diff --git a/.changelog/4890.removed b/.changelog/4890.removed
new file mode 100644
index 0000000000..990f8186c8
--- /dev/null
+++ b/.changelog/4890.removed
@@ -0,0 +1 @@
+`opentelemetry-instrumentation-pika`: remove the runtime `packaging` dependency in favor of the internal PEP 440 implementation in `opentelemetry-instrumentation`
diff --git a/instrumentation/opentelemetry-instrumentation-pika/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pika/pyproject.toml
index 65f5b1b983..6fbdc0ba69 100644
--- a/instrumentation/opentelemetry-instrumentation-pika/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-pika/pyproject.toml
@@ -28,7 +28,6 @@ dependencies = [
   "opentelemetry-instrumentation == 0.66b0.dev",
   "opentelemetry-semantic-conventions == 0.66b0.dev",
   "opentelemetry-api ~= 1.5",
-  "packaging >= 20.0",
   "wrapt >= 1.0.0, < 3.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-pika/src/opentelemetry/instrumentation/pika/pika_instrumentor.py b/instrumentation/opentelemetry-instrumentation-pika/src/opentelemetry/instrumentation/pika/pika_instrumentor.py
index 24be559779..9040a75157 100644
--- a/instrumentation/opentelemetry-instrumentation-pika/src/opentelemetry/instrumentation/pika/pika_instrumentor.py
+++ b/instrumentation/opentelemetry-instrumentation-pika/src/opentelemetry/instrumentation/pika/pika_instrumentor.py
@@ -7,7 +7,6 @@
 
 import pika
 import wrapt
-from packaging import version
 from pika.adapters import BlockingConnection
 from pika.adapters.blocking_connection import (
     BlockingChannel,
@@ -17,6 +16,7 @@
 from pika.connection import Connection
 
 from opentelemetry import trace
+from opentelemetry.instrumentation._packaging import version
 from opentelemetry.instrumentation.instrumentor import BaseInstrumentor
 from opentelemetry.instrumentation.pika import utils
 from opentelemetry.instrumentation.pika.package import _instruments