Biomedical evidence, software, infrastructure, and product delivery.

I work across genomics, multi-omics, clinical data, statistical inference, secure computing, and scientific software. My focus is the chain from evidence to usable systems: data structure, method, provenance, documentation, interface, governance, and decision support.

Professional profile: lawless.ch
Major commercial outputs: Switzerland Omics
Main academic outputs: ORCID · Google Scholar
Design and product systems: design.lawless.ch

I build verifiable analytical systems for precision medicine, diagnostics, biomarker research, and biomedical data infrastructure. I am especially interested in converting our basic research into sucessful products for biotech, pharma, and diagnostics. That work depends collaboration, infrastructure, documentation, IP awareness, regulatory judgement, and a clear understanding of how scientific products reach real users.

Core areas:

• Statistical genomics, Bayesian inference, and uncertainty quantification
• Rare disease, infectious disease, host genetics, and precision medicine
• Whole-genome sequencing, RNA-seq, proteomics, metabolomics, and EHR-linked data
• Reproducible R, Python, SQL, Linux, HPC, and cloud workflows
• Scientific software, structured reports, evidence databases, and product-facing systems
• Secure and governance-aware biomedical data infrastructure

My software and product work is grounded in academic and clinical research across genomics, immunology, infectious disease, rare disease, and translational medicine.

Selected awards include the FKZ Children’s Research Centre research prize, Microsoft Azure Research Award, Wellcome Genome Campus visitor research grant, and University of Leeds postgraduate research scholarships.

Output	Scope	Links
QuantBayes Studio	Evidence-based conclusions for AI, science, engineering, and regulated work	site
QuantBayes	Bayesian quantification of genomic evidence sufficiency with posterior intervals	site · article · CRAN · Zenodo
Archipelago	Variant set association statistics and visualisation for complex genomic studies	site · article · CRAN
VCFheader	VCF header parsing and structured standalone HTML reporting	site · browser · CRAN
Evidence ratio	Likelihood-based evidence scale for clinical trials, studies, and analytical results	site · CRAN
PanelAppRex AI	Harmonised disease-gene panels from structured clinical and genetic queries	site · article · repository · dataset
Qualifying variant database	Reusable YAML criteria for reproducible genomic variant interpretation	site · article
Genomic Vault	Long-term custody and controlled access for genomics and precision medicine	platform
IEI genetics database	Genetic panels and prior probabilities for disease-causing variants in inborn errors of immunity	site · article

This account contains research code, R packages, analysis workflows, documentation sites, data products, and product prototypes.

Main repository areas:

• Statistical modelling, machine learning, and reproducible analysis
• Genomics, multi-omics, and biomedical evidence systems
• R and Python packages for scientific computing and reporting
• Secure data workflows, clinical research infrastructure, and structured outputs
• Web products, documentation systems, and scientific interfaces

Languages          R · Python · SQL · Bash · C · Rust · TypeScript
Data               WGS · RNA-seq · proteomics · metabolomics · EHR-linked data
Statistics         Regression · Bayesian inference · machine learning · statistical learning · uncertainty quantification
Systems            Linux · HPC · Docker · Apptainer · Nextflow · Snakemake
Platforms          PostgreSQL · Supabase · Next.js · React · Vercel · APIs
AI                 retrieval · embeddings · structured extraction · agentic workflows
Governance         provenance · auditability · secure data · GDPR/FADP · IVDR-aware workflows