diff --git a/.changelog/4889.removed b/.changelog/4889.removed
new file mode 100644
index 0000000000..595142f917
--- /dev/null
+++ b/.changelog/4889.removed
@@ -0,0 +1 @@
+`opentelemetry-instrumentation-flask`: remove the runtime `packaging` dependency in favor of the internal PEP 440 implementation in `opentelemetry-instrumentation`
diff --git a/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml b/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
index f38e8144e1..835f7366e6 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
@@ -30,7 +30,6 @@ dependencies = [
   "opentelemetry-instrumentation-wsgi == 0.66b0.dev",
   "opentelemetry-semantic-conventions == 0.66b0.dev",
   "opentelemetry-util-http == 0.66b0.dev",
-  "packaging >= 21.0",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
index 9819c16022..71e035895b 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
@@ -250,10 +250,12 @@ def response_hook(span: Span, status: str, response_headers: List):
 from typing import Collection
 
 import flask
-from packaging import version as package_version
 
 import opentelemetry.instrumentation.wsgi as otel_wsgi
 from opentelemetry import context, trace
+from opentelemetry.instrumentation._packaging import (
+    version as package_version,
+)
 from opentelemetry.instrumentation._semconv import (
     HTTP_DURATION_HISTOGRAM_BUCKETS_NEW,
     _get_schema_url,