432	0.059739079	0.03686276
+2:het:100kb-1Mb	0.002392692	0.001448575	0.01137198	0.0009306	0.00835966	0.00180746	0.00209292	0.0008892	0.057456734	0.00460283	1e-08	0.00313133	0.00710641	0.0003872	6.6e-05	0.00197375	0.0001888	3.02e-05	0.0312283	0.00464189	0.01868806	0.0309067	0.02112224	0.020441704	0.311415627	0.00281572
+2:het:1Mb-10Mb	0.017226427	0.000571468	0.023632351	0.00124271	0.04798882	0.008628749	0.00016457	0.002329035	0.159920321	0.0006929	0.0	0.00410482	0.06241927	0.00011283	1.17e-06	0.00185384	0.00087384	1.1e-07	0.0164266	0.00278654	0.12630567	0.161346311	0.12925873	0.196033892	0.055182533	0.00334658
+2:het:10Mb-40Mb	0.112043886	0.00040127	0.024327821	0.00653021	0.04018991	0.008931519	0.0	0.00267494	0.129543643	0.00078362	3.93e-06	0.0010782	0.06807839	1.03e-06	0.00020074	0.00136271	0.00061789	3.4e-07	0.00452687	0.0013967	0.20984675	0.108768015	0.26664244	0.179726574	0.02332703	0.00378465
+2:het:>40Mb	0.647548237	1.62e-06	0.022788761	0.047210821	6.15e-07	0.00200753	3.1e-07	0.002161405	0.006767871	6e-08	8e-08	4.3e-07	0.06958505	2.46e-06	6.46e-05	7.5e-07	0.0	3.2e-07	4.6e-07	8.15e-06	0.07227018	0.00087765	0.01902544	0.01829589	0.012052462	5.248e-05
+3-4:het:0-100kb	0.000986437	0.001301613	0.016759401	0.028397721	0.004295095	0.009499469	0.00362014	0.013551545	0.006686778	0.00557084	0.00042229	0.00495	0.00027983	0.00058958	8.1e-05	0.00179605	0.00015917	0.00117086	0.01701046	0.00077956	0.00800623	0.001840025	0.0007458	0.00050524	0.005072116	0.11355659
+3-4:het:100kb-1Mb	0.003623147	0.01521748	0.042647992	0.203288654	0.027386325	0.205503726	0.06003456	0.04139118	0.067471318	0.04177622	6.5e-06	0.00936991	0.01942203	0.00815141	5.51e-06	0.02323495	0.00188043	0.0120089	0.205701382	0.08651517	0.27819348	0.02145428	0.00157867	0.008474694	0.007390987	0.028357
+3-4:het:1Mb-10Mb	0.001734587	0.05815643	0.027620611	0.055675991	0.015401125	0.233334904	0.12143735	0.026193135	0.043510864	0.086956359	0.01763335	0.01812126	0.02082491	0.01439058	3.82e-05	0.01723295	0.185038198	0.0	0.122306121	0.33498798	0.03014244	0.044882975	0.00634558	0.015763968	0.000560018	0.00195127
+3-4:het:10Mb-40Mb	0.003009542	0.135200883	0.018505441	0.00340995	0.02038458	0.062990656	0.00493032	0.00495607	0.007530375	0.067579949	0.00761337	0.100679891	0.01275603	0.03273598	0.00189743	0.00618312	0.188270228	0.00227849	0.075935951	0.16201175	0.0061488	0.020714495	0.00077023	0.009131138	6.73e-05	0.00989549
+3-4:het:>40Mb	0.005373925	0.390284779	1.8e-07	0.00472731	0.002974155	0.00240527	0.00022509	0.02416852	0.002876185	1e-08	6.2e-05	0.00090365	0.00958487	0.16670478	0.00450937	0.00048235	0.000536	0.02652536	0.00256084	0.00119273	2.8e-07	0.00051959	2.1e-07	0.001866582	1.05e-07	0.00309533
+5-8:het:0-100kb	0.000741212	0.001717201	0.00551728	0.068606241	0.003368305	0.00362532	0.01467759	0.032617975	0.001719672	0.00596208	2.95e-05	0.00044794	0.00098094	0.0014848	0.00286475	0.01032126	0.00049621	0.00230818	0.00185133	0.015153	0.00031093	0.00058946	3.53e-05	0.002082402	0.000307891	0.02211369
+5-8:het:100kb-1Mb	0.00011638	0.011630412	0.039523742	0.056865761	0.007209015	0.00454924	0.16196039	0.127337371	0.00135021	0.04005666	0.0438027	0.00783497	0.00090333	0.00011311	0.00878768	0.04438502	0.0124036	0.02222437	0.02780896	0.14454268	0.00022234	0.00175159	0.00091931	0.004128916	0.000567382	0.00622323
+5-8:het:1Mb-10Mb	0.000204002	0.019335548	0.162603387	0.01134511	0.008309545	0.00205142	0.21136197	0.061241481	0.001136105	0.01210908	0.185368842	0.00156351	5.8e-07	3.2e-07	0.00632529	0.08961901	0.129027959	0.14409608	0.02161426	0.10976846	9.72e-06	0.004135055	0.00226165	0.005086422	7.9e-06	2.523e-05
+5-8:het:10Mb-40Mb	1.93e-05	0.025641671	0.122266015	0.00463152	0.00097313	0.00026427	0.0048432	0.008361195	0.000468092	0.00183866	0.057285501	0.00131279	0.00020304	0.00011361	0.0281915	0.08336645	0.055166629	0.18136026	0.00344696	0.01800115	0.00012714	0.001374835	0.00179573	0.002817716	2.11e-08	0.00612999
+5-8:het:>40Mb	0.000525662	0.044174807	0.076936563	1e-08	0.00127684	2.19e-05	0.00032996	0.004528565	0.000413552	0.0	0.01649539	0.00069671	6.82e-05	0.00174446	0.07821007	0.25307107	1e-08	0.09531375	2.3e-07	0.00182344	0.00247148	0.00133954	1.8e-07	0.000780186	9.32e-08	0.00164991
+9+:het:0-100kb	0.000105258	0.000991451	0.00254618	5.16e-05	0.003029025	0.016700899	0.02554054	0.094947456	0.00168183	0.00047103	1e-08	2.48e-05	0.00089424	8.2e-07	0.01505965	0.00338768	5.39e-05	0.0093412	0.00503956	0.0035707	5.99e-05	0.000483875	1.41e-05	0.000621376	0.00193162	7.706999999999999e-05
+9+:het:100kb-1Mb	0.000318177	0.00324101	0.00174383	2.15e-05	0.00738562	0.043428957	0.16018674	0.266746762	0.004252061	0.0002512	8.13e-06	0.00018166	0.00050042	0.00012566	0.00017234	0.0033166	7.49e-05	0.05049958	0.00484797	0.00971177	0.00011614	0.00014049	1.5e-07	0.001350168	0.00202686	3.57e-06
+9+:het:1Mb-10Mb	0.000187035	0.003779865	7.1e-07	2.6e-07	0.00611754	0.00489714	0.14906452	0.110528846	0.000808817	1e-08	0.052794321	0.00016027	0.0027117	9.5e-07	0.00554372	0.00998959	0.00013899	0.08409049	0.01332158	0.00568101	3.6e-07	0.00027061	1.4e-07	0.001385586	0.00173436	2.515e-05
+9+:het:10Mb-40Mb	1.74e-06	0.001908404	0.00197462	2.4e-07	6.79e-05	3.36e-05	0.00053612	0.001809925	3.12e-05	0.00012153	0.00605752	0.00013193	4.29e-05	1.06e-06	0.01155315	0.00316669	0.00012341	0.01848061	1.56e-05	0.00085042	0.00015659	0.000242765	1.4e-07	0.000133182	6.72e-06	0.00012162
+9+:het:>40Mb	1.18e-05	0.00209996	0.00203108	1.47e-05	9.3e-05	2.36e-05	2.25e-05	0.001085855	2.93e-05	0.00030777	0.0003921	3.55e-05	9.77e-05	1.27e-06	0.00768259	0.0067409	1e-08	0.00241512	2.72e-05	3.53e-05	2.31e-05	2.85e-05	1.4e-07	2.28e-05	4.97e-08	4.631e-05