diff --git a/src/clusterfuzz/_internal/system/process_handler.py b/src/clusterfuzz/_internal/system/process_handler.py
index 27f697e6fbd..e2b62e05c70 100644
--- a/src/clusterfuzz/_internal/system/process_handler.py
+++ b/src/clusterfuzz/_internal/system/process_handler.py
@@ -174,6 +174,7 @@ def run_process(cmdline,
   if is_android:
     # Clear the log upfront.
     android.logger.clear_log()
+    initial_uptime = android.adb.time_since_last_reboot()
 
     # Run the app.
     adb_output = android.adb.run_command(
@@ -253,15 +254,26 @@ def run_process(cmdline,
     # waits for device to be online.
     time.sleep(ANDROID_CRASH_LOGCAT_WAIT_TIME)
     output = android.logger.log_output()
+    app_package = android.app.get_package_name()
+    process_pid = android.util.get_latest_pid_for_package(app_package)
+    exit_info = android.util.get_exit_info_for_pid(app_package, process_pid)
 
-    if android.constants.LOW_MEMORY_REGEX.search(output):
+    if android.util.activity_crashed(exit_info):
+      logs.warning(f'Activity Crashed with: {exit_info}')
+      return_code = exit_info.reason
+
+    elif android.constants.LOW_MEMORY_REGEX.search(output):
       # If the device is low on memory, we should force reboot and bail out to
       # prevent device from getting in a frozen state.
       logs.info('Device is low on memory, rebooting.', output=output)
       android.adb.hard_reset()
       android.adb.wait_for_device()
 
-    elif android.adb.time_since_last_reboot() < time.time() - start_time:
+    elif android.adb.time_since_last_reboot() < initial_uptime:
+      logs.info(
+          'Device rebooted mid-run',
+          output=f'initial uptime: {initial_uptime}, '
+          f'current uptime: {android.adb.time_since_last_reboot()}')
       # Check if a reboot has happened, if yes, append log output before reboot
       # and kernel logs content to output.
       log_before_last_reboot = android.logger.log_output_before_last_reboot()
diff --git a/src/clusterfuzz/_internal/tests/core/system/process_handler_test.py b/src/clusterfuzz/_internal/tests/core/system/process_handler_test.py
index a4712cb75ca..7feb8bf9a1d 100644
--- a/src/clusterfuzz/_internal/tests/core/system/process_handler_test.py
+++ b/src/clusterfuzz/_internal/tests/core/system/process_handler_test.py
@@ -16,6 +16,8 @@
 import unittest
 from unittest import mock
 
+from clusterfuzz._internal.platforms.android import constants
+from clusterfuzz._internal.platforms.android import util
 from clusterfuzz._internal.system import process_handler
 from clusterfuzz._internal.tests.test_libs import helpers as test_helpers
 
@@ -149,3 +151,58 @@ def test_process_1_no_terminate_with_wrong_case(self):
   def test_process_1_no_kill_with_wrong_case(self):
     process_handler.terminate_processes_matching_cmd_line('/a/b/C', kill=True)
     self.assertEqual(0, self.mock.terminate_process.call_count)
+
+
+class RunProcessAndroidTest(unittest.TestCase):
+  """Tests run_process on Android platform."""
+
+  def setUp(self):
+    test_helpers.patch_environ(self)
+    test_helpers.patch(self, [
+        'clusterfuzz._internal.system.environment.platform',
+        'clusterfuzz._internal.platforms.android.logger.clear_log',
+        'clusterfuzz._internal.platforms.android.logger.log_output',
+        'clusterfuzz._internal.platforms.android.adb.time_since_last_reboot',
+        'clusterfuzz._internal.platforms.android.adb.run_command',
+        'clusterfuzz._internal.platforms.android.adb.get_ps_output',
+        'clusterfuzz._internal.platforms.android.app.get_package_name',
+        'clusterfuzz._internal.platforms.android.app.stop',
+        'clusterfuzz._internal.platforms.android.util.get_latest_pid_for_package',
+        'clusterfuzz._internal.platforms.android.util.get_exit_info_for_pid',
+        'clusterfuzz._internal.platforms.android.util.activity_crashed',
+        'time.sleep',
+    ])
+
+    self.mock.platform.return_value = 'ANDROID'
+    self.mock.get_package_name.return_value = 'com.example.app'
+    self.mock.time_since_last_reboot.return_value = 100.0
+    self.mock.log_output.return_value = ''
+    self.mock.run_command.return_value = ''
+    self.mock.get_ps_output.return_value = ''
+
+  def test_run_process_android_activity_crashed(self):
+    """Checks that run_process sets return_code from exit_info.reason and logs warning when an Android activity crash is detected."""
+    exit_info = util.ProcessExitInfo(
+        reason=constants.ExitReason.CRASH_NATIVE,
+        reason_name='APP CRASH(NATIVE)',
+        subreason=0,
+        subreason_name='',
+        status=constants.ExitStatus.SIGSEGV)
+    self.mock.get_latest_pid_for_package.return_value = 1234
+    self.mock.get_exit_info_for_pid.return_value = exit_info
+    self.mock.activity_crashed.return_value = True
+
+    return_code, _, _ = process_handler.run_process(
+        'am start -n com.example.app/.MainActivity')
+    self.mock.activity_crashed.assert_called_once_with(exit_info)
+    self.assertEqual(return_code, 5)
+
+  def test_run_process_android_no_crash(self):
+    """Checks that run_process returns 0 return_code when Android activity has not crashed."""
+    self.mock.get_latest_pid_for_package.return_value = 1234
+    self.mock.get_exit_info_for_pid.return_value = None
+    self.mock.activity_crashed.return_value = False
+
+    return_code, _, _ = process_handler.run_process(
+        'am start -n com.example.app/.MainActivity')
+    self.assertEqual(return_code, 0)