Curate causal graphs for 4 syntrophy/DIET cocultures (000183/188/189/297)#251
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…297) Edison causal-graph runs (PaperQA3), curated conservatively — evidence stays on the parent interaction nodes; InteractionDownstream carries target + causal description only; no new snippets or terms. Record HTML pages regenerated. - 000183 Dehalococcoides-Syntrophomonas TCE dechlorination (PMID:25576615): 2 edges → "Reductive Dechlorination by Dehalococcoides" — H2 from syntrophic butyrate oxidation (demonstrated: nM H2 + strain-195 threshold) and aggregation-shortened interspecies distance (lower-confidence). - 000188 Trichococcus-Syntrophomonas-Methanospirillum butyrate (PMID:35699440): 2 HYPOTHESIZED mediator edges → the ES5-stimulated oxidation/methane node (co-aggregation and proteome response are observed correlates, not proven causal mediators) + a KNOWLEDGE_GAP on the unresolved ES5 bridging/DIET mechanism. - 000189 Syntrophomonas-Methanococcus butyrate (PMID:34603271): 1 edge — syntrophic coupling drives population-ratio convergence + a KNOWLEDGE_GAP (aggregation→enhancement untested; DIET not established for the CNT effect). - 000297 DIETsimp lignocellulose→methane (PMID:42229598): NO edge justified — two parallel proposed/unverified DIET pathways with no causal dependency; recorded as a KNOWLEDGE_GAP. Honors each run's conservative disposition (excluded/unverified elements left out; hypothesized links flagged). ~65/304 records now carry downstream edges. Co-Authored-By: Claude Opus 4.8 (1M context) <noreply@anthropic.com>
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Pull request overview
Curates Edison causal-graph outputs into four existing CommunityMech community records by adding directed downstream causal edges where justified and filing unresolved/unsupported mechanisms as KNOWLEDGE_GAP discussions. This strengthens the causal-graph layer of the curated YAML knowledge base while keeping evidence anchored to the appropriate parent objects and regenerating the corresponding rendered HTML pages.
Changes:
- Added
downstreamcausal edges to specificecological_interactionsin three coculture records (000183/188/189) where the source supports a directed dependency. - Added
KNOWLEDGE_GAPdiscussionsentries to capture unresolved mediation/DIET questions (and explicitly documented “no causal edge justified” for DIETsimp). - Regenerated the affected
docs/communities/*.htmlpages to render downstream effects and discussions.
Reviewed changes
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| File | Description |
|---|---|
| kb/communities/Trichococcus_Syntrophomonas_Methanospirillum_Butyrate_Coculture.yaml | Adds two hypothesized downstream edges to the ES5-stimulation interaction and a knowledge-gap discussion capturing unresolved mediation mechanism. |
| kb/communities/Syntrophomonas_Methanococcus_Butyrate_Growth_Coordination_Coculture.yaml | Adds a downstream edge linking syntrophic coupling to population-ratio convergence and a knowledge-gap discussion for aggregation/DIET uncertainty. |
| kb/communities/DIETsimp_Lignocellulose_to_Methane_DIET_Consortia.yaml | Adds a knowledge-gap discussion documenting why no directed causal edge was justified from the available evidence. |
| kb/communities/Dehalococcoides_Syntrophomonas_TCE_Dechlorination_Coculture.yaml | Adds two downstream edges linking syntrophic butyrate oxidation/aggregation to reductive dechlorination. |
| docs/communities/Trichococcus_Syntrophomonas_Methanospirillum_Butyrate_Coculture.html | Regenerated HTML to render downstream effects and the new discussions section. |
| docs/communities/Syntrophomonas_Methanococcus_Butyrate_Growth_Coordination_Coculture.html | Regenerated HTML to render the new downstream effects and discussions section. |
| docs/communities/DIETsimp_Lignocellulose_to_Methane_DIET_Consortia.html | Regenerated HTML to render the new discussions section. |
| docs/communities/Dehalococcoides_Syntrophomonas_TCE_Dechlorination_Coculture.html | Regenerated HTML to render downstream effects on the relevant interactions. |
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realmarcin
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Add the 4-record batch (000183/188/189/297) to the causal "done so far" list and note that 000297 yielded no justifiable edge (parallel proposed DIET pathways) and that the 6 already-wired matches were left as-is. Co-authored-by: Claude Opus 4.8 (1M context) <noreply@anthropic.com>
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Edison causal-graph runs (PaperQA3 causal-edge mode) for four syntrophy/DIET cocultures that lacked
downstreamedges. Curated conservatively, honoring each run's disposition.InteractionDownstreamcarriestarget+ causaldescriptiononly; evidence stays on parent nodes — no new snippets or terms. Pages regenerated.5 downstream edges + 3 knowledge-gap discussions across 4 records; ~65/304 records now carry causal edges. Excluded/unverified elements (DIET-for-CNT, aggregation→enhancement, neutral-red import) left out per each run's caution.
Continues the causal thread (#226/#229/#230/#243/#246/#249). Provenance bundles under
research/communities/…-causal.*(gitignored). The six already-wired matches (000031–033 DIET, 000068–070 syntrophies) were left as-is.🤖 Generated with Claude Code