diff --git a/driver.go b/driver.go
index 8d102f36..a3fc5dad 100644
--- a/driver.go
+++ b/driver.go
@@ -1158,6 +1158,9 @@ func runTransactionWithOptions(ctx context.Context, db *sql.DB, opts *sql.TxOpti
 		if err == nil {
 			err = tx.Commit()
 			if err == nil {
+				if !isSpannerConn || (opts != nil && opts.ReadOnly) {
+					return nil, nil
+				}
 				resp, err := getCommitResponse(conn)
 				if err != nil {
 					return nil, err
diff --git a/driver_non_spanner_test.go b/driver_non_spanner_test.go
new file mode 100644
index 00000000..6cffe3fe
--- /dev/null
+++ b/driver_non_spanner_test.go
@@ -0,0 +1,70 @@
+// Copyright 2026 Google LLC
+//
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+//     https://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS,
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+
+package spannerdriver
+
+import (
+	"context"
+	"database/sql"
+	"database/sql/driver"
+	"testing"
+
+	"cloud.google.com/go/spanner"
+)
+
+func init() {
+	sql.Register("fake", &fakeDriver{})
+}
+
+type fakeDriver struct{}
+
+func (d *fakeDriver) Open(name string) (driver.Conn, error) { return &fakeDriverConn{}, nil }
+
+type fakeDriverConn struct{}
+
+func (c *fakeDriverConn) Prepare(query string) (driver.Stmt, error) { return &fakeStmt{}, nil }
+func (c *fakeDriverConn) Close() error                              { return nil }
+func (c *fakeDriverConn) Begin() (driver.Tx, error)                 { return &fakeTx{}, nil }
+
+type fakeStmt struct{}
+
+func (s *fakeStmt) Close() error                                    { return nil }
+func (s *fakeStmt) NumInput() int                                   { return 0 }
+func (s *fakeStmt) Exec(args []driver.Value) (driver.Result, error) { return nil, nil }
+func (s *fakeStmt) Query(args []driver.Value) (driver.Rows, error)  { return nil, nil }
+
+type fakeTx struct{}
+
+func (t *fakeTx) Commit() error   { return nil }
+func (t *fakeTx) Rollback() error { return nil }
+
+func TestRunTransaction_NonSpannerConnection(t *testing.T) {
+	db, err := sql.Open("fake", "any-dsn")
+	if err != nil {
+		t.Fatal(err)
+	}
+	defer db.Close()
+
+	ctx := context.Background()
+	// RunTransaction should succeed and return nil, nil commit response for non-Spanner connections
+	resp, err := RunTransactionWithCommitResponse(ctx, db, nil, func(ctx context.Context, tx *sql.Tx) error {
+		return nil
+	}, spanner.TransactionOptions{})
+	if err != nil {
+		t.Fatalf("RunTransactionWithCommitResponse failed: %v", err)
+	}
+	if resp != nil {
+		t.Errorf("expected nil commit response, got: %v", resp)
+	}
+}
diff --git a/driver_with_mockserver_test.go b/driver_with_mockserver_test.go
index 6d90afa6..b4f466d6 100644
--- a/driver_with_mockserver_test.go
+++ b/driver_with_mockserver_test.go
@@ -4765,6 +4765,51 @@ func TestRunTransaction(t *testing.T) {
 	}
 }
 
+func TestRunTransactionReadOnly(t *testing.T) {
+	t.Parallel()
+
+	ctx := context.Background()
+	db, server, teardown := setupTestDBConnection(t)
+	defer teardown()
+
+	err := RunTransaction(ctx, db, &sql.TxOptions{ReadOnly: true}, func(ctx context.Context, tx *sql.Tx) error {
+		rows, err := tx.Query(testutil.SelectFooFromBar)
+		if err != nil {
+			return err
+		}
+		defer silentClose(rows)
+		for want := int64(1); rows.Next(); want++ {
+			var got int64
+			if err := rows.Scan(&got); err != nil {
+				return err
+			}
+			if got != want {
+				return fmt.Errorf("value mismatch\nGot: %v\nWant: %v", got, want)
+			}
+		}
+		return rows.Err()
+	})
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	requests := server.TestSpanner.DrainRequestsFromServer()
+	sqlRequests := testutil.RequestsOfType(requests, reflect.TypeOf(&sppb.ExecuteSqlRequest{}))
+	if g, w := len(sqlRequests), 1; g != w {
+		t.Fatalf("ExecuteSqlRequests count mismatch\nGot: %v\nWant: %v", g, w)
+	}
+	req := sqlRequests[0].(*sppb.ExecuteSqlRequest)
+	if req.Transaction == nil {
+		t.Fatalf("missing transaction for ExecuteSqlRequest")
+	}
+
+	// Verify that NO commit request was sent
+	commitRequests := testutil.RequestsOfType(requests, reflect.TypeOf(&sppb.CommitRequest{}))
+	if g, w := len(commitRequests), 0; g != w {
+		t.Fatalf("commit requests count mismatch\nGot: %v\nWant: %v", g, w)
+	}
+}
+
 func TestRunTransactionCommitAborted(t *testing.T) {
 	t.Parallel()