diff --git a/persistence-typed-tests/src/test/scala/org/apache/pekko/persistence/typed/state/scaladsl/RuntimeDurableStateStoreSpec.scala b/persistence-typed-tests/src/test/scala/org/apache/pekko/persistence/typed/state/scaladsl/RuntimeDurableStateStoreSpec.scala
new file mode 100644
index 00000000000..4dc4bdb9e48
--- /dev/null
+++ b/persistence-typed-tests/src/test/scala/org/apache/pekko/persistence/typed/state/scaladsl/RuntimeDurableStateStoreSpec.scala
@@ -0,0 +1,100 @@
+/*
+ * Licensed to the Apache Software Foundation (ASF) under one or more
+ * contributor license agreements. See the NOTICE file distributed with
+ * this work for additional information regarding copyright ownership.
+ * The ASF licenses this file to You under the Apache License, Version 2.0
+ * (the "License"); you may not use this file except in compliance with
+ * the License. You may obtain a copy of the License at
+ *
+ *    http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+package org.apache.pekko.persistence.typed.state.scaladsl
+
+import org.apache.pekko
+import pekko.Done
+import pekko.actor.testkit.typed.scaladsl.LogCapturing
+import pekko.actor.testkit.typed.scaladsl.ScalaTestWithActorTestKit
+import pekko.actor.typed.ActorRef
+import pekko.actor.typed.Behavior
+import pekko.persistence.state.DurableStateStoreRegistry
+import pekko.persistence.state.scaladsl.DurableStateUpdateStore
+import pekko.persistence.testkit.state.PersistenceTestKitDurableStateStoreProvider
+import pekko.persistence.typed.PersistenceId
+
+import com.typesafe.config.Config
+import com.typesafe.config.ConfigFactory
+import org.scalatest.wordspec.AnyWordSpecLike
+
+object RuntimeDurableStateStoreSpec {
+
+  private object Actor {
+    sealed trait Command
+    final case class Save(text: String, replyTo: ActorRef[Done]) extends Command
+    final case class ShowMeWhatYouGot(replyTo: ActorRef[String]) extends Command
+    case object Stop extends Command
+
+    def apply(persistenceId: String, store: String): Behavior[Command] =
+      DurableStateBehavior[Command, String](
+        PersistenceId.ofUniqueId(persistenceId),
+        "",
+        (state, cmd) =>
+          cmd match {
+            case Save(text, replyTo) =>
+              Effect.persist(Seq(state, text).filter(_.nonEmpty).mkString("|")).thenRun(_ => replyTo ! Done)
+            case ShowMeWhatYouGot(replyTo) =>
+              replyTo ! state
+              Effect.none
+            case Stop =>
+              Effect.stop()
+          })
+        .withDurableStateStorePluginId(s"$store.state")
+        .withDurableStateStorePluginConfig(Some(config(store)))
+  }
+
+  private def config(store: String): Config =
+    ConfigFactory.parseString(s"""
+      $store {
+        state.class = "${classOf[PersistenceTestKitDurableStateStoreProvider].getName}"
+      }
+    """)
+}
+
+class RuntimeDurableStateStoreSpec extends ScalaTestWithActorTestKit with AnyWordSpecLike with LogCapturing {
+
+  import RuntimeDurableStateStoreSpec._
+
+  "The durable state store plugin" must {
+
+    "be possible to configure at runtime and use in multiple isolated instances" in {
+      val probe = createTestProbe[Any]()
+
+      {
+        // one actor in each store with same id
+        val s1 = spawn(Actor("id1", "store1"))
+        val s2 = spawn(Actor("id1", "store2"))
+        s1 ! Actor.Save("s1m1", probe.ref)
+        probe.receiveMessage()
+        s2 ! Actor.Save("s2m1", probe.ref)
+        probe.receiveMessage()
+      }
+
+      {
+        def assertStore(store: String, expectedState: String) = {
+          val durableStateStore = DurableStateStoreRegistry(system)
+            .durableStateStoreFor[DurableStateUpdateStore[String]](s"$store.state", config(store))
+          durableStateStore.getObject("id1").futureValue.value shouldBe Some(expectedState)
+        }
+
+        assertStore("store1", "s1m1")
+        assertStore("store2", "s2m1")
+      }
+    }
+  }
+}
diff --git a/persistence-typed/src/main/mima-filters/2.0.x.backwards.excludes/durablestate-runtime-config.excludes b/persistence-typed/src/main/mima-filters/2.0.x.backwards.excludes/durablestate-runtime-config.excludes
new file mode 100644
index 00000000000..b86dd3685cd
--- /dev/null
+++ b/persistence-typed/src/main/mima-filters/2.0.x.backwards.excludes/durablestate-runtime-config.excludes
@@ -0,0 +1,19 @@
+# Licensed to the Apache Software Foundation (ASF) under one
+# or more contributor license agreements.  See the NOTICE file
+# distributed with this work for additional information
+# regarding copyright ownership.  The ASF licenses this file
+# to you under the Apache License, Version 2.0 (the
+# "License"); you may not use this file except in compliance
+# with the License.  You may obtain a copy of the License at
+#
+#   http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing,
+# software distributed under the License is distributed on an
+# "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+# KIND, either express or implied.  See the License for the
+# specific language governing permissions and limitations
+# under the License.
+
+# Add DurableStateBehavior.withDurableStateStorePluginConfig
+ProblemFilters.exclude[ReversedMissingMethodProblem]("org.apache.pekko.persistence.typed.state.scaladsl.DurableStateBehavior.withDurableStateStorePluginConfig")
diff --git a/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/internal/BehaviorSetup.scala b/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/internal/BehaviorSetup.scala
index c74421ab208..332bc62e258 100644
--- a/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/internal/BehaviorSetup.scala
+++ b/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/internal/BehaviorSetup.scala
@@ -30,6 +30,8 @@ import pekko.persistence.typed.state.internal.InternalProtocol.RecoveryTimeout
 import pekko.persistence.typed.state.scaladsl.DurableStateBehavior
 import pekko.util.OptionVal
 
+import com.typesafe.config.ConfigFactory
+
 import org.slf4j.Logger
 import org.slf4j.MDC
 
@@ -57,7 +59,9 @@ private[pekko] final class BehaviorSetup[C, S](
   // Any instead S because adapter may change the type
   val durableStateStore: DurableStateUpdateStore[Any] =
     DurableStateStoreRegistry(context.system.toClassic)
-      .durableStateStoreFor[DurableStateUpdateStore[Any]](settings.durableStateStorePluginId)
+      .durableStateStoreFor[DurableStateUpdateStore[Any]](
+        settings.durableStateStorePluginId,
+        settings.durableStateStorePluginConfig.getOrElse(ConfigFactory.empty))
 
   def selfClassic: ClassicActorRef = context.self.toClassic
 
diff --git a/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/internal/DurableStateBehaviorImpl.scala b/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/internal/DurableStateBehaviorImpl.scala
index 65061dffe7e..bb6662d07d1 100644
--- a/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/internal/DurableStateBehaviorImpl.scala
+++ b/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/internal/DurableStateBehaviorImpl.scala
@@ -35,6 +35,8 @@ import pekko.persistence.typed.PersistenceId
 import pekko.persistence.typed.SnapshotAdapter
 import pekko.persistence.typed.state.scaladsl._
 
+import com.typesafe.config.Config
+
 import org.slf4j.LoggerFactory
 
 @InternalApi
@@ -60,6 +62,7 @@ private[pekko] final case class DurableStateBehaviorImpl[Command, State](
     commandHandler: DurableStateBehavior.CommandHandler[Command, State],
     loggerClass: Class[?],
     durableStateStorePluginId: Option[String] = None,
+    durableStateStorePluginConfig: Option[Config] = None,
     tag: String = "",
     snapshotAdapter: SnapshotAdapter[State] = NoOpSnapshotAdapter.instance[State],
     supervisionStrategy: SupervisorStrategy = SupervisorStrategy.stop,
@@ -80,7 +83,11 @@ private[pekko] final case class DurableStateBehaviorImpl[Command, State](
       case _                                => false
     }
     if (!hasCustomLoggerName) ctx.setLoggerName(loggerClass)
-    val settings = DurableStateSettings(ctx.system, durableStateStorePluginId.getOrElse(""), customStashCapacity)
+    val settings = DurableStateSettings(
+      ctx.system,
+      durableStateStorePluginId.getOrElse(""),
+      durableStateStorePluginConfig,
+      customStashCapacity)
 
     // stashState outside supervise because StashState should survive restarts due to persist failures
     val stashState = new StashState(ctx.asInstanceOf[ActorContext[InternalProtocol]], settings)
@@ -170,6 +177,9 @@ private[pekko] final case class DurableStateBehaviorImpl[Command, State](
     copy(durableStateStorePluginId = if (id != "") Some(id) else None)
   }
 
+  override def withDurableStateStorePluginConfig(config: Option[Config]): DurableStateBehavior[Command, State] =
+    copy(durableStateStorePluginConfig = config)
+
   override def withTag(tag: String): DurableStateBehavior[Command, State] =
     copy(tag = tag)
 
diff --git a/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/internal/DurableStateSettings.scala b/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/internal/DurableStateSettings.scala
index 33082fcb3df..5071c659a78 100644
--- a/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/internal/DurableStateSettings.scala
+++ b/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/internal/DurableStateSettings.scala
@@ -34,11 +34,25 @@ import com.typesafe.config.Config
       system: ActorSystem[?],
       durableStateStorePluginId: String,
       customStashCapacity: Option[Int]): DurableStateSettings =
-    apply(system.settings.config, durableStateStorePluginId, customStashCapacity)
+    apply(system, durableStateStorePluginId, None, customStashCapacity)
+
+  def apply(
+      system: ActorSystem[?],
+      durableStateStorePluginId: String,
+      durableStateStorePluginConfig: Option[Config],
+      customStashCapacity: Option[Int]): DurableStateSettings =
+    apply(system.settings.config, durableStateStorePluginId, durableStateStorePluginConfig, customStashCapacity)
+
+  def apply(
+      config: Config,
+      durableStateStorePluginId: String,
+      customStashCapacity: Option[Int]): DurableStateSettings =
+    apply(config, durableStateStorePluginId, None, customStashCapacity)
 
   def apply(
       config: Config,
       durableStateStorePluginId: String,
+      durableStateStorePluginConfig: Option[Config],
       customStashCapacity: Option[Int]): DurableStateSettings = {
     val typedConfig = config.getConfig("pekko.persistence.typed")
 
@@ -54,7 +68,8 @@ import com.typesafe.config.Config
 
     val logOnStashing = typedConfig.getBoolean("log-stashing")
 
-    val durableStateStoreConfig = durableStateStoreConfigFor(config, durableStateStorePluginId)
+    val durableStateStoreConfig =
+      durableStateStoreConfigFor(config, durableStateStorePluginId, durableStateStorePluginConfig)
     val recoveryTimeout: FiniteDuration =
       durableStateStoreConfig.getDuration("recovery-timeout", TimeUnit.MILLISECONDS).millis
 
@@ -69,20 +84,26 @@ import com.typesafe.config.Config
       logOnStashing = logOnStashing,
       recoveryTimeout,
       durableStateStorePluginId,
+      durableStateStorePluginConfig,
       useContextLoggerForInternalLogging,
       recurseWhenUnstashingReadOnlyCommands)
   }
 
-  private def durableStateStoreConfigFor(config: Config, pluginId: String): Config = {
+  private def durableStateStoreConfigFor(
+      config: Config,
+      pluginId: String,
+      pluginConfig: Option[Config]): Config = {
+    val mergedConfig = pluginConfig.map(_.withFallback(config)).getOrElse(config)
+
     def defaultPluginId = {
-      val configPath = config.getString("pekko.persistence.state.plugin")
+      val configPath = mergedConfig.getString("pekko.persistence.state.plugin")
       Persistence.verifyPluginConfigIsDefined(configPath, "Default DurableStateStore")
       configPath
     }
 
     val configPath = if (pluginId == "") defaultPluginId else pluginId
-    Persistence.verifyPluginConfigExists(config, configPath, "DurableStateStore")
-    config.getConfig(configPath).withFallback(config.getConfig("pekko.persistence.state-plugin-fallback"))
+    Persistence.verifyPluginConfigExists(mergedConfig, configPath, "DurableStateStore")
+    mergedConfig.getConfig(configPath).withFallback(mergedConfig.getConfig("pekko.persistence.state-plugin-fallback"))
   }
 
 }
@@ -97,6 +118,7 @@ private[pekko] final case class DurableStateSettings(
     logOnStashing: Boolean,
     recoveryTimeout: FiniteDuration,
     durableStateStorePluginId: String,
+    durableStateStorePluginConfig: Option[Config],
     useContextLoggerForInternalLogging: Boolean,
     recurseWhenUnstashingReadOnlyCommands: Boolean) {
 
diff --git a/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/javadsl/DurableStateBehavior.scala b/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/javadsl/DurableStateBehavior.scala
index 54b3b6003af..4af86d9582e 100644
--- a/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/javadsl/DurableStateBehavior.scala
+++ b/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/javadsl/DurableStateBehavior.scala
@@ -28,6 +28,10 @@ import pekko.persistence.typed.SnapshotAdapter
 import pekko.persistence.typed.state.internal
 import pekko.persistence.typed.state.internal._
 import pekko.persistence.typed.state.scaladsl
+
+import scala.jdk.OptionConverters._
+
+import com.typesafe.config.Config
 import org.jspecify.annotations.Nullable
 
 /**
@@ -114,6 +118,14 @@ abstract class DurableStateBehavior[Command, State] private[pekko] (
    */
   def durableStateStorePluginId: String = ""
 
+  /**
+   * Override and define the `DurableStateStore` plugin config that this actor should use instead of the default.
+   * This is useful when the same plugin class is configured for multiple, isolated stores at runtime.
+   *
+   * @since 2.0.0
+   */
+  def durableStateStorePluginConfig: Optional[Config] = Optional.empty()
+
   /**
    * The tag that can be used in persistence query.
    */
@@ -140,7 +152,11 @@ abstract class DurableStateBehavior[Command, State] private[pekko] (
       persistenceId,
       emptyState,
       (state, cmd) => commandHandler()(state, cmd).asInstanceOf[EffectImpl[State]],
-      getClass).withTag(tag).snapshotAdapter(snapshotAdapter()).withDurableStateStorePluginId(durableStateStorePluginId)
+      getClass)
+      .withTag(tag)
+      .snapshotAdapter(snapshotAdapter())
+      .withDurableStateStorePluginId(durableStateStorePluginId)
+      .withDurableStateStorePluginConfig(durableStateStorePluginConfig.toScala)
 
     val handler = signalHandler()
     val behaviorWithSignalHandler =
diff --git a/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/scaladsl/DurableStateBehavior.scala b/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/scaladsl/DurableStateBehavior.scala
index ec44f3abfab..3a014744bfd 100644
--- a/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/scaladsl/DurableStateBehavior.scala
+++ b/persistence-typed/src/main/scala/org/apache/pekko/persistence/typed/state/scaladsl/DurableStateBehavior.scala
@@ -15,6 +15,8 @@ package org.apache.pekko.persistence.typed.state.scaladsl
 
 import scala.annotation.tailrec
 
+import com.typesafe.config.Config
+
 import org.apache.pekko
 import pekko.actor.typed.BackoffSupervisorStrategy
 import pekko.actor.typed.Behavior
@@ -146,6 +148,14 @@ object DurableStateBehavior {
    */
   def withDurableStateStorePluginId(id: String): DurableStateBehavior[Command, State]
 
+  /**
+   * Change the `DurableStateStore` plugin config that this actor should use.
+   * This is useful when the same plugin class is configured for multiple, isolated stores at runtime.
+   *
+   * @since 2.0.0
+   */
+  def withDurableStateStorePluginConfig(config: Option[Config]): DurableStateBehavior[Command, State]
+
   /**
    * The tag that can used in persistence query
    */
diff --git a/persistence/src/main/scala/org/apache/pekko/persistence/state/DurableStateStoreRegistry.scala b/persistence/src/main/scala/org/apache/pekko/persistence/state/DurableStateStoreRegistry.scala
index 64beff8d510..5ff8014ec78 100644
--- a/persistence/src/main/scala/org/apache/pekko/persistence/state/DurableStateStoreRegistry.scala
+++ b/persistence/src/main/scala/org/apache/pekko/persistence/state/DurableStateStoreRegistry.scala
@@ -30,6 +30,7 @@ import pekko.persistence.PluginProvider
 import pekko.persistence.state.scaladsl.DurableStateStore
 
 import com.typesafe.config.Config
+import com.typesafe.config.ConfigFactory
 
 /**
  * Persistence extension for queries.
@@ -67,9 +68,12 @@ class DurableStateStoreRegistry(system: ExtendedActorSystem)
     configPath
   }
 
-  private def pluginIdOrDefault(pluginId: String): String = {
+  private def pluginIdOrDefault(pluginId: String): String =
+    pluginIdOrDefault(pluginId, ConfigFactory.empty)
+
+  private def pluginIdOrDefault(pluginId: String, pluginConfig: Config): String = {
     val configPath = if (isEmpty(pluginId)) defaultPluginId else pluginId
-    Persistence.verifyPluginConfigExists(systemConfig, configPath, "DurableStateStore")
+    Persistence.verifyPluginConfigExists(pluginConfig.withFallback(systemConfig), configPath, "DurableStateStore")
     configPath
   }
 
@@ -91,6 +95,17 @@ class DurableStateStoreRegistry(system: ExtendedActorSystem)
     pluginFor(pluginIdOrDefault(pluginId), pluginConfig(pluginId)).scaladslPlugin.asInstanceOf[T]
   }
 
+  /**
+   * Scala API: Returns the [[pekko.persistence.state.scaladsl.DurableStateStore]] specified by the given
+   * configuration entry. The provided `pluginConfig` is used to configure the plugin at runtime, taking
+   * precedence over the plugin configuration defined in the actor system configuration.
+   *
+   * @since 2.0.0
+   */
+  final def durableStateStoreFor[T <: scaladsl.DurableStateStore[?]](pluginId: String, pluginConfig: Config): T = {
+    pluginFor(pluginIdOrDefault(pluginId, pluginConfig), pluginConfig).scaladslPlugin.asInstanceOf[T]
+  }
+
   /**
    * Java API: Returns the [[pekko.persistence.state.javadsl.DurableStateStore]] specified by the given
    * configuration entry.
@@ -101,4 +116,18 @@ class DurableStateStoreRegistry(system: ExtendedActorSystem)
     pluginFor(pluginIdOrDefault(pluginId), pluginConfig(pluginId)).javadslPlugin.asInstanceOf[T]
   }
 
+  /**
+   * Java API: Returns the [[pekko.persistence.state.javadsl.DurableStateStore]] specified by the given
+   * configuration entry. The provided `pluginConfig` is used to configure the plugin at runtime, taking
+   * precedence over the plugin configuration defined in the actor system configuration.
+   *
+   * @since 2.0.0
+   */
+  final def getDurableStateStoreFor[T <: javadsl.DurableStateStore[?]](
+      @nowarn("msg=never used") clazz: Class[T], // FIXME generic Class could be problematic in Java
+      pluginId: String,
+      pluginConfig: Config): T = {
+    pluginFor(pluginIdOrDefault(pluginId, pluginConfig), pluginConfig).javadslPlugin.asInstanceOf[T]
+  }
+
 }