diff --git a/packages/cloudflare/src/vite/flueRuntime.ts b/packages/cloudflare/src/vite/flueRuntime.ts
new file mode 100644
index 000000000000..b69c9000fac0
--- /dev/null
+++ b/packages/cloudflare/src/vite/flueRuntime.ts
@@ -0,0 +1,71 @@
+import { createRequire } from 'node:module';
+import { resolve } from 'node:path';
+import MagicString from 'magic-string';
+
+// Namespace binding the injected provider import uses; read back by the integration
+// off the global marker.
+const PROVIDER_IDENTIFIER = '__SENTRY_FLUE_RUNTIME__';
+
+const FLUE_MODULE = '@flue/runtime';
+
+// The bundled `@sentry/server-utils` Flue integration module (ESM build — the only one a
+// worker loads). It reads `@flue/runtime` off the global marker this provider populates,
+// because `instrument()` registers into module-scope state no channel payload can carry.
+const FLUE_INTEGRATION_ID = /@sentry\/server-utils\/build\/esm\/integrations\/flue\.js$/;
+
+/** Whether `id` is the Sentry Flue integration module the provider injects into. */
+export function isFlueIntegrationModuleId(id: string): boolean {
+  const normalizedId = id.replace(/\\/g, '/').replace(/[?#].*$/, '');
+  return FLUE_INTEGRATION_ID.test(normalizedId);
+}
+
+/**
+ * Splices a static `import * as … from '@flue/runtime'` into Sentry's own Flue integration module
+ * and exposes the namespace on the global orchestrion marker.
+ *
+ * Flue is registered rather than patched — `instrument()` writes into module-scope state — so
+ * instrumenting it needs that module's own binding, and no channel payload carries one. On Node the
+ * user passes it by calling `instrument()` themselves; a bundled worker has no `node_modules` to
+ * resolve from, so it is supplied at build time instead.
+ */
+export function sentryFlueRuntimeProviderPlugin(): {
+  name: string;
+  configResolved(config: { root: string }): void;
+  transform(code: string, id: string): { code: string; map: ReturnType<MagicString['generateMap']> } | undefined;
+} {
+  let providerSnippet: string | undefined;
+
+  return {
+    name: 'sentry-cloudflare-flue-runtime-provider',
+
+    configResolved(config: { root: string }): void {
+      // Build-time only; never ships to the worker. `@flue/runtime` is ESM-only, so an installed
+      // copy throws `ERR_PACKAGE_PATH_NOT_EXPORTED` and only a missing one throws `MODULE_NOT_FOUND`.
+      // Not `import.meta.resolve`: `parentURL` is ignored without a flag, and it is absent from the
+      // CJS build.
+      try {
+        createRequire(resolve(config.root, 'noop.js')).resolve(FLUE_MODULE);
+      } catch (error) {
+        if ((error as NodeJS.ErrnoException | undefined)?.code !== 'ERR_PACKAGE_PATH_NOT_EXPORTED') {
+          return;
+        }
+      }
+      // A getter where Mastra assigns: the bundler may evaluate Sentry's module before
+      // `@flue/runtime` is initialized, and assigning there would store `undefined`.
+      providerSnippet =
+        `import * as ${PROVIDER_IDENTIFIER} from '${FLUE_MODULE}';\n` +
+        '(globalThis.__SENTRY_ORCHESTRION__ = globalThis.__SENTRY_ORCHESTRION__ || {});\n' +
+        '(globalThis.__SENTRY_ORCHESTRION__.providedModules = globalThis.__SENTRY_ORCHESTRION__.providedModules || {});\n' +
+        `Object.defineProperty(globalThis.__SENTRY_ORCHESTRION__.providedModules, '${FLUE_MODULE}', ` +
+        `{ configurable: true, get() { return ${PROVIDER_IDENTIFIER}; } });\n`;
+    },
+
+    transform(code: string, id: string): { code: string; map: ReturnType<MagicString['generateMap']> } | undefined {
+      if (!providerSnippet || !isFlueIntegrationModuleId(id)) return undefined;
+
+      const ms = new MagicString(code);
+      ms.prepend(providerSnippet);
+      return { code: ms.toString(), map: ms.generateMap({ hires: true }) };
+    },
+  };
+}
diff --git a/packages/cloudflare/src/vite/index.ts b/packages/cloudflare/src/vite/index.ts
index be679c4823f5..d6005250d9ee 100644
--- a/packages/cloudflare/src/vite/index.ts
+++ b/packages/cloudflare/src/vite/index.ts
@@ -5,6 +5,7 @@
 // expose it — same setup as `@sentry/server-utils/orchestrion/vite` itself.
 import { sentryOrchestrionPlugin } from '@sentry/server-utils/orchestrion/vite';
 import { sentryCloudflareAutoInstrumentPlugin } from './autoInstrument';
+import { sentryFlueRuntimeProviderPlugin } from './flueRuntime';
 import { sentryMastraObservabilityProviderPlugin } from './mastraObservability';
 
 /**
@@ -91,6 +92,7 @@ export function sentryCloudflareVitePlugin(options: SentryCloudflareVitePluginOp
       dcModule: '@sentry/cloudflare/orchestrion-diagnostics-channel',
     }),
     sentryMastraObservabilityProviderPlugin(),
+    sentryFlueRuntimeProviderPlugin(),
     ...(options.autoInstrumentation !== false
       ? [sentryCloudflareAutoInstrumentPlugin({ wranglerConfigPath: options.wranglerConfigPath })]
       : []),
diff --git a/packages/cloudflare/test/vite/flueRuntime.test.ts b/packages/cloudflare/test/vite/flueRuntime.test.ts
new file mode 100644
index 000000000000..7d617fd030d7
--- /dev/null
+++ b/packages/cloudflare/test/vite/flueRuntime.test.ts
@@ -0,0 +1,133 @@
+import { mkdirSync, mkdtempSync, writeFileSync } from 'node:fs';
+import { tmpdir } from 'node:os';
+import { join } from 'node:path';
+import { beforeAll, describe, expect, it } from 'vitest';
+import { sentryCloudflareVitePlugin } from '../../src/vite/index';
+import { isFlueIntegrationModuleId, sentryFlueRuntimeProviderPlugin } from '../../src/vite/flueRuntime';
+
+const PROVIDER_PLUGIN = 'sentry-cloudflare-flue-runtime-provider';
+const FLUE_INTEGRATION_MODULE = '/app/node_modules/@sentry/server-utils/build/esm/integrations/flue.js';
+
+/** An app root whose `node_modules` holds an ESM-only `@flue/runtime`, as published. */
+function createRootWithFlue(): string {
+  const root = mkdtempSync(join(tmpdir(), 'sentry-flue-root-'));
+  const pkgDir = join(root, 'node_modules', '@flue', 'runtime');
+  mkdirSync(join(pkgDir, 'dist'), { recursive: true });
+  writeFileSync(
+    join(pkgDir, 'package.json'),
+    // No `require` condition — the reason `resolve()` reports ERR_PACKAGE_PATH_NOT_EXPORTED.
+    JSON.stringify({
+      name: '@flue/runtime',
+      version: '2.0.8',
+      type: 'module',
+      exports: { '.': { import: './dist/index.mjs' } },
+    }),
+  );
+  writeFileSync(join(pkgDir, 'dist', 'index.mjs'), 'export const instrument = () => {};\n');
+  return root;
+}
+
+function createEmptyRoot(): string {
+  return mkdtempSync(join(tmpdir(), 'sentry-flue-empty-'));
+}
+
+describe('isFlueIntegrationModuleId', () => {
+  it('matches the ESM Flue integration module', () => {
+    expect(isFlueIntegrationModuleId(FLUE_INTEGRATION_MODULE)).toBe(true);
+  });
+
+  it('ignores a trailing query/hash Vite may append', () => {
+    expect(isFlueIntegrationModuleId(`${FLUE_INTEGRATION_MODULE}?v=abc`)).toBe(true);
+  });
+
+  it('normalizes Windows separators', () => {
+    expect(
+      isFlueIntegrationModuleId('C:\\app\\node_modules\\@sentry\\server-utils\\build\\esm\\integrations\\flue.js'),
+    ).toBe(true);
+  });
+
+  it('does not match the CJS build (workers load ESM)', () => {
+    expect(isFlueIntegrationModuleId('/app/node_modules/@sentry/server-utils/build/cjs/integrations/flue.js')).toBe(
+      false,
+    );
+  });
+
+  it('does not match another integration module', () => {
+    expect(isFlueIntegrationModuleId('/app/node_modules/@sentry/server-utils/build/esm/integrations/mastra.js')).toBe(
+      false,
+    );
+  });
+
+  it('does not match Flue itself', () => {
+    expect(isFlueIntegrationModuleId('/app/node_modules/@flue/runtime/dist/index.mjs')).toBe(false);
+  });
+});
+
+describe('sentryFlueRuntimeProviderPlugin', () => {
+  describe('when the app has @flue/runtime installed', () => {
+    let root: string;
+
+    beforeAll(() => {
+      root = createRootWithFlue();
+    });
+
+    it('injects the provider even though the package is ESM-only', () => {
+      // Regression guard: treating that error as "absent" silently disabled auto-instrumentation.
+      const plugin = sentryFlueRuntimeProviderPlugin();
+      plugin.configResolved({ root });
+
+      const result = plugin.transform('export const x = 1;', FLUE_INTEGRATION_MODULE);
+
+      expect(result?.code).toContain("import * as __SENTRY_FLUE_RUNTIME__ from '@flue/runtime';");
+      expect(result?.code).toContain('__SENTRY_ORCHESTRION__.providedModules');
+      expect(result?.code).toContain('export const x = 1;');
+    });
+
+    it('exposes the namespace through a getter rather than a snapshot', () => {
+      const plugin = sentryFlueRuntimeProviderPlugin();
+      plugin.configResolved({ root });
+
+      expect(plugin.transform('', FLUE_INTEGRATION_MODULE)?.code).toContain(
+        'get() { return __SENTRY_FLUE_RUNTIME__; }',
+      );
+    });
+
+    it('leaves every other module untouched', () => {
+      const plugin = sentryFlueRuntimeProviderPlugin();
+      plugin.configResolved({ root });
+
+      expect(plugin.transform('export const x = 1;', '/app/src/index.ts')).toBeUndefined();
+    });
+  });
+
+  describe('when the app does not have @flue/runtime installed', () => {
+    it('injects nothing', () => {
+      const plugin = sentryFlueRuntimeProviderPlugin();
+      plugin.configResolved({ root: createEmptyRoot() });
+
+      expect(plugin.transform('export const x = 1;', FLUE_INTEGRATION_MODULE)).toBeUndefined();
+    });
+
+    it("resolves from the app root, not from Sentry's own install", () => {
+      // This repo has no `@flue/runtime`, so only an app root that does can pass the check.
+      const withFlue = sentryFlueRuntimeProviderPlugin();
+      withFlue.configResolved({ root: createRootWithFlue() });
+
+      const withoutFlue = sentryFlueRuntimeProviderPlugin();
+      withoutFlue.configResolved({ root: createEmptyRoot() });
+
+      expect(withFlue.transform('', FLUE_INTEGRATION_MODULE)).toBeDefined();
+      expect(withoutFlue.transform('', FLUE_INTEGRATION_MODULE)).toBeUndefined();
+    });
+  });
+});
+
+describe('sentryCloudflareVitePlugin', () => {
+  it('always includes the Flue runtime provider plugin', () => {
+    expect(sentryCloudflareVitePlugin().map(plugin => plugin.name)).toContain(PROVIDER_PLUGIN);
+    // Not gated by auto-instrumentation: it injects into Sentry's own module, not the entry.
+    expect(sentryCloudflareVitePlugin({ autoInstrumentation: false }).map(plugin => plugin.name)).toContain(
+      PROVIDER_PLUGIN,
+    );
+  });
+});
diff --git a/packages/server-utils/src/ai/flue/constants.ts b/packages/server-utils/src/ai/flue/constants.ts
index ae568d24312a..6a3bbaaefaa9 100644
--- a/packages/server-utils/src/ai/flue/constants.ts
+++ b/packages/server-utils/src/ai/flue/constants.ts
@@ -1,3 +1,7 @@
+export const FLUE_INTEGRATION_NAME = 'Flue' as const;
+
+export const FLUE_MODULE_NAME = '@flue/runtime';
+
 export const FLUE_ORIGIN = 'auto.ai.flue';
 
 /**
diff --git a/packages/server-utils/src/index.ts b/packages/server-utils/src/index.ts
index 57fa3f913cda..c49e6220835f 100644
--- a/packages/server-utils/src/index.ts
+++ b/packages/server-utils/src/index.ts
@@ -43,6 +43,7 @@ export { knexIntegration } from './integrations/knex';
 export { langChainIntegration } from './integrations/langchain';
 export { langGraphIntegration } from './integrations/langgraph';
 export { createFlueInstrumentation } from './ai/flue';
+export { flueIntegration } from './integrations/flue';
 export type { FlueOptions } from './ai/flue';
 export { mastraIntegration } from './integrations/mastra';
 export { SentryMastraExporter } from './ai/mastra';
diff --git a/packages/server-utils/src/integrations/flue.ts b/packages/server-utils/src/integrations/flue.ts
new file mode 100644
index 000000000000..915c237aabe3
--- /dev/null
+++ b/packages/server-utils/src/integrations/flue.ts
@@ -0,0 +1,47 @@
+import type { IntegrationFn } from '@sentry/core';
+import { debug, defineIntegration, GLOBAL_OBJ } from '@sentry/core';
+import type { FlueOptions } from '../ai/flue';
+import { createFlueInstrumentation } from '../ai/flue';
+import { FLUE_INTEGRATION_NAME, FLUE_MODULE_NAME } from '../ai/flue/constants';
+import { DEBUG_BUILD } from '../debug-build';
+
+type FlueInstrumentFn = (instrumentation: ReturnType<typeof createFlueInstrumentation>) => unknown;
+
+/**
+ * Register the instrumentation with Flue on the user's behalf, when the runtime binding is available.
+ *
+ * Flue is registered rather than patched — `instrument()` writes into module-scope state — so this
+ * needs a reference to that module's own binding. In a bundled worker there is no `node_modules` to
+ * resolve one from, so `@sentry/cloudflare/vite` splices a static `@flue/runtime` import into this
+ * module at build time and stashes the namespace on the global marker. Outside that setup the marker
+ * is empty and this no-ops, leaving the user's own `instrument(Sentry.createFlueInstrumentation())`
+ * as the way in.
+ */
+const _flueIntegration = ((options: FlueOptions = {}) => {
+  return {
+    name: FLUE_INTEGRATION_NAME,
+    setup() {
+      const provided = GLOBAL_OBJ.__SENTRY_ORCHESTRION__?.providedModules?.[FLUE_MODULE_NAME];
+      const instrument = provided?.instrument as FlueInstrumentFn | undefined;
+
+      if (typeof instrument !== 'function') {
+        DEBUG_BUILD && debug.log('[Flue] no provided `@flue/runtime` binding; skipping auto-registration');
+        return;
+      }
+
+      try {
+        instrument(createFlueInstrumentation(options));
+      } catch (error) {
+        // Never rethrow: `setup()` runs inside `Sentry.init()`, which core calls unguarded and
+        // Cloudflare calls per request, so throwing here would take down the request handler.
+        if ((error as Error | undefined)?.name === 'InstrumentationAlreadyInstalledError') {
+          DEBUG_BUILD && debug.log('[Flue] already instrumented by the app; skipping auto-registration');
+        } else {
+          debug.warn('[Flue] auto-registration failed; Flue spans will not be recorded:', error);
+        }
+      }
+    },
+  };
+}) satisfies IntegrationFn;
+
+export const flueIntegration = defineIntegration(_flueIntegration);
diff --git a/packages/server-utils/src/orchestrion/config/channel-integration-definitions.ts b/packages/server-utils/src/orchestrion/config/channel-integration-definitions.ts
index 73d7c164cfe7..3935735ac3b9 100644
--- a/packages/server-utils/src/orchestrion/config/channel-integration-definitions.ts
+++ b/packages/server-utils/src/orchestrion/config/channel-integration-definitions.ts
@@ -43,6 +43,7 @@ export const CHANNEL_INTEGRATION_DEFINITIONS = [
   },
   { exportName: 'langGraphIntegration', modules: ['@langchain/langgraph'] },
   { exportName: 'mastraIntegration', modules: ['@mastra/core'] },
+  { exportName: 'flueIntegration', modules: ['@flue/runtime'] },
   { exportName: 'awsIntegration', modules: ['@aws-sdk/smithy-client', '@smithy/core', '@smithy/smithy-client'] },
   { exportName: 'firebaseIntegration', modules: ['@firebase/firestore', 'firebase-functions'] },
   { exportName: 'amqplibIntegration', modules: ['amqplib'] },
diff --git a/packages/server-utils/src/orchestrion/config/flue.ts b/packages/server-utils/src/orchestrion/config/flue.ts
new file mode 100644
index 000000000000..da6841a1ae9b
--- /dev/null
+++ b/packages/server-utils/src/orchestrion/config/flue.ts
@@ -0,0 +1,12 @@
+import type { InstrumentationConfig } from '../apmTypes';
+import { registrationOnly } from './registration-only';
+
+/**
+ * Flue publishes no diagnostics channels and needs none: it is instrumented by registering with
+ * `instrument()`, not by patching call sites. Transforming the entry is only how the module's
+ * integration gets registered at evaluation time, which is what installs it on a bundler-only SDK
+ * like `@sentry/cloudflare`.
+ */
+export const flueConfig = [
+  registrationOnly({ name: '@flue/runtime', versionRange: '>=2.0.0 <3.0.0', filePath: 'dist/index.mjs' }),
+] satisfies InstrumentationConfig[];
diff --git a/packages/server-utils/src/orchestrion/config/index.ts b/packages/server-utils/src/orchestrion/config/index.ts
index 723c5857b8f1..fe9745acb79e 100644
--- a/packages/server-utils/src/orchestrion/config/index.ts
+++ b/packages/server-utils/src/orchestrion/config/index.ts
@@ -19,6 +19,7 @@ import { koaConfig } from './koa';
 import { langchainConfig } from './langchain';
 import { langgraphConfig } from './langgraph';
 import { lruMemoizerConfig } from './lru-memoizer';
+import { flueConfig } from './flue';
 import { mastraConfig } from './mastra';
 import { mistralConfig } from './mistral';
 import { mongodbConfig } from './mongodb';
@@ -67,6 +68,7 @@ export const SENTRY_INSTRUMENTATIONS: InstrumentationConfig[] = [
   ...langchainConfig,
   ...langgraphConfig,
   ...lruMemoizerConfig,
+  ...flueConfig,
   ...mastraConfig,
   ...mistralConfig,
   ...mongodbConfig,
diff --git a/packages/server-utils/test/integrations/flue.test.ts b/packages/server-utils/test/integrations/flue.test.ts
new file mode 100644
index 000000000000..48379fc1c9c0
--- /dev/null
+++ b/packages/server-utils/test/integrations/flue.test.ts
@@ -0,0 +1,68 @@
+import { debug, GLOBAL_OBJ } from '@sentry/core';
+import { afterEach, describe, expect, it, vi } from 'vitest';
+import { flueIntegration } from '../../src/integrations/flue';
+
+function setProvidedFlue(instrument: unknown): void {
+  const marker = (GLOBAL_OBJ.__SENTRY_ORCHESTRION__ ??= {} as NonNullable<typeof GLOBAL_OBJ.__SENTRY_ORCHESTRION__>);
+  (marker as { providedModules?: Record<string, unknown> }).providedModules = {
+    '@flue/runtime': { instrument },
+  };
+}
+
+function clearMarker(): void {
+  delete (GLOBAL_OBJ as { __SENTRY_ORCHESTRION__?: unknown }).__SENTRY_ORCHESTRION__;
+}
+
+/** Flue's own error for a duplicate `instrument()`, which sets `name` on the instance. */
+function alreadyInstalledError(): Error {
+  const error = new Error('An instrumentation is already installed for this key');
+  error.name = 'InstrumentationAlreadyInstalledError';
+  return error;
+}
+
+describe('flueIntegration', () => {
+  afterEach(() => {
+    clearMarker();
+    vi.restoreAllMocks();
+  });
+
+  it('registers the instrumentation when a Flue binding is provided', () => {
+    const instrument = vi.fn();
+    setProvidedFlue(instrument);
+
+    flueIntegration().setup?.({} as never);
+
+    expect(instrument).toHaveBeenCalledTimes(1);
+  });
+
+  it('does nothing when no Flue binding is on the marker', () => {
+    clearMarker();
+
+    expect(() => flueIntegration().setup?.({} as never)).not.toThrow();
+  });
+
+  it('swallows a duplicate registration from an app that also calls instrument()', () => {
+    setProvidedFlue(
+      vi.fn(() => {
+        throw alreadyInstalledError();
+      }),
+    );
+
+    expect(() => flueIntegration().setup?.({} as never)).not.toThrow();
+  });
+
+  it('warns but never throws when registration fails for any other reason', () => {
+    // `setup()` runs inside `Sentry.init()`, which core calls unguarded — throwing would take
+    // down the Cloudflare request handler.
+    const warn = vi.spyOn(debug, 'warn').mockImplementation(() => undefined);
+    const error = new TypeError('instrument is not a function');
+    setProvidedFlue(
+      vi.fn(() => {
+        throw error;
+      }),
+    );
+
+    expect(() => flueIntegration().setup?.({} as never)).not.toThrow();
+    expect(warn).toHaveBeenCalledWith(expect.stringContaining('[Flue] auto-registration failed'), error);
+  });
+});
diff --git a/packages/server-utils/test/orchestrion/config.test.ts b/packages/server-utils/test/orchestrion/config.test.ts
index 78d489dc2175..3d9a76415b9c 100644
--- a/packages/server-utils/test/orchestrion/config.test.ts
+++ b/packages/server-utils/test/orchestrion/config.test.ts
@@ -64,6 +64,21 @@ describe('orchestrion config — channel-subscriber coverage', () => {
   });
 });
 
+describe('orchestrion config — Flue', () => {
+  it('transforms @flue/runtime', () => {
+    expect(SENTRY_INSTRUMENTATIONS.map(i => i.module.name)).toContain('@flue/runtime');
+  });
+
+  it('is force-bundled as a side effect of being instrumented', () => {
+    expect(INSTRUMENTED_MODULE_NAMES).toContain('@flue/runtime');
+  });
+
+  // Registration-only configs carry a custom transform the runtime loader cannot apply.
+  it('excludes @flue/runtime from the runtime loader', () => {
+    expect(SENTRY_RUNTIME_INSTRUMENTATIONS.map(i => i.module.name)).not.toContain('@flue/runtime');
+  });
+});
+
 describe('orchestrion config — custom instrumentations', () => {
   const customInstrumentation = { module: { name: 'my-lib' } } as InstrumentationConfig;