diff --git a/.changeset/treeview-typeahead-nested-controls.md b/.changeset/treeview-typeahead-nested-controls.md
new file mode 100644
index 00000000000..f10abb09a7d
--- /dev/null
+++ b/.changeset/treeview-typeahead-nested-controls.md
@@ -0,0 +1,5 @@
+---
+'@primer/react': patch
+---
+
+TreeView: Prevent typeahead errors and focus changes when typing in nested controls.
diff --git a/packages/react/src/TreeView/TreeView.test.tsx b/packages/react/src/TreeView/TreeView.test.tsx
index 045e6d6757f..aa9de62940d 100644
--- a/packages/react/src/TreeView/TreeView.test.tsx
+++ b/packages/react/src/TreeView/TreeView.test.tsx
@@ -1,4 +1,5 @@
 import {fireEvent, render, act, screen, waitFor} from '@testing-library/react'
+import userEvent from '@testing-library/user-event'
 import {afterEach, describe, it, expect, vi} from 'vitest'
 import React from 'react'
 import type {SubTreeState} from './TreeView'
@@ -1282,6 +1283,94 @@ describe('Keyboard interactions', () => {
   })
 
   describe('Typeahead', () => {
+    it.each(['z', 'c'])('ignores rapid "%s" key presses from a nested button', key => {
+      vi.useFakeTimers()
+      const onKeyDown = vi.fn()
+      render(
+        <TreeView aria-label="Test tree">
+          <TreeView.Item id="apple" aria-label="Apple">
+            Apple
+            <button type="button" tabIndex={-1} onKeyDown={onKeyDown}>
+              Nested action
+            </button>
+          </TreeView.Item>
+          <TreeView.Item id="banana">Banana</TreeView.Item>
+          <TreeView.Item id="cherry">Cherry</TreeView.Item>
+        </TreeView>,
+      )
+
+      const apple = screen.getByRole('treeitem', {name: 'Apple'})
+      const button = screen.getByRole('button', {name: 'Nested action'})
+      const cherry = screen.getByRole('treeitem', {name: 'Cherry'})
+
+      act(() => apple.focus())
+      act(() => button.focus())
+      expect(button).toHaveFocus()
+
+      expect(fireEvent.keyDown(button, {key})).toBe(true)
+      expect(fireEvent.keyDown(button, {key})).toBe(true)
+      expect(button).toHaveFocus()
+      expect(onKeyDown).toHaveBeenCalledTimes(2)
+
+      act(() => apple.focus())
+      fireEvent.keyDown(apple, {key: 'c'})
+      expect(cherry).toHaveFocus()
+    })
+
+    it('allows typing in a nested input without moving focus', async () => {
+      const user = userEvent.setup()
+      render(
+        <TreeView aria-label="Test tree">
+          <TreeView.Item id="apple" aria-label="Apple">
+            Apple
+            <input aria-label="Filter" />
+          </TreeView.Item>
+          <TreeView.Item id="banana">Banana</TreeView.Item>
+          <TreeView.Item id="cherry">Cherry</TreeView.Item>
+        </TreeView>,
+      )
+
+      const input = screen.getByRole('textbox', {name: 'Filter'})
+
+      await user.type(input, 'ch')
+
+      expect(input).toHaveValue('ch')
+      expect(input).toHaveFocus()
+    })
+
+    it('does not add nested-control keystrokes to an ongoing search', () => {
+      vi.useFakeTimers()
+      render(
+        <TreeView aria-label="Test tree">
+          <TreeView.Item id="apple" aria-label="Apple">
+            Apple
+            <button type="button" tabIndex={-1}>
+              Nested action
+            </button>
+          </TreeView.Item>
+          <TreeView.Item id="cherry">Cherry</TreeView.Item>
+          <TreeView.Item id="cantalope">Cantalope</TreeView.Item>
+        </TreeView>,
+      )
+
+      const apple = screen.getByRole('treeitem', {name: 'Apple'})
+      const button = screen.getByRole('button', {name: 'Nested action'})
+      const cherry = screen.getByRole('treeitem', {name: 'Cherry'})
+      const cantalope = screen.getByRole('treeitem', {name: 'Cantalope'})
+
+      act(() => apple.focus())
+      fireEvent.keyDown(apple, {key: 'c'})
+      expect(cherry).toHaveFocus()
+
+      act(() => button.focus())
+      expect(fireEvent.keyDown(button, {key: 'z'})).toBe(true)
+      expect(button).toHaveFocus()
+
+      act(() => cherry.focus())
+      fireEvent.keyDown(cherry, {key: 'a'})
+      expect(cantalope).toHaveFocus()
+    })
+
     it('moves focus to the next item that matches the typed character', () => {
       render(
         <TreeView aria-label="Test tree">
diff --git a/packages/react/src/TreeView/useTypeahead.ts b/packages/react/src/TreeView/useTypeahead.ts
index 128b6f967eb..dba62025059 100644
--- a/packages/react/src/TreeView/useTypeahead.ts
+++ b/packages/react/src/TreeView/useTypeahead.ts
@@ -63,6 +63,9 @@ export function useTypeahead({containerRef, onFocusChange}: TypeaheadOptions) {
     const container = containerRef.current
 
     function onKeyDown(event: KeyboardEvent) {
+      // Leave keyboard interaction on nested controls to the controls themselves.
+      if (!(event.target instanceof HTMLElement) || event.target.getAttribute('role') !== 'treeitem') return
+
       // Ignore key presses that don't produce a character value
       if (!event.key || event.key.length > 1 || event.key === ' ') return