diff --git a/hosts/lobtop/programs.nix b/hosts/lobtop/programs.nix
index 032d2f6e..9dceb7de 100644
--- a/hosts/lobtop/programs.nix
+++ b/hosts/lobtop/programs.nix
@@ -19,6 +19,12 @@
     enable = true;
   };
 
+  programs.karabiner = {
+    enable = true;
+    enableDefaults = true;
+    startOnActivation = true;
+  };
+
   programs.fastscripts = {
     enable = true;
     startOnActivation = true;
diff --git a/modules/darwin/programs/default.nix b/modules/darwin/programs/default.nix
index 9e40cdfc..6d65a95b 100644
--- a/modules/darwin/programs/default.nix
+++ b/modules/darwin/programs/default.nix
@@ -6,6 +6,7 @@
     ./daisydisk.nix
     ./fastscripts.nix
     ./iina.nix
+    ./karabiner.nix
     ./little-snitch.nix
     ./popclip.nix
     ./postico.nix
diff --git a/modules/darwin/programs/karabiner.nix b/modules/darwin/programs/karabiner.nix
new file mode 100644
index 00000000..9e36ef2f
--- /dev/null
+++ b/modules/darwin/programs/karabiner.nix
@@ -0,0 +1,118 @@
+{
+  config,
+  lib,
+  pkgs,
+  ...
+}:
+with lib; let
+  cfg = config.programs.karabiner;
+
+  configJson = builtins.toJSON {
+    global.show_in_menu_bar = false;
+    profiles = [
+      {
+        complex_modifications.rules = cfg.complexModifications;
+        inherit (cfg) devices;
+        name = "Default profile";
+        selected = true;
+        virtual_hid_keyboard.keyboard_type_v2 = "ansi";
+      }
+    ];
+  };
+in {
+  options.programs.karabiner = {
+    enable = mkEnableOption "Karabiner-Elements";
+
+    enableDefaults = mkEnableOption "default MX Master 4 M device and mission-control/space-switching complex modifications";
+
+    startOnActivation = mkEnableOption "starting Karabiner-Elements on activation";
+
+    devices = mkOption {
+      type = types.listOf types.attrs;
+      default = [];
+      description = "Device entries to include in the Karabiner profile.";
+    };
+
+    complexModifications = mkOption {
+      type = types.listOf types.attrs;
+      default = [];
+      description = "Complex modification rules to include in the Karabiner profile.";
+    };
+  };
+
+  config = mkMerge [
+    (mkIf cfg.enableDefaults {
+      programs.karabiner.devices = mkDefault [
+        # Logitech MX Master 4 M
+        {
+          identifiers = {
+            is_pointing_device = true;
+            product_id = 45122;
+            vendor_id = 1133;
+          };
+          ignore = false;
+        }
+      ];
+      programs.karabiner.complexModifications = mkDefault [
+        {
+          description = "Mission control";
+          manipulators = [
+            {
+              type = "basic";
+              from.pointing_button = "button7";
+              to = [{key_code = "mission_control";}];
+            }
+          ];
+        }
+        {
+          description = "Thumb button → Right space";
+          manipulators = [
+            {
+              type = "basic";
+              from.pointing_button = "button4";
+              to = [
+                {
+                  key_code = "right_arrow";
+                  modifiers = ["control"];
+                }
+              ];
+            }
+          ];
+        }
+        {
+          description = "Thumb button → Left space";
+          manipulators = [
+            {
+              type = "basic";
+              from.pointing_button = "button5";
+              to = [
+                {
+                  key_code = "left_arrow";
+                  modifiers = ["control"];
+                }
+              ];
+            }
+          ];
+        }
+      ];
+    })
+    (mkIf cfg.enable {
+      environment.systemPackages = [pkgs.karabiner-elements];
+
+      # Karabiner-Elements does not support being managed via defaults(1); write
+      # the JSON config directly during activation instead.
+      system.activationScripts.postActivation.text = let
+        user = lib.escapeShellArg config.system.primaryUser;
+        configFile = pkgs.writeText "karabiner.json" configJson;
+      in ''
+        echo "configuring karabiner-elements..." >&2
+        sudo --user=${user} -- mkdir -p ~${user}/.config/karabiner
+        sudo --user=${user} -- cp -f ${configFile} ~${user}/.config/karabiner/karabiner.json
+      '';
+
+      system.startOnActivation = mkIf cfg.startOnActivation {
+        "karabiner_observer" = "${pkgs.karabiner-elements}/Applications/Karabiner-Elements.app/";
+      };
+    })
+  ];
+}