diff --git a/.changeset/uri-template-multi-variable-encoding.md b/.changeset/uri-template-multi-variable-encoding.md
new file mode 100644
index 0000000000..034daa3872
--- /dev/null
+++ b/.changeset/uri-template-multi-variable-encoding.md
@@ -0,0 +1,7 @@
+---
+'@modelcontextprotocol/core-internal': patch
+'@modelcontextprotocol/client': patch
+'@modelcontextprotocol/server': patch
+---
+
+`UriTemplate.expand()` now percent-encodes the values of multi-variable expressions. A template with two or more variables in one expression (`{x,y}`) interpolated its values raw, so a value carrying a space or a reserved character produced a malformed URI — `new UriTemplate('{x,y}').expand({ x: 'value with spaces', y: 'a/b?c&d' })` returned `value with spaces,a/b?c&d` instead of `value%20with%20spaces,a%2Fb%3Fc%26d`. Single-variable expressions already encoded correctly, so the defect only showed once a second variable was added to the same expression. Encoding is operator-aware, matching the single-variable path: `{+x,y}` and `{#x,y}` keep reserved characters and encode the rest.
diff --git a/packages/core-internal/src/shared/uriTemplate.ts b/packages/core-internal/src/shared/uriTemplate.ts
index 5ffe213acd..2be6363bd2 100644
--- a/packages/core-internal/src/shared/uriTemplate.ts
+++ b/packages/core-internal/src/shared/uriTemplate.ts
@@ -138,7 +138,7 @@ export class UriTemplate {
         if (part.names.length > 1) {
             const values = part.names.map(name => variables[name]).filter(v => v !== undefined);
             if (values.length === 0) return '';
-            return values.map(v => (Array.isArray(v) ? v[0] : v)).join(',');
+            return values.map(v => this.encodeValue(Array.isArray(v) ? (v[0] ?? '') : v, part.operator)).join(',');
         }
 
         const value = variables[part.name];
diff --git a/packages/core-internal/test/shared/uriTemplate.test.ts b/packages/core-internal/test/shared/uriTemplate.test.ts
index bfc3237872..0f7364eba7 100644
--- a/packages/core-internal/test/shared/uriTemplate.test.ts
+++ b/packages/core-internal/test/shared/uriTemplate.test.ts
@@ -35,6 +35,11 @@ describe('UriTemplate', () => {
             const template = new UriTemplate('{var}');
             expect(template.expand({ var: 'value with spaces' })).toBe('value%20with%20spaces');
         });
+
+        it('should encode reserved characters in multiple variables', () => {
+            const template = new UriTemplate('{x,y}');
+            expect(template.expand({ x: 'value with spaces', y: 'a/b?c&d' })).toBe('value%20with%20spaces,a%2Fb%3Fc%26d');
+        });
     });
 
     describe('reserved expansion', () => {
@@ -43,6 +48,11 @@ describe('UriTemplate', () => {
             expect(template.expand({ path: '/foo/bar' })).toBe('/foo/bar/here');
             expect(template.variableNames).toEqual(['path']);
         });
+
+        it('should keep reserved characters but encode spaces for multiple variables with + operator', () => {
+            const template = new UriTemplate('{+path,name}');
+            expect(template.expand({ path: '/foo/bar', name: 'a b' })).toBe('/foo/bar,a%20b');
+        });
     });
 
     describe('fragment expansion', () => {