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    <title>Simina blog</title>
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    <description>Recent content on Simina blog</description>
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      <title>A simulation approach to understanding Coronavirus mortality</title>
      <link>/2020/03/19/a-simulation-approach-to-understand-coronavirus-mortality/</link>
      <pubDate>Thu, 19 Mar 2020 00:00:00 +0000</pubDate>
      
      <guid>/2020/03/19/a-simulation-approach-to-understand-coronavirus-mortality/</guid>
      <description>With the Coronavirus crisis currently being a global emergency, one question that has been asked over and over again is “What is the chance of dying if I contract this virus?” This is not an easy question to answer and we know that it depends on issues like an individual’s age (older individuals are much more likely to be affected than younger individuals) and how well a specific country’s healthcare system is working (including how overburdened it is during the current crisis).</description>
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      <title>The prime number theorem: Explorations in R</title>
      <link>/2019/06/22/the-prime-number-theorem-explorations-in-r/</link>
      <pubDate>Sat, 22 Jun 2019 00:00:00 +0000</pubDate>
      
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      <description>Prime numbers
A prime number is defined as a number greater than 1 that is only divisible by 1 and itself.
Thus, 2, 3, 5, and 7 are all primes, but the following are not:
4 = 2 x 2
6 = 3 x 2
8 = 2 x 2 x 2
9 = 3 x 3
In fact, no even numbers greater than 2 are primes, given that they are all divisible by 2.</description>
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      <title>Bayes&#39;s rule in practice: CF carrier testing</title>
      <link>/2019/02/07/bayes-s-rule-in-practice-cf-carrier-testing/</link>
      <pubDate>Thu, 07 Feb 2019 00:00:00 +0000</pubDate>
      
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      <description>Cystic fibrosis (CF) is a recessive genetic disorder which is the most common life-limiting genetic disorder amongst Caucasians. I have written before about how improved management of the disease has led to substantial improvements in life expectancy and quality of life, in large part due to its inclusion in newborn screening programs. More recently, it is becoming increasingly common to also offer pregnant women a genetic test to see if they are carriers of a CF-causing mutation in the CFTR gene.</description>
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      <title>2018: Year in review</title>
      <link>/2018/12/10/year-in-review/</link>
      <pubDate>Mon, 10 Dec 2018 00:00:00 +0000</pubDate>
      
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      <description>Research careers often entail relatively few concrete achievements over relatively long periods of time. Even when something good happens, it feels like rejection is right around the corner. To cheer up during the long stretches of waiting and the many rejections, I decided at the beginning of 2018 to keep a running list of achievements. I wanted to include products that weren&amp;rsquo;t necessarily full-fledged papers, including blog posts, talk acceptances, big grant submissions (not just acceptances, since those are way rare!</description>
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      <title>Omics exploratory data analysis checklist</title>
      <link>/2018/09/05/omics-exploratory-data-analysis-checklist/</link>
      <pubDate>Wed, 05 Sep 2018 00:00:00 +0000</pubDate>
      
      <guid>/2018/09/05/omics-exploratory-data-analysis-checklist/</guid>
      <description>This is a non-exhaustive checklist of exploratory data analysis (EDA) checks I do for omics datasets + any associated demographic or meta-data, as a first step (after some basic reading in the data and basic preprocessing.) There are many resources for this. I am personally indebted to my Rafa Irizarry, Jeff Leek, Roger Peng, Karl Broman among others for many of these tips. Note that I tend to spend maybe 90% of total analysis time doing this kind of EDA and don&amp;rsquo;t usually start doing much modeling until I do at least an initial first pass of EDA and discuss results with the rest of the team and/or investigators who generated the data/provided the samples.</description>
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      <title>Tips on making presentation slides</title>
      <link>/2018/02/09/tips-on-making-presentation-slides/</link>
      <pubDate>Fri, 09 Feb 2018 00:00:00 +0000</pubDate>
      
      <guid>/2018/02/09/tips-on-making-presentation-slides/</guid>
      <description>Below is a non-exhaustive list of recommendation on making presentation slides, focusing on presenting biostatistics or bioinformatics projects. There are many amazing resources out there. I internalized much of the advice given to me by many awesome official and unofficial mentors (Jeff Leek, Giovanni Parmigiani, Josh Sampson, Tom Louis, @theeffortreport with Roger Peng and Elizabeth Matsui, and @NSSDeviations with Hilary Parker and Roger Peng, to list a few) and the goal here is to pass some of it along to my students rather than to come up with a comprehensive list.</description>
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      <title>Everything in statistical modeling can be seen as a regression</title>
      <link>/2018/01/10/everything-in-statistical-modeling-can-be-seen-as-a-regression/</link>
      <pubDate>Wed, 10 Jan 2018 00:00:00 +0000</pubDate>
      
      <guid>/2018/01/10/everything-in-statistical-modeling-can-be-seen-as-a-regression/</guid>
      <description>This is of course a bit of an exaggeration! It also depends on the way things are emphasized in, for example, statistical
graduate programs. I know that my own training program was highly focused on seeing much of statistics as either a
special case or a generalization of some kind of linear regression model. I kind of love this view and try to emphasize it whenever I can
to collaborators, although I do admit that sometimes you have to start from special cases in order to build up the whole.</description>
    </item>
    
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      <title>About</title>
      <link>/about/</link>
      <pubDate>Thu, 05 May 2016 21:48:51 -0700</pubDate>
      
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      <description>This is a &amp;ldquo;hello world&amp;rdquo; example website for the blogdown package. The theme was forked from @jrutheiser/hugo-lithium-theme and modified by Yihui Xie.</description>
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