diff --git a/src/coreclr/vm/comdelegate.cpp b/src/coreclr/vm/comdelegate.cpp
index a26e71dab0fad4..ac41bcefaff092 100644
--- a/src/coreclr/vm/comdelegate.cpp
+++ b/src/coreclr/vm/comdelegate.cpp
@@ -815,6 +815,8 @@ static PCODE CreateILDelegateShuffleThunk(MethodDesc* pDelegateMD, bool callTarg
 
     pCode->EmitLoadThis();
     pCode->EmitLDFLD(pCode->GetToken(CoreLibBinder::GetField(FIELD__DELEGATE__METHOD_PTR_AUX)));
+    // TODO: For open virtual delegates, _methodPtrAux is a dispatch stub that expects the address of _methodPtrAux in a
+    // hidden argument, which calli does not pass: https://github.com/dotnet/runtime/issues/134733
     pCode->EmitCALLI(TOKEN_ILSTUB_TARGET_SIG, sig.NumFixedArgs(), sig.IsReturnTypeVoid() ? 0 : 1);
     pCode->EmitRET();
 
diff --git a/src/coreclr/vm/interpexec.cpp b/src/coreclr/vm/interpexec.cpp
index 70d5928cb5820e..0e21a28c23b16d 100644
--- a/src/coreclr/vm/interpexec.cpp
+++ b/src/coreclr/vm/interpexec.cpp
@@ -1358,6 +1358,21 @@ static void ShiftDelegateCallArgs(int8_t* stack, int32_t callArgsOffset, int32_t
     }
 }
 
+// Resolves the target of an open virtual delegate for the given 'this' argument.
+static MethodDesc* ResolveOpenVirtualDelegateTarget(DELEGATEREF delegateObj, OBJECTREF* pThisArg)
+{
+    MethodDesc* pDeclMD = COMDelegate::GetMethodDescForOpenVirtualDelegate(delegateObj);
+    return CallWithSEHWrapper(
+        [pDeclMD, pThisArg]() {
+            MethodTable* pMT = (*pThisArg)->GetMethodTable();
+            MethodDesc* pTarget;
+            GCX_PREEMP_REGION_BEGIN();
+            pTarget = pDeclMD->GetMethodDescOfVirtualizedCode(pThisArg, pMT, pDeclMD->GetMethodTable());
+            GCX_PREEMP_REGION_END();
+            return pTarget;
+        });
+}
+
 static void UpdateFrameForTailCall(InterpMethodContextFrame *pFrame, PTR_InterpByteCodeStart targetIp, int8_t *callArgsAddress)
 {
     InterpMethod *pTargetMethod = targetIp->Method;
@@ -3376,6 +3391,24 @@ void InterpExecMethod(InterpreterFrame *pInterpreterFrame, InterpMethodContextFr
                             InvokeUnmanagedCalliWithTransition(calliFunctionPointer, cookie, stack, pFrame, callArgsAddress, returnValueAddress);
                         }
                     }
+#ifdef FEATURE_CACHED_INTERFACE_DISPATCH
+                    else if (calliFunctionPointer == (PCODE)CID_VirtualOpenDelegateDispatch)
+                    {
+                        // For an open virtual delegate, _methodPtrAux is CID_VirtualOpenDelegateDispatch,
+                        // which expects the address of _methodPtrAux in a hidden argument that calli cannot
+                        // express; resolve the target as INTOP_CALLDELEGATE does.
+                        // Workaround for https://github.com/dotnet/runtime/issues/134733.
+
+                        // The shuffle thunk's 'this' is the delegate.
+                        DELEGATEREF delegateObj = LOCAL_VAR(0, DELEGATEREF);
+                        _ASSERTE(((MethodDesc*)pMethod->methodHnd)->IsILStub() && ((MethodDesc*)pMethod->methodHnd)->AsDynamicMethodDesc()->IsDelegateShuffleThunk());
+                        _ASSERTE(delegateObj != NULL && delegateObj->GetMethodPtrAux() == calliFunctionPointer);
+                        OBJECTREF *pThisArg = (OBJECTREF*)callArgsAddress;
+                        NULL_CHECK(*pThisArg);
+                        targetMethod = ResolveOpenVirtualDelegateTarget(delegateObj, pThisArg);
+                        goto CALL_INTERP_METHOD;
+                    }
+#endif // FEATURE_CACHED_INTERFACE_DISPATCH
 #ifndef FEATURE_PORTABLE_ENTRYPOINTS
 // If we're not using portable entrypoints, we can use NonVirtualEntry2MethodDesc to figure out where tailcalls go. Since this is
 // somewhat expensive, we only do it for tailcalls which are relatively rare.
@@ -3500,18 +3533,9 @@ void InterpExecMethod(InterpreterFrame *pInterpreterFrame, InterpMethodContextFr
 
                         if (isOpenVirtual)
                         {
-                            targetMethod = COMDelegate::GetMethodDescForOpenVirtualDelegate(*delegateObj);
                             OBJECTREF *pThisArg = LOCAL_VAR_ADDR(callArgsOffset + INTERP_STACK_SLOT_SIZE, OBJECTREF);
                             NULL_CHECK(*pThisArg);
-                            targetMethod = CallWithSEHWrapper(
-                                [&targetMethod, &pThisArg]() {
-                                    MethodTable* pMT = (*pThisArg)->GetMethodTable();
-                                    MethodDesc *pTarget;
-                                    GCX_PREEMP_REGION_BEGIN();
-                                    pTarget = targetMethod->GetMethodDescOfVirtualizedCode(pThisArg, pMT, targetMethod->GetMethodTable());
-                                    GCX_PREEMP_REGION_END();
-                                    return pTarget;
-                                });
+                            targetMethod = ResolveOpenVirtualDelegateTarget(*delegateObj, pThisArg);
                         }
                         else
                         {
diff --git a/src/libraries/System.Runtime/tests/System.Runtime.Tests/System/DelegateTests.cs b/src/libraries/System.Runtime/tests/System.Runtime.Tests/System/DelegateTests.cs
index e145ac41227eac..4275fd0f8becaa 100644
--- a/src/libraries/System.Runtime/tests/System.Runtime.Tests/System/DelegateTests.cs
+++ b/src/libraries/System.Runtime/tests/System.Runtime.Tests/System/DelegateTests.cs
@@ -553,6 +553,24 @@ public static void DifferentOpenVirtualDelegates()
             Assert.Equal(m2, b.Method);
         }
 
+        [Fact]
+        public static void OpenVirtualDelegates_InvokeResolvesOverride()
+        {
+            Func<object, string> toString = typeof(object).GetMethod(nameof(object.ToString)).CreateDelegate<Func<object, string>>();
+            Assert.Equal(nameof(OpenVirtualDerived), toString(new OpenVirtualDerived()));
+            Assert.Equal(typeof(Struct).ToString(), toString(new Struct()));
+            Assert.Equal(nameof(DayOfWeek.Monday), toString(DayOfWeek.Monday));
+        }
+
+        [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/134707", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser), nameof(PlatformDetection.IsMonoAOT))]
+        public static void OpenVirtualDelegates_InterfaceMethod_InvokeResolvesImplementation()
+        {
+            Func<IOpenVirtual, int> interfaceMethod = typeof(IOpenVirtual).GetMethod(nameof(IOpenVirtual.M)).CreateDelegate<Func<IOpenVirtual, int>>();
+            Assert.Equal(1, interfaceMethod(new OpenVirtualDerived()));
+            Assert.Equal(2, interfaceMethod(new OpenVirtualStruct()));
+        }
+
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsTypeEquivalenceSupported))]
         public static void TypeEquivalentDelegatesPointingToSameMethod_AreEqualAndHaveSameHashCode()
         {
@@ -588,6 +606,14 @@ internal virtual void M1() { }
             internal virtual void M2() { }
         }
 
+        interface IOpenVirtual { int M(); }
+        class OpenVirtualDerived : IOpenVirtual
+        {
+            public int M() => 1;
+            public override string ToString() => nameof(OpenVirtualDerived);
+        }
+        struct OpenVirtualStruct : IOpenVirtual { public int M() => 2; }
+
         class Base { public virtual void M() { } }
         class Derived : Base { public override void M() { } }
 
diff --git a/src/libraries/tests.proj b/src/libraries/tests.proj
index af586522303251..7bac0a358e42ca 100644
--- a/src/libraries/tests.proj
+++ b/src/libraries/tests.proj
@@ -90,8 +90,6 @@
   <ItemGroup Condition="'$(TargetOS)' == 'browser' and '$(RuntimeFlavor)' == 'CoreCLR' and '$(TestWasmReadyToRun)' == 'true' and '$(PublishReadyToRun)' != 'false' and '$(RunDisabledWasmTests)' != 'true'">
     <!-- ActiveIssue https://github.com/dotnet/runtime/issues/134200 -->
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime\tests\System.Dynamic.Runtime.Tests\System.Dynamic.Runtime.Tests.csproj" />
-    <!-- ActiveIssue https://github.com/dotnet/runtime/issues/134261 -->
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Linq.Expressions\tests\System.Linq.Expressions.Tests.csproj" />
   </ItemGroup>
 
   <!-- Wasm aot on all platforms -->