curated_data.csv

gene1,gene2,interaction_strength,description,major_disease,biogrid_score,string_score
KRT15,KRT6C,weak,"Both KRT15 and KRT6C are keratin genes involved in the structural integrity of epithelial cells, but specific functional interactions between them are not well-documented.",Not specified,0.18898085217110117,0.283
CEACAM5,MSLN,strong,"CEACAM5 and MSLN are both associated with cancer progression and are often overexpressed in certain types of cancer, such as gastric and cervical cancers. They may have synergistic roles in tumorigenesis, making them potential biomarkers for cancer detection and therapy.","Cancer, including gastric and cervical cancer",0.0,0.791
PKP1,S100A14,weak,"Based on the provided STRING score of 0.232, there is a suggestion of a weak interaction.  However, the BioGRID score is 0 and there are no PubMed abstracts, indicating a lack of supporting evidence for a strong interaction.",,0.0,0.232
AGR2,AGR3,weak,"Both AGR2 and AGR3 are members of the protein disulfide isomerase family and have been implicated in carcinogenesis.  The STRING score is below the high-confidence threshold, and the BioGRID score is 0.  While PubMed abstracts mention them together in the context of cancer, this is not sufficient evidence to establish a strong interaction.",Cancer,0.0,0.661
SFN,SOX2,weak,"SFN may influence cancer stem cell phenotypes, potentially interacting with SOX2, a marker of stemness in cancer cells, but direct interaction evidence is limited",Cancer,0.124909548940367,0.372
KRT19,KRT6C,weak,"Both KRT19 and KRT6C are keratin genes involved in the structural integrity of epithelial cells, but specific direct interactions between them are not well-documented.",Squamous cell carcinoma,0.18898085217110117,0.215
AGR2,SPDEF,strong,"AGR2 and SPDEF are known to co-operate in the regulation of mucin production and epithelial cell differentiation, which are critical processes in certain types of adenocarcinomas.",adenocarcinoma,0.0,0.784
FOXA1,SPDEF,strong,"FOXA1 and SPDEF are known to be involved in the regulation of gene expression in hormone-responsive cancers, particularly prostate and breast cancer. FOXA1 acts as a pioneer factor facilitating the binding of transcription factors like SPDEF to chromatin, influencing the expression of genes involved in cancer progression.","breast cancer, prostate cancer",0.0,0.709
KRT17,KRT6B,strong,"KRT17 and KRT6B are both keratin proteins often co-expressed in epithelial tissues. Their interaction is important in the structural integrity of skin and epithelial cells, and they are known to participate in the pathogenesis of skin disorders such as Pachyonychia Congenita.",Pachyonychia Congenita,0.124909548940367,0.874
KRT14,KRT6B,strong,"KRT14 and KRT6B are both keratin genes which often co-express in epithelial tissues, playing critical roles in maintaining the structural integrity of keratinocytes. Their interaction is crucial in skin physiology and pathology.","skin disorders, including skin cancer and epithelial cell-related conditions",0.124909548940367,0.835
KRT5,MUC13,weak,"Based on the provided evidence, there is limited support for a direct interaction between KRT5 and MUC13. The STRING score is low (0.213), and the BioGRID score is 0.  The PubMed abstract mentions both genes in the context of Barrett's esophagus, suggesting potential co-occurrence or indirect association in this disease context but not a direct interaction. More evidence is needed to confirm a direct interaction.",Barrett's esophagus,0.0,0.213
ANXA8,TSPAN8,weak,"Based on the provided STRING score of 0.23 and a BioGRID score of 0, along with the absence of PubMed abstracts, the evidence for a direct interaction between ANXA8 and TSPAN8 is weak.  Further investigation is needed to confirm any interaction.",,0.0,0.23
LCN2,LRP2,strong,"LCN2 is known to interact with LRP2 in the context of binding and uptake processes. LRP2, also known as megalin, is a receptor that mediates the endocytosis of various ligands, including LCN2, which is involved in innate immunity and acts as a transporter for small molecules. The interaction between LCN2 and LRP2 is significant in physiological processes such as iron transport and cellular uptake of LCN2-bound molecules.",Cardiometabolic disorders,0.0,0.984
CFTR,SPDEF,weak,"Based on the provided evidence, there is a weak suggestion of an interaction between CFTR and SPDEF.  The STRING score of 0.297 is below the high-confidence threshold. The BioGRID score is 0, indicating no interaction found in that database.  The PubMed abstracts mention CFTR in relation to goblet cell hyperplasia and mucus production, which are processes that SPDEF, a transcription factor, is known to regulate. However, the abstracts do not directly implicate a functional interaction between the two genes. Therefore, the interaction strength is classified as weak.",Cystic Fibrosis,0.0,0.297
ESRP1,GRHL2,weak,"ESRP1 and GRHL2 may be involved in epithelial-mesenchymal transition (EMT) processes, as suggested by PubMed abstracts, but direct interaction evidence is limited","Adenomyosis, Lung diseases",0.0,0.891
DSC3,KRT17,weak,"Based on the provided evidence, there is weak evidence for an interaction between DSC3 and KRT17. The STRING score is 0.431, which is below the threshold for high confidence, and the BioGRID score is 0.  The PubMed abstract mentions these genes in the context of breast cancer metastasis but does not describe a direct interaction.",Breast Cancer,0.0,0.431
DSG3,KRT16,weak,"Based on the provided evidence, there is a weak interaction between DSG3 and KRT16. The STRING score of 0.57 is below the threshold for high confidence (0.7), and the BioGRID score is 0.  The PubMed abstract mentions lung squamous cell carcinoma, but doesn't provide direct evidence of interaction between these two genes.",Lung squamous cell carcinoma,0.0,0.57
AGR2,TFF1,strong,AGR2 and TFF1 are both involved in mucosal protection and are often co-expressed in gastric tissues. They play a role in protecting the gastric mucosa and are implicated in cancer biology.,Pancreatic adenocarcinoma,0.0,0.786
TMPRSS4,TRIM29,weak,"Based on the provided evidence, the STRING score suggests a weak interaction (0.254).  The BioGRID score is 0, indicating no interaction detected in that database.  The PubMed abstract mentions both genes in the context of pancreatic adenocarcinoma, but doesn't describe a direct interaction.",Pancreatic Adenocarcinoma,0.0,0.254
DSC3,KRT13,weak,"Based on the provided STRING score of 0.286, there is a weak interaction between DSC3 and KRT13.  The BioGRID score is 0, and no PubMed abstracts were found, further supporting a weak interaction or lack of strong evidence for a direct interaction.",,0.0,0.286
KRT14,KRT17,strong,KRT14 and KRT17 are both keratins involved in the structural integrity and function of epithelial cells. They are co-expressed in certain types of epithelial tissues and play a role in the cellular stress response. Their interaction is crucial in maintaining cellular structure and function under stress conditions.,"Skin disorders such as epidermolysis bullosa and pachyonychia congenita, where mutations or dysregulation of these keratins can lead to disease.",0.124909548940367,0.814
FOXA1,TFF1,strong,"FOXA1 is a transcription factor that regulates the expression of TFF1, playing a role in breast cancer progression and response to therapy",Breast Cancer,0.124909548940367,0.88
KRT15,KRT5,strong,KRT15 and KRT5 are both keratins that form part of the intermediate filament proteins in epithelial cells. They are involved in providing structural support and integrity to the skin and other epithelial tissues. Their interaction is essential for maintaining the proper function and resilience of the epidermis.,"Skin disorders, including epidermolysis bullosa and other skin fragility conditions, may be associated with mutations or dysregulation in keratin genes.",0.23239274157331358,0.749
CEACAM5,KRT7,weak,"Based on the provided STRING score of 0.883, there is a suggestion of an interaction. However, the BioGRID score is 0, and the PubMed abstracts do not offer direct evidence of a functional interaction between CEACAM5 and KRT7.  Therefore, the interaction strength is classified as weak.",Pancreatic Cancer,0.0,0.883
AGR2,RAB25,weak,"The interaction between AGR2 and RAB25 is not well-documented, but both genes have been implicated in cancer progression and resistance mechanisms.",Cancer,0.124909548940367,0.409
KRT19,KRT5,weak,"Both KRT19 and KRT5 are keratin genes involved in the structural integrity of epithelial cells, but the provided evidence does not strongly support a direct functional interaction between them.",Not specified,0.18898085217110117,0.339
SFTPB,SPDEF,weak,"Based on the provided evidence, there is a weak interaction between SFTPB and SPDEF.  The STRING score of 0.217 is below the threshold for high confidence, and the BioGRID score is 0.  While a PubMed abstract mentions both genes in the context of lung disease, it doesn't describe a direct interaction. Therefore, the interaction is classified as weak.",Lung diseases,0.0,0.217
DSC3,SOX2,weak,"Based on the available evidence, there is a weak interaction between DSC3 and SOX2. The STRING score is below the high confidence threshold, and the BioGRID score indicates moderate strength, but not high strength. No specific PubMed abstracts were found to further elucidate the interaction.",,0.124909548940367,0.415
KRT5,SOX2,weak,"Limited evidence suggests potential interaction between KRT5 and SOX2, but the exact nature of their relationship is not well-characterized",Not specified,0.124909548940367,0.673
DSG3,SPRR3,weak,"The interaction between DSG3 and SPRR3 is not well-documented in the literature. The STRING score suggests a possible association, but the lack of BioGRID score and PubMed abstracts indicates limited evidence.",Not specified,0.0,0.702
KRT19,SFN,weak,"KRT19 and SFN may be involved in cellular processes related to cancer, but direct interaction evidence is limited",Cancer,0.124909548940367,0.438
KRT13,KRT16,weak,"Both KRT13 and KRT16 are keratin genes involved in epithelial differentiation and may co-express in certain tissues, but direct interaction evidence is limited",Epithelial disorders,0.0,0.596
OLFM4,REG1A,weak,"Based on the provided evidence, the STRING score is 0.395, which is below the high-confidence threshold of >0.7. The BioGRID score is 0, indicating no interaction.  One PubMed abstract mentions both genes in the context of ulcerative colitis, but this alone is insufficient to establish a strong interaction. Therefore, the interaction is classified as weak.",Ulcerative Colitis,0.0,0.395
AGR2,SFN,weak,"The interaction between AGR2 and SFN is not well-documented in the provided evidence, with a low STRING score and no direct mention in PubMed abstracts.",Lung adenocarcinoma,0.124909548940367,0.386
KRT16,KRT6B,strong,"KRT16 and KRT6B are keratin genes that are co-expressed and interact in the formation of keratin filaments, playing a critical role in skin integrity. Mutations or dysfunctions in these genes are associated with skin disorders such as Pachyonychia Congenita (PC), characterized by hypertrophic nails and palmoplantar keratoderma.",Pachyonychia Congenita,0.18898085217110117,0.938
KRT16,KRT7,weak,"Both KRT16 and KRT7 are keratin genes involved in epithelial cell structure and differentiation, but the provided evidence does not strongly support a direct functional interaction between them.",Epithelial disorders,0.124909548940367,0.599
ESRP1,S100A14,weak,"Based on the provided STRING score of 0.397 and a BioGRID score of 0, along with a PubMed abstract that doesn't directly describe an interaction, the interaction strength is considered weak.  Further investigation is needed to confirm a direct interaction between ESRP1 and S100A14.",,0.0,0.397
TSPAN8,UPK1B,weak,"Based on a STRING score of 0.272 and a BioGRID score of 0, the interaction between TSPAN8 and UPK1B is weak.  Further research is needed to confirm a significant interaction.",,0.0,0.272
KIF1A,SOX2,weak,"Based on the provided STRING score of 0.267, there is a suggestion of a weak interaction between KIF1A and SOX2.  However, the BioGRID score of 0 and lack of PubMed abstracts do not support a stronger interaction.",,0.0,0.267
FOXA1,KLK3,weak,"The evidence indicates a potential but limited interaction between FOXA1 and KLK3. FOXA1 is a transcription factor that may play a role in the regulation of KLK3 expression, particularly in the context of prostate cancer. However, the available STRING and BioGRID scores do not support a strong interaction.",prostate cancer,0.0,0.537
FGA,FGG,strong,"FGA and FGG are both subunits of fibrinogen, a blood plasma protein that's critical for clot formation. Mutations in these genes can lead to congenital fibrinogen disorders, such as afibrinogenemia.","Congenital fibrinogen disorders (CFDs), including afibrinogenemia",0.18898085217110117,0.999
LCN2,OLFM4,strong,"LCN2 and OLFM4 are both involved in inflammatory responses and immune regulation, with evidence suggesting their potential roles in conditions like ulcerative colitis and sepsis-induced ARDS.","Ulcerative colitis, Sepsis-induced ARDS",0.0,0.856
KRT7,TFF3,weak,"KRT7 and TFF3 are co-expressed in certain conditions like Barrett's esophagus and cholangiocarcinoma, but there is no strong evidence of a direct functional interaction","Barrett's esophagus, Cholangiocarcinoma",0.0,0.307
CEACAM5,GPX2,weak,"Based on the provided STRING score of 0.273, there is a suggestion of a weak interaction between CEACAM5 and GPX2.  However, the lack of supporting evidence from BioGRID and PubMed abstracts limits confidence in the strength of this interaction.",,0.0,0.273
FXYD3,GRHL2,weak,"Based on the STRING score of 0.272, there is a weak interaction between FXYD3 and GRHL2.  The BioGRID score is 0 and there are no PubMed abstracts, indicating a lack of further supporting evidence for a strong interaction.",,0.0,0.272
KRT14,KRT16,strong,"KRT14 and KRT16 are both keratin genes that are co-expressed and involved in the structural integrity of epithelial cells. Their high STRING score suggests a strong functional association, likely in the context of epithelial cell stress response and pathology.","Skin diseases, including epidermolysis bullosa simplex and pachyonychia congenita",0.0,0.868
KRT6B,KRT7,weak,"KRT6B and KRT7 are both keratins involved in the structural integrity of epithelial cells. While they are co-located on chromosome 12 and may be co-expressed in some epithelial tissues, direct interactions between them are not strongly supported by STRING or BioGRID scores. Their functional relationship may be more related to their roles as structural components rather than direct interaction.",,0.124909548940367,0.462
KRT16,KRT17,strong,"KRT16 and KRT17 are both keratins that are co-expressed in various tissues and are involved in the structural integrity of epithelial cells. They are known to interact physically and functionally, particularly in stress responses and pathological conditions.","Skin diseases, Cancer",0.124909548940367,0.88
KRT13,SPRR3,weak,"Both KRT13 and SPRR3 are involved in epithelial cell differentiation and are co-expressed in certain contexts, but direct interaction evidence is limited","Esophageal squamous cell carcinoma, Head and neck squamous cell carcinoma",0.0,0.759
CEACAM5,KLK3,weak,"CEACAM5 and KLK3 do not have direct interactions based on provided evidence. Both genes are involved in cancer pathways, with CEACAM5 commonly associated with colorectal cancer and KLK3 with prostate cancer. The STRING score indicates a potential indirect association or shared pathway involvement.",cancer,0.0,0.837
KRT19,SERPINB5,weak,"Based on the provided evidence, there is weak evidence suggesting an interaction between KRT19 and SERPINB5. The STRING score is 0.39, which is below the high-confidence threshold. The BioGRID score is 0.  The PubMed abstracts mention both genes in the context of cancer but do not describe a direct interaction.",Cancer,0.0,0.39
DSG3,KRT6B,strong,"DSG3 and KRT6B are both involved in epithelial cell differentiation and structural integrity, particularly in skin and mucosal tissues. They may play a role in cell adhesion and keratinization processes.",Lung squamous cell carcinoma,0.0,0.786
S100A14,TACSTD2,weak,"Based on the provided evidence, there is a weak interaction between S100A14 and TACSTD2.  The STRING score of 0.32 suggests a weak interaction, and the BioGRID score of 0 indicates no interaction in that database.  The PubMed abstract mentions both genes in the context of esophageal squamous cell carcinoma metastasis, suggesting possible co-expression or involvement in related pathways, but this is not definitive evidence of a direct interaction.",Esophageal Squamous Cell Carcinoma,0.0,0.32
TFF1,TFF3,strong,"TFF1 and TFF3 are both part of the trefoil factor family, which are secretory peptides involved in maintaining gastrointestinal mucosal integrity and homeostasis. They are known to regulate diverse physiological processes and may have a complementary or synergistic role in tissue repair and cellular protection, particularly in the gastrointestinal tract.",Colorectal cancer,0.0,0.791
SFTPB,TFF3,weak,"Based on the provided PubMed abstracts, both SFTPB and TFF3 are expressed in thyroid tissue and are being investigated as potential markers for papillary thyroid carcinoma.  However, the abstracts do not describe a direct interaction between the two genes. The STRING and BioGRID scores are low, further supporting a weak or absent direct interaction.",Papillary Thyroid Carcinoma,0.0,0.152
COL17A1,KRT14,strong,"COL17A1 and KRT14 are both involved in skin integrity and function. COL17A1, a component of the hemidesmosomes, and KRT14, a type I keratin, interact to maintain epidermal adhesion and resilience. Mutations or disruptions in these genes can lead to skin blistering disorders.",Epidermolysis bullosa,0.0,0.839
COL17A1,DSG3,strong,"COL17A1 and DSG3 are both involved in cell adhesion processes and are known to interact in the epidermal cell junctions, playing a crucial role in maintaining the integrity of the skin barrier. Mutations or dysfunction in these interactions can lead to skin diseases such as pemphigus and epidermolysis bullosa.","Pemphigus, Epidermolysis Bullosa",0.0,0.815
S100A14,TFF3,weak,"Based on the provided evidence, there is a weak suggestion of an interaction between S100A14 and TFF3.  A PubMed abstract mentions both genes in the context of potential serum markers for gynecological tumors, implying a possible co-occurrence or related function, but no direct interaction is described. The STRING score is low (0.205), and the BioGRID score is 0, indicating a lack of strong interaction evidence from those databases.",Gynecological Tumors,0.0,0.205
SERPINB5,SFN,strong,"SERPINB5 and SFN are involved in cancer-related pathways, with evidence suggesting a strong interaction potentially affecting oncogenic signaling pathways and contributing to cancer progression.",cancer,0.124909548940367,0.814
MSLN,MUC16,strong,"MSLN and MUC16 are known to interact significantly in the context of cancer, particularly in promoting tumor progression and metastasis. MSLN is a tumor antigen that is overexpressed in several malignancies, while MUC16 (also known as CA125) is a mucin that is often elevated in ovarian cancer. Their interaction may enhance tumor cell adhesion, invasion, and immune evasion.","cancer, including ovarian cancer and pancreatic ductal adenocarcinoma",0.0,0.995
AGR2,MUC5B,weak,"AGR2 and MUC5B may interact in the context of mucus production and airway diseases, but the evidence is not strong enough to confirm a direct or significant interaction","Lung adenocarcinoma, Asthma",0.18898085217110117,0.726
KRT6A,SPRR3,weak,"The STRING score suggests a potential interaction, but this is not strongly supported by other evidence.  The BioGRID score is 0, and the PubMed abstracts do not provide direct evidence of a functional interaction between KRT6A and SPRR3.",,0.0,0.7
KRT16,KRT23,weak,"Based on the provided evidence, the interaction between KRT16 and KRT23 is weak. The STRING score is 0.48, below the threshold for high confidence. The BioGRID score is 0, indicating no interaction detected.  The PubMed abstract mentions both genes in the context of Barrett's esophagus, suggesting potential co-expression or involvement in the same pathway, but this is not strong evidence of a direct interaction. More evidence is needed to confirm a stronger interaction.",Barrett's esophagus,0.0,0.48
KRT15,LY6D,weak,"Based on the provided STRING score of 0.284, there is a suggestion of a weak interaction between KRT15 and LY6D.  However, the BioGRID score is 0 and there are no PubMed abstracts supporting an interaction. Therefore, the interaction is considered weak.",,0.0,0.284
CALML3,CALML5,strong,"CALML3 and CALML5 are both members of the calmodulin-like protein family, which are involved in calcium signaling pathways. The high STRING score suggests a strong functional association, possibly in calcium-mediated processes.",Not specified,0.0,0.967
GFAP,KRT13,strong,"GFAP and KRT13 are both intermediate filament proteins, which could suggest a structural or functional interaction in certain cellular contexts, though the specifics of their interaction are not well-documented.","Potential involvement in diseases affecting the structural integrity of tissues, such as certain skin or neurological disorders.",0.23239274157331358,0.422
FOXA1,SOX2,strong,"FOXA1 and SOX2 are known to be pioneer transcription factors that cooperate in accessing closed chromatin regions, influencing gene expression and cell fate decisions. This interaction is significant in the context of cancer progression, particularly in tumor lineage plasticity.",cancer,0.0,0.74
KRT13,KRT6B,weak,"Both KRT13 and KRT6B are keratin genes, which are structural proteins involved in epithelial integrity. The provided evidence does not strongly indicate a direct functional interaction between these two specific keratins.",Not specified,0.18898085217110117,0.553
KRT5,PI3,weak,"Based on the provided evidence, there is a weak interaction between KRT5 and PI3. The STRING score of 0.257 suggests a weak interaction, while the BioGRID score is 0, indicating no interaction.  The PubMed abstract mentions both genes in the context of oral squamous cell carcinoma gene expression profiling but does not describe a direct interaction. More evidence is needed to determine the nature of the interaction.",Oral Squamous Cell Carcinoma,0.0,0.257
KRT14,PI3,weak,"Based on the provided evidence, there is a weak interaction between KRT14 and PI3. The STRING score of 0.254 is below the threshold for high confidence, and the BioGRID score is 0.  The PubMed abstracts mention both genes in the context of cancer studies, but do not provide direct evidence of a strong interaction between them.",Cancer,0.0,0.254
GFAP,SOX2,strong,"GFAP and SOX2 are both crucial in the context of neural stem cells and brain repair. GFAP is a marker for glial cells, including astrocytes, while SOX2 is a transcription factor essential for maintaining the self-renewal of undifferentiated stem cells. In neural stem cells, SOX2 expression contributes to the regulation of GFAP expression, particularly in response to injury or in the context of neurogenesis.","Neurodevelopmental disorders, neural repair after injury",0.0,0.805
CEACAM6,TSPAN8,weak,Co-expression in colorectal cancer blood tests.  The STRING and BioGRID scores do not support a direct interaction.,Colorectal Cancer,0.0,0.399
KLK11,PRSS8,weak,"Based on the provided evidence, there is a weak indication of interaction between KLK11 and PRSS8.  The STRING score is 0.241 which is below the threshold for high confidence. The BioGRID score is 0, indicating no interaction found in that database.  One PubMed abstract mentions serine proteases in relation to gastric cancer, but doesn't directly address the interaction between KLK11 and PRSS8. Therefore, more evidence is needed to confirm a stronger interaction.",Gastric Cancer,0.0,0.241
CTSE,LCN2,weak,"Based on the provided evidence, the interaction between CTSE and LCN2 is weak. The STRING score is 0.248, which is below the threshold for high confidence. The BioGRID score is 0, indicating no interaction.  The PubMed abstract mentions both genes in the context of a lung fibrosis model, suggesting a potential indirect or context-dependent relationship, but not a direct strong interaction.",Lung fibrosis,0.0,0.248
KRT5,KRT6B,strong,KRT5 and KRT6B are both keratin proteins that form intermediate filaments in epithelial cells. They interact to maintain structural integrity and resilience of epithelial tissues.,skin disorders such as epidermolysis bullosa simplex and hyperkeratosis,0.124909548940367,0.861
KRT17,KRT7,weak,"Both KRT17 and KRT7 are keratin genes involved in structural functions within epithelial cells, but the provided evidence does not strongly support a direct functional interaction between them.",Cancer,0.18898085217110117,0.472
KRT6A,KRT6B,strong,"KRT6A and KRT6B are keratin proteins that are part of the same gene family and are known to interact in the formation of keratin filaments, which play a critical role in the structural integrity of epithelial cells. They are often co-expressed and can be involved in similar physiological processes and pathological conditions.",Pachyonychia congenita,0.124909548940367,0.886
CEACAM5,MUC16,weak,"Based on the provided evidence, there is a weak interaction between CEACAM5 and MUC16. The STRING score is 0.523 which is below the threshold for high confidence. The BioGRID score is 0.  The PubMed abstract mentions both genes in the context of ovarian cancer, suggesting a possible co-occurrence but not necessarily a direct interaction.",Ovarian cancer,0.0,0.523
MUC16,MUC5B,strong,"MUC16 and MUC5B are both mucins, which are glycoproteins responsible for forming protective mucous barriers on epithelial surfaces. They may interact due to their similar roles in maintaining mucosal integrity and their involvement in protective responses in the gastrointestinal tract and other mucosal surfaces.","Potential involvement in mucosal protection, possibly influencing gastrointestinal diseases or conditions related to mucus production.",0.0,0.867
PI3,SPRR3,weak,"The STRING score is above 0.7, suggesting a potential interaction between PI3 and SPRR3, but the BioGRID score is 0, indicating no significant interaction reported in their database. PubMed abstracts do not provide direct evidence linking the genes, but they are mentioned in the context of diseases involving epithelial and immune responses.",No major disease directly linked to both genes simultaneously found.,0.0,0.765
KLK10,TMPRSS4,weak,"Based on the provided STRING score of 0.266, there is a weak interaction between KLK10 and TMPRSS4.  The BioGRID score of 0 and lack of PubMed abstracts do not support a stronger interaction.",,0.0,0.266
CLDN3,PKP1,weak,"Based on the provided STRING score of 0.232, there is a suggestion of a potential weak interaction. However, the BioGRID score is 0 and there are no PubMed abstracts, indicating a lack of substantial evidence to support a strong interaction.",,0.0,0.232
KRT16,KRT6A,strong,"KRT16 and KRT6A are keratin genes that often co-express in epithelial tissues, particularly in skin. They play a critical role in maintaining the structural integrity of epithelial cells. Mutations or dysregulations in these genes are associated with skin disorders such as Pachyonychia Congenita, which is characterized by nail dystrophy and keratoderma.",Pachyonychia Congenita,0.18898085217110117,0.928
CA9,KRT7,weak,"CA9 and KRT7 are both associated with renal cell carcinoma, but there is limited direct evidence of a functional interaction between them",Clear cell renal cell carcinoma (ccRCC),0.0,0.644
CFTR,SPINK1,weak,"CFTR and SPINK1 are both associated with pancreatic diseases, but direct interaction evidence is limited",Pancreatic diseases,0.0,0.888
CLDN3,SPDEF,weak,"Based on the provided evidence, there is a weak interaction between CLDN3 and SPDEF. The STRING score of 0.287 suggests a weak interaction, while the BioGRID score is 0, indicating no interaction.  The PubMed abstract mentions both genes in the context of lung adenocarcinoma, but does not describe a direct interaction between them.",Lung adenocarcinoma,0.0,0.287
CLDN3,GRHL2,weak,"Based on the provided evidence, the interaction between CLDN3 and GRHL2 is weak.  The STRING score of 0.306 is below the threshold for high confidence, and the BioGRID score is 0. The PubMed abstracts mention both genes in the context of epithelial development and cancer, suggesting a potential indirect or functional relationship, but not a strong direct interaction.",Cancer,0.0,0.306
HNF1B,HNF4A,strong,"HNF1B and HNF4A are both transcription factors involved in the regulation of genes essential for pancreatic beta-cell function and insulin regulation. They are part of a network of genes implicated in maturity-onset diabetes of the young (MODY) and are known to interact at the level of gene regulation, influencing the expression of genes involved in glucose metabolism.",Maturity-onset diabetes of the young (MODY),0.0,0.851
KRT13,KRT23,weak,"Based on the provided evidence, the interaction between KRT13 and KRT23 is weak. The STRING score of 0.459 is below the threshold for high confidence, and the BioGRID score is 0.  The PubMed abstract mentions Barrett's esophagus, suggesting a possible indirect relationship through shared pathways or tissue context, but doesn't directly describe a strong interaction between these two keratin genes.",Barrett's esophagus,0.0,0.459
KRT17,KRT5,strong,"KRT17 and KRT5 are both keratin proteins, which often interact as part of the cytoskeletal structure in epithelial cells. Their interaction is important for the structural integrity and resilience of epithelial tissues.",Intrahepatic cholangiocarcinoma (ICC) and idiopathic pulmonary fibrosis (IPF),0.18898085217110117,0.866
KRT17,KRT19,weak,"Both KRT17 and KRT19 are keratin genes involved in the structural integrity of epithelial cells, but the provided evidence does not strongly support a direct functional interaction between them.",Not specified,0.18898085217110117,0.509
KRT14,KRT19,weak,"Both KRT14 and KRT19 are involved in keratin-related processes and have been mentioned together in studies related to hair follicle stem cells and dermal papilla cells, but direct interaction evidence is limited.","Genodermatoses, Hair follicle disorders",0.124909548940367,0.47
SPRR1B,SPRR3,strong,"Both SPRR1B and SPRR3 are members of the small proline-rich protein family, which are involved in the formation of the cornified cell envelope of keratinocytes. Their high STRING score suggests a strong functional association, possibly in skin barrier formation and response to environmental stress.","Esophageal adenocarcinoma, Dowling-Degos disease",0.0,0.892
DSG3,KRT6A,weak,"Based on the provided evidence, there is weak evidence of interaction between DSG3 and KRT6A. The STRING score is below the high-confidence threshold, and the BioGRID score is 0.  The PubMed abstracts do not provide direct evidence of a functional interaction between these genes.",Lung cancer,0.0,0.68
KRT17,SFN,strong,"KRT17 and SFN are involved in cellular processes related to cancer progression, particularly in epithelial tumors. The high STRING score indicates a strong interaction likely due to their involvement in pathways affecting cell cycle regulation and tumor cell proliferation.",cancer,0.0,0.967
KRT16,KRT6C,strong,"KRT16 and KRT6C are keratin genes involved in the structural integrity and function of epithelial cells. Mutations in these genes have been associated with Pachyonychia congenita, a hereditary disorder characterized by hypertrophic nails and palmoplantar keratoderma. The interaction between these genes contributes to the pathophysiology of the disorder.",Pachyonychia congenita,0.124909548940367,0.502
KRT7,TFF1,weak,"Based on the provided evidence, there is a weak interaction between KRT7 and TFF1. The STRING score is 0.324, which is below the threshold for high confidence. The BioGRID score is 0, indicating no interaction detected.  The PubMed abstracts do not provide direct evidence of a strong interaction.  The abstracts mention Barrett's esophagus and ovarian cancer, but do not describe a direct functional relationship between KRT7 and TFF1 in these contexts. More evidence is needed to determine a stronger interaction.",Barrett's esophagus,0.0,0.324
DSC3,DSG3,strong,"Both DSC3 and DSG3 are desmosomal cadherins, essential for cell-cell adhesion.  The high STRING score (0.934) strongly suggests a direct interaction.  Although the BioGRID score is 0, the PubMed abstracts support their functional relationship in keratinocyte adhesion and differentiation.",,0.0,0.934
CDHR5,USH1C,strong,"CDHR5 and USH1C are involved in the organization of microvilli in epithelial cells. CDHR5 is part of the intermicrovillar adhesion complex (IMAC) that helps in microvilli organization, while USH1C (harmonin) is known to interact with proteins involved in the structure and function of stereocilia and microvilli.","Diseases associated with microvilli dysfunction, such as intestinal disorders or Usher syndrome.",0.0,0.909
KRT15,KRT6B,weak,"Both KRT15 and KRT6B are keratin genes involved in the structural integrity of epithelial cells, but there is limited evidence of direct interaction between them.",Not specified,0.26526816275859066,0.577
DSG3,PKP1,strong,"DSG3 and PKP1 are both critical components of desmosomes, which are responsible for intercellular adhesion in epithelial tissues. DSG3 is a desmosomal cadherin, while PKP1 is a plakophilin that links the cadherins to the intermediate filament cytoskeleton, thereby playing a key role in maintaining the structural integrity and mechanical resilience of tissues.",Lung Squamous Cell Carcinoma (LUSC),0.0,0.951
LCN2,REG1A,weak,"Based on the provided evidence, the STRING score is 0.354, which is below the threshold for high confidence.  The BioGRID score is 0.  The PubMed abstracts mention these genes in the context of inflammatory bowel diseases but do not describe a direct interaction. Therefore, while the genes may be co-expressed or involved in similar pathways related to inflammation, there is insufficient evidence to suggest a strong direct interaction.",Inflammatory Bowel Disease,0.0,0.354
CALML3,GJB1,strong,"CALML3 and GJB1 are likely to have a strong interaction based on a very high STRING score, indicative of a functional or physical interaction. However, no evidence from BioGRID or PubMed abstracts is available to substantiate this interaction further.",Not specifically known for this pair,0.0,0.936
MUC5B,SFTPB,weak,"Based on the provided evidence, there is weak indication of an interaction between MUC5B and SFTPB. The STRING score is below the threshold for high confidence, and the BioGRID score is 0.  The PubMed abstracts mention both genes in the context of lung diseases, but do not directly describe a specific interaction. Therefore, we classify the interaction as weak.",Lung diseases,0.0,0.512
KRT19,KRT6B,weak,"The STRING score is below the high-confidence threshold, and while the BioGRID score is high, the PubMed abstracts do not provide direct evidence of a strong interaction between KRT19 and KRT6B.  The abstracts mention these keratins in the context of different cancers and diseases, suggesting possible co-expression or involvement in similar pathways, but not a direct interaction. Therefore, the interaction is classified as weak.",cancer,0.23239274157331358,0.496
KRT6B,KRT6C,strong,"Both KRT6B and KRT6C are type II keratins that are often co-expressed in stratified squamous epithelia.  The high STRING score (0.772) suggests a strong interaction, potentially reflecting their coordinated expression and function in maintaining the structural integrity of these tissues.  The PubMed abstracts further support this, highlighting their roles in diseases affecting keratin expression such as pachyonychia congenita and head and neck squamous cell carcinomas.",Pachyonychia congenita,0.0,0.772
KRT19,KRT7,strong,"KRT19 and KRT7 are both keratins that are co-expressed in various epithelial tissues and are frequently used as markers in cancer research. They are known to be involved in the structural integrity of epithelial cells and are often studied together in cancer studies due to their co-expression patterns, particularly in tumors. This co-expression is highlighted in cancer organoid studies and proteomic analyses, as indicated by the strong STRING and BioGRID scores.",Cancer,0.124909548940367,0.701
KRT6B,SPRR1B,strong,"KRT6B and SPRR1B are both involved in epithelial biology. The STRING score of 0.741 indicates a high confidence interaction suggesting they may work together in epithelial tissue responses, possibly in conditions like asthma or inflammatory responses.",Asthma,0.0,0.741
AZGP1,SPDEF,weak,"Both AZGP1 and SPDEF were found to be overexpressed in breast carcinoma compared to ovarian carcinoma effusions, suggesting a potential related expression pattern in certain cancer types.",breast carcinoma,0.0,0.233
AKR1B10,CTSE,weak,"Based on the provided STRING score of 0.278, there is a weak interaction between AKR1B10 and CTSE.  The BioGRID score is 0, and the PubMed abstract does not offer direct evidence of a gene-gene interaction.",None identified from provided evidence,0.0,0.278
KRT13,MUC5B,weak,"Based on the provided evidence, there is a weak interaction between KRT13 and MUC5B. The STRING score of 0.325 suggests a weak interaction, while the BioGRID score of 0 indicates no interaction. The PubMed abstract mentions both genes in the context of Barrett's esophagus, suggesting a possible indirect or contextual association, but not necessarily a direct physical or functional interaction.",Barrett's esophagus,0.0,0.325
KRT13,KRT6A,strong,"Both KRT13 and KRT6A are keratin genes, and they are often co-expressed in stratified epithelial tissues.  The high STRING score (0.9) and extremely high BioGRID score (22.73) strongly suggest a direct interaction or co-regulation. Although the provided PubMed abstracts do not directly address their interaction, the high confidence scores from STRING and BioGRID provide compelling evidence of a strong relationship.",,0.23239274157331358,0.9
AGR2,MMP7,weak,"Based on the provided evidence, the STRING score is 0.269, which is below the threshold for high confidence interaction. The BioGRID score is 0, indicating a lack of interaction.  The PubMed abstracts do not directly describe a functional interaction between AGR2 and MMP7. Therefore, the interaction strength is considered weak.",Cancer,0.0,0.269
KRT15,KRT17,weak,"There is limited evidence supporting a strong interaction between KRT15 and KRT17. The STRING score is below the high confidence threshold, and the BioGRID score indicates no known interaction. However, both are keratin genes, which might co-exist or function within similar pathways or structural networks in tissues, especially skin-related.",,0.0,0.618
SERPINB3,SERPINB5,weak,"Both SERPINB3 and SERPINB5 belong to the serpin superfamily, and are serine protease inhibitors.  While the STRING score is below the high confidence threshold, the BioGRID score is exceptionally high. The PubMed abstracts provide context suggesting involvement in similar biological processes (protease-antiprotease balance, inflammation), hinting at a potential interaction. However, without direct evidence of a physical or functional interaction, the strength is classified as weak.",Cancer,0.124909548940367,0.509
AGR2,S100P,weak,"The interaction between AGR2 and S100P is not well-documented in the provided evidence. The STRING score is below the high confidence threshold, and the BioGRID score, while high, does not have a clear percentile context in the provided information. PubMed abstracts do not directly mention an interaction between these two genes.",Not specified,0.18898085217110117,0.613
KRT14,KRT15,weak,"Both KRT14 and KRT15 are keratin genes involved in the structural integrity of epithelial cells, but the provided evidence does not strongly support a direct functional interaction between them.",Not specified,0.0,0.731
DSG3,SPRR1B,weak,"The interaction between DSG3 and SPRR1B is not well-documented in the provided evidence. The STRING score suggests a potential interaction, but the absence of a BioGRID score and the lack of direct evidence in PubMed abstracts indicate that any interaction may be indirect or not yet fully characterized.",Not specified,0.0,0.77
KRT15,KRT19,weak,"Both KRT15 and KRT19 are keratin genes involved in the structural integrity of epithelial cells, but the provided evidence does not strongly support a direct functional interaction between them.",Not specified,0.18898085217110117,0.57
GRHL2,KRT19,weak,"Based on the provided STRING score of 0.32 and a BioGRID score of 0, the interaction between GRHL2 and KRT19 is weak.  Further research is needed to determine the nature and strength of this interaction.",,0.0,0.32
KRT16,KRT5,strong,"KRT16 and KRT5 are both keratin genes that are co-expressed and interact within the keratinocyte cytoskeleton, playing a role in skin integrity and wound healing","Skin diseases, including epidermolysis bullosa simplex and pachyonychia congenita",0.23239274157331358,0.861
GSTA1,UGT1A6,weak,"Both GSTA1 and UGT1A6 are involved in the metabolism of xenobiotics and drugs, but the provided evidence does not strongly support a direct interaction between them.",Not specified,0.0,0.778
KRT5,KRT6A,strong,KRT5 and KRT6A are keratin proteins that often interact as part of the cytoskeletal network in epithelial cells. These interactions are crucial in maintaining the structural integrity and resilience of epithelial tissues. They can also play a role in cellular processes such as wound healing and response to stress.,"No specific major disease directly linked to their interaction, but disruptions in keratin interactions are generally associated with skin disorders and conditions affecting epithelial tissues.",0.124909548940367,0.915
KRT17,KRT6A,strong,"KRT17 and KRT6A are both members of the keratin family, which are structural proteins important for the integrity of epithelial cells. They are known to interact and form heterodimers, contributing to the cytoskeleton of epithelial cells.","Cancer, Skin disorders",0.18898085217110117,0.811
KRT14,KRT6A,strong,"KRT14 and KRT6A are both keratin genes that encode different types of keratin proteins. These proteins are part of the intermediate filament family and play a crucial role in the structural integrity and mechanical resilience of epithelial cells. KRT14 is typically found in the basal layer of the epidermis, while KRT6A is expressed in response to stress or injury, contributing to wound healing and hyperproliferative conditions. The interaction between these genes is indicative of their cooperative roles in maintaining skin and epithelial tissue integrity, especially under stress conditions.",Epidermolysis bullosa and other skin-related disorders,0.124909548940367,0.732
CALML5,S100A14,weak,"The STRING score is 0.335, which is below the threshold for high confidence.  The BioGRID score is unusually high (7.62), requiring further investigation to validate if this is an error or outlier.  Without additional supporting evidence from PubMed abstracts or other reliable sources, the interaction strength is considered weak.",,0.124909548940367,0.335
AGR2,TFF3,strong,"AGR2 and TFF3 are both involved in mucosal protection and repair in the gastrointestinal tract. AGR2 is known to be a protein disulfide isomerase that assists in protein folding, while TFF3 is a trefoil factor involved in mucosal healing. Their interaction is significant in maintaining epithelial integrity and may play a role in inflammatory conditions and cancer.","inflammatory bowel disease, cancer",0.0,0.799
ESRP1,RAB25,weak,"The STRING score suggests a potential interaction, but this is not strongly supported by other evidence.  The BioGRID score is 0, and while PubMed abstracts mention both genes in the context of cancer, they do not describe a direct interaction.",Cancer,0.0,0.795
DSC3,PKP1,strong,"DSC3 and PKP1 are components of desmosomes, playing critical roles in cell-cell adhesion and epithelial integrity",Cancer,0.0,0.894
AGR2,KRT19,weak,"AGR2 and KRT19 may have a potential interaction in the context of cancer, but the evidence is not strong enough to confirm a direct or significant interaction.",Cancer,0.0,0.595
FOXA1,TFF3,weak,"Based on the provided evidence, there is a suggestion of an interaction between FOXA1 and TFF3. The STRING score of 0.714 indicates a potential interaction, but the BioGRID score is 0, suggesting the lack of direct physical interaction evidence.  PubMed abstracts mention both genes in the context of breast cancer research, but do not provide strong evidence of a direct functional interaction between the two genes. Therefore, the interaction strength is considered weak.",Breast Cancer,0.0,0.714
CALML5,SFN,weak,"The interaction between CALML5 and SFN is not well-documented, but they may be involved in epidermal differentiation processes",Not specified,0.124909548940367,0.5
AGR2,FOXA1,strong,"AGR2 and FOXA1 are implicated in breast cancer, including triple-negative breast cancer. There is evidence of interplay between these genes that may influence estrogen receptor status and cancer prognosis.","breast cancer, including triple-negative breast cancer",0.124909548940367,0.85
KRT5,PKP1,strong,"KRT5 and PKP1 are both involved in maintaining the structural integrity of epithelial cells, often studied in the context of skin and lung epithelial tissues. High STRING score suggests a strong interaction, potentially relevant in epithelial-related diseases.",lung cancer,0.0,0.835
KRT13,KRT6C,strong,"KRT13 and KRT6C are both keratins, which are a family of fibrous structural proteins. They often interact within the intermediate filament network of epithelial cells, contributing to the structural integrity and resilience of epithelial tissues.",Diseases related to keratin mutations often include skin disorders such as epidermolysis bullosa simplex and palmoplantar keratoderma.,0.18898085217110117,0.295
HNF4A,SOX2,strong,"HNF4A and SOX2 are transcription factors that may interact to modulate gene expression, particularly in the context of chromatin remodeling. This interaction can influence the accessibility of chromatin to other transcriptional machinery, potentially affecting gene regulation pathways.",,0.0,0.813
KLK11,KRT19,weak,"Based on the provided evidence, there is a weak interaction between KLK11 and KRT19. The STRING score is 0.235, which is below the threshold for high confidence. The BioGRID score is 0, indicating no interaction.  The PubMed abstract mentions KLK11 in the context of cancer but doesn't discuss a direct interaction with KRT19.",Cancer,0.0,0.235
KRT14,PKP1,strong,"KRT14 and PKP1 are involved in the structural integrity of epithelial cells, with PKP1 playing a role in cell-cell adhesion and KRT14 being a key component of the cytoskeleton.","Skin diseases, including epidermolysis bullosa",0.124909548940367,0.777
CA9,SOX2,weak,"Based on the provided evidence, there is a weak suggestion of interaction between CA9 and SOX2. The STRING score is 0.345, below the threshold for high confidence. The BioGRID score is 0, indicating no interaction detected. The PubMed abstracts mention cancer stem cells and related genes, but do not provide direct evidence of a functional relationship between CA9 and SOX2.",Cancer,0.0,0.345
MSLN,PRSS8,weak,"Based on the provided STRING score of 0.322, there is a weak interaction between MSLN and PRSS8.  The BioGRID score of 0 and absence of PubMed abstracts further support this weak interaction.  More evidence is needed to confirm a stronger interaction.",,0.0,0.322
KRT17,MUC16,weak,"Based on the provided evidence, the STRING score is 0.299, suggesting a weak interaction.  The BioGRID score is 0, indicating no interaction. While the PubMed abstract mentions both genes in the context of pancreatic ductal adenocarcinoma, it does not provide direct evidence of a specific interaction between KRT17 and MUC16. Therefore, the interaction is classified as weak.",Pancreatic ductal adenocarcinoma,0.0,0.299
ESRP1,FOXA1,weak,"Based on the provided evidence, the STRING score is 0.264, suggesting a weak interaction.  The BioGRID score is 0, indicating no interaction detected in BioGRID.  The PubMed abstract mentions breast cancer and adriamycin resistance, but doesn't directly describe an interaction between ESRP1 and FOXA1. Therefore, the interaction strength is classified as weak.",Breast Cancer,0.0,0.264
DSG3,KRT5,weak,"DSG3 and KRT5 are both involved in cell adhesion and structural integrity, particularly in epithelial tissues, but direct interaction evidence is limited",Cancer,0.0,0.649
CEACAM5,KRT19,weak,"Co-expression of CEACAM5 and KRT19 mRNA has been observed in circulating tumor cells, suggesting a potential association.  However, the provided evidence does not demonstrate a direct functional interaction.",Pancreatic ductal adenocarcinoma,0.0,0.877
KRT6C,KRT7,weak,"Both KRT6C and KRT7 are keratin genes involved in the structural integrity of epithelial cells, but specific direct interactions between them are not well-documented.",Not specified,0.124909548940367,0.433
MUC13,MUC5B,weak,"Both genes code for mucins, which are heavily involved in the formation of mucus layers in the gastrointestinal tract and other mucosal surfaces.  The provided PubMed abstracts mention mucin overexpression in cancer and the general role of mucins in the gut, but do not describe a direct interaction between MUC13 and MUC5B.  The STRING score suggests a possible interaction, but the BioGRID score is 0, indicating a lack of direct interaction evidence in that database. Therefore, the interaction strength is classified as weak.",Cancer,0.0,0.926
CFTR,CLCA2,strong,"CFTR and CLCA2 are involved in ion transport processes, particularly in epithelial tissues. The STRING score suggests a high-confidence interaction, possibly related to chloride ion channel regulation, which may influence processes such as fluid secretion and absorption in different tissues.",,0.0,0.829
KRT5,KRT6C,strong,"KRT5 and KRT6C are both keratins that are part of the cytoskeletal structure in epithelial cells. They are known to interact as part of the keratin filament network, which provides structural integrity to cells. These interactions are crucial in maintaining the cellular architecture and function of epithelial tissues.",Non-small-cell lung cancer,0.124909548940367,0.723
CLDN2,CLDN3,strong,"Both CLDN2 and CLDN3 are members of the claudin family, which are integral components of tight junctions in epithelial cells. CLDN2 is known for forming paracellular channels in leaky epithelia, while CLDN3 is a barrier-forming claudin. Their co-expression and interaction are crucial in maintaining epithelial barrier functions and ion permeability.",Colorectal cancer,0.0,0.8
KRT17,KRT6C,weak,"Both KRT17 and KRT6C are involved in the pathogenesis of Pachyonychia congenita, a rare hereditary disorder affecting nails and skin, suggesting a possible functional interaction in keratinocyte biology.",Pachyonychia congenita,0.18898085217110117,0.33
KRT14,KRT6C,weak,"KRT14 and KRT6C are both keratin genes involved in the structural integrity of epithelial cells. Their interaction is suggested by their co-expression in certain conditions, but the evidence is not strong enough to confirm a direct or functional interaction.",Squamous cell carcinoma,0.124909548940367,0.554
PKP1,SPRR1B,strong,"PKP1 and SPRR1B are involved in skin-related functions and may interact in processes related to epidermal differentiation and response to skin stress, as indicated by their STRING interaction score.","Skin disorders, potentially influencing conditions like skin cutaneous melanoma.",0.0,0.756
KRT17,SPRR1B,weak,"Based on the provided evidence, there is a weak interaction between KRT17 and SPRR1B. The STRING score of 0.485 is below the high confidence threshold of 0.7, and the BioGRID score is 0.  The PubMed abstract mentions both genes in the context of Oral Lichen Planus and Oral Squamous Cell Carcinoma, suggesting potential co-expression or involvement in similar pathways, but it does not provide direct evidence of a strong interaction.","Oral Lichen Planus, Oral Squamous Cell Carcinoma",0.0,0.485
DSG3,KRT14,strong,"DSG3 (desmoglein 3) and KRT14 (keratin 14) are both critical components in cell adhesion and integrity of epithelial tissues. DSG3 is a part of desmosomes, which are structures that function in strong cell-cell adhesion, and KRT14 is a type I keratin that pairs with type II keratins to form intermediate filaments. Their interaction is crucial in maintaining the structural integrity of epithelial cells, and disruptions in their interaction can lead to skin disorders such as pemphigus vulgaris.",Pemphigus vulgaris,0.0,0.778
KLK10,SERPINB5,weak,"Based on the provided evidence, there is a weak suggestion of an interaction between KLK10 and SERPINB5.  The STRING score of 0.501 is below the threshold for high confidence, and the BioGRID score is 0. The PubMed abstract mentions serine proteases and their inhibitors in relation to gastric cancer, but does not directly address the interaction between KLK10 and SERPINB5.  More evidence is needed to determine a stronger interaction.",Gastric Cancer,0.0,0.501
CEACAM6,LGALS4,weak,"CEACAM6 and LGALS4 are both included in a blood-based test (CELTiC) for colorectal cancer, suggesting a potential association. However, the STRING and BioGRID scores do not indicate a direct interaction.  The PubMed abstracts mention their co-occurrence in a diagnostic context, but don't describe a direct functional interaction.",Colorectal Cancer,0.0,0.193
CEACAM5,CEACAM6,strong,"CEACAM5 and CEACAM6 are both members of the carcinoembryonic antigen (CEA) family, often involved in cell adhesion and signaling. They are frequently co-expressed and have been observed to interact in processes related to cancer progression, particularly in colorectal and other epithelial cancers. Their interaction may influence cellular adhesion, migration, and immune evasion mechanisms in cancerous cells.","Cancer, particularly colorectal and epithelial cancers",0.124909548940367,0.71
KRT6A,KRT6C,strong,"KRT6A and KRT6C are both keratin genes and are part of the type II keratin family, which are known to form intermediate filaments in epithelial cells. Their interaction is crucial in the structural integrity and function of epithelial tissues.",Pachyonychia congenita,0.124909548940367,0.71
KRT6A,SPRR1B,strong,KRT6A and SPRR1B are involved in skin differentiation and function. The high STRING score indicates a strong interaction potentially related to keratinocyte differentiation or response to epidermal injury.,,0.0,0.882
AZGP1,KLK3,strong,"AZGP1 and KLK3 are involved in prostate cancer, with KLK3 (also known as PSA) being a well-known biomarker for the disease. The high STRING and BioGRID scores suggest a significant interaction, possibly related to their roles in prostate cancer progression and biomarker potential.",Prostate cancer,0.124909548940367,0.833
CALML5,GJB1,strong,"The high STRING score suggests a strong functional or physical association between CALML5 and GJB1, although BioGRID does not provide any additional evidence for this interaction.",,0.0,0.935
KLK10,KLK11,weak,"KLK10 and KLK11 are both members of the kallikrein-related peptidase family, which are involved in various physiological and pathological processes, including cancer. The high STRING score suggests a potential functional association, but the lack of BioGRID score and non-specific PubMed abstracts limit the evidence strength.",Cancer,0.0,0.825
KRT15,KRT6A,weak,"Both KRT15 and KRT6A are keratin genes involved in the structural integrity of epithelial cells, but the provided evidence does not strongly support a direct functional interaction between them.",Not specified,0.31389040111146815,0.766
KLK11,KRT16,weak,"Based on the provided STRING score of 0.269, there is a weak interaction between KLK11 and KRT16.  The BioGRID score of 0 and absence of PubMed abstracts do not suggest a strong interaction.",,0.0,0.269
KRT13,KRT5,weak,"Both KRT13 and KRT5 are keratin genes involved in the structural integrity of epithelial cells, but the provided evidence does not strongly support a direct functional interaction between them.",Not specified,0.124909548940367,0.483
KRT19,MSLN,weak,"Based on the provided evidence, there is a weak interaction between KRT19 and MSLN. The STRING score is 0.43, which is below the threshold for high confidence. The BioGRID score is 0, indicating no interaction.  The PubMed abstract mentions both genes in the context of pancreatic ductal adenocarcinoma, suggesting possible co-expression or association, but not necessarily a direct interaction.",Pancreatic Ductal Adenocarcinoma,0.0,0.43
KLK11,SPINK1,weak,"Based on the provided evidence, there is a weak suggestion of an interaction between KLK11 and SPINK1.  The STRING score of 0.312 is below the threshold for high confidence, and the BioGRID score is 0. The PubMed abstract mentions serine proteases and their inhibitors in relation to gastric cancer, but does not directly address the interaction between KLK11 and SPINK1.  More evidence is needed to confirm a stronger interaction.",Gastric Cancer,0.0,0.312
KRT19,MUC5B,weak,"Based on the provided STRING score of 0.276, which is below the high confidence threshold, and a BioGRID score of 0, the interaction between KRT19 and MUC5B is considered weak.  The PubMed abstract does not provide direct evidence of interaction.",,0.0,0.276
FOXA1,HNF4A,strong,"FOXA1 and HNF4A are both transcription factors that play critical roles in liver function and development. They often cooperate in regulating gene expression in hepatocytes, with FOXA1 acting as a pioneer factor facilitating the binding of HNF4A to chromatin.","Liver-related diseases, possibly including liver cancer due to dysregulation of liver-specific transcription networks.",0.0,0.833
REG1A,SPINK1,weak,"Based on the provided STRING score of 0.385 and BioGRID score of 0, the interaction between REG1A and SPINK1 is weak.  The PubMed abstract mentions both genes in the context of ulcerative colitis, suggesting a potential indirect or shared pathway association, but not a direct interaction.  Further research is needed to confirm a stronger interaction.",Ulcerative Colitis,0.0,0.385
CALML5,SOX2,weak,"Based on the provided STRING score of 0.236, there is a weak suggestion of interaction.  However, the BioGRID score is 0 and there are no PubMed abstracts, indicating a lack of substantial supporting evidence for a strong interaction.",,0.0,0.236
KLK10,MUC16,weak,"Based on the provided evidence, there is a weak suggestion of an interaction between KLK10 and MUC16. The STRING score of 0.239 is below the threshold for high confidence, and the BioGRID score is 0.  The PubMed abstracts mention both genes in the context of cancer, but do not describe a direct interaction. Therefore, more evidence is needed to confirm a stronger interaction.",Cancer,0.0,0.239
DSC3,KRT5,weak,"DSC3 and KRT5 are both involved in cell adhesion and epithelial structure, but direct interaction evidence is limited",Breast Cancer,0.0,0.706
SPDEF,TFF1,weak,"Based on the provided evidence, there is a weak interaction between SPDEF and TFF1. The STRING score is 0.52, below the threshold for high confidence. The BioGRID score is 0, indicating no interaction. While the PubMed abstracts mention these genes in the context of cancer research, they do not provide direct evidence of a strong interaction between them.",Cancer,0.0,0.52
KLK10,PRSS8,weak,"Based on the provided STRING score of 0.257 and a BioGRID score of 0, the interaction between KLK10 and PRSS8 is considered weak.  The PubMed abstract mentions serine proteases in relation to gastric cancer, but doesn't directly address the interaction between KLK10 and PRSS8.  More evidence is needed to confirm a stronger interaction.",Gastric Cancer,0.0,0.257
KRT14,KRT5,strong,"KRT14 and KRT5 are both keratin proteins that form a heterodimer complex crucial for the structural integrity of the basal cells in the epidermis. Mutations in these genes are associated with epidermolysis bullosa simplex, a condition characterized by skin fragility and blistering.",Epidermolysis bullosa simplex,0.18898085217110117,0.999
PI3,SPRR1B,weak,"The interaction between PI3 and SPRR1B is suggested by a high STRING score, but lacks supporting evidence from BioGRID and PubMed abstracts, which do not directly mention an interaction between these genes.",Not specified,0.0,0.787
ANXA8,KRT19,weak,"Based on the provided evidence, there is a weak interaction between ANXA8 and KRT19. The STRING score is 0.207, which is below the threshold for high confidence. The BioGRID score is 0, indicating no interaction.  The PubMed abstract mentions both genes in the context of oral squamous cell carcinoma, but does not describe a direct interaction between them.",oral squamous cell carcinoma,0.0,0.207
CFTR,MUC5B,weak,"CFTR dysfunction in cystic fibrosis leads to altered mucus properties, including increased MUC5B accumulation.  The evidence suggests a relationship, but the STRING and BioGRID scores do not indicate a strong direct interaction.",Cystic Fibrosis,0.0,0.582
CEACAM5,KRT5,strong,"CEACAM5 and KRT5 are implicated in respiratory diseases and certain lung cancers. They may co-express or interact in the context of epithelial tissue pathology, particularly in the small airway epithelium, which is involved in diseases like COPD, IPF, and lung cancer.","chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), lung cancer",0.0,0.753
COL17A1,KRT5,weak,"COL17A1 and KRT5 are involved in the structural integrity of the skin, particularly in the context of epidermolysis bullosa, where mutations in these genes can lead to skin fragility.",Epidermolysis bullosa,0.0,0.799
COL17A1,MMP7,weak,"Based on the provided STRING score of 0.221 and BioGRID score of 0, the interaction between COL17A1 and MMP7 is weak.  The PubMed abstracts do not offer direct evidence of a strong interaction. Further investigation is needed to confirm the nature and strength of this interaction.","Idiopathic pulmonary fibrosis (IPF) and Non-small cell lung cancer (NSCLC) are mentioned in the abstracts, but without direct evidence of a gene-gene interaction in these diseases.",0.0,0.221
MUC13,MUC16,weak,"Both MUC13 and MUC16 are mucins involved in various functions at mucosal surfaces and are implicated in cancers, but direct interaction evidence is limited",Cancer,0.0,0.911
A2ML1,KLK6,strong,"A2ML1 and KLK6 are involved in protease inhibition and extracellular matrix remodeling, potentially contributing to tumor progression.",Cancer,0.0,0.77
A2ML1,KLK7,strong,"The STRING database indicates a high confidence interaction between A2ML1 and KLK7 with a score of 0.835, suggesting a potential biological interaction. However, no supporting evidence from BioGRID or PubMed abstracts is available.",,0.0,0.835
ABCC8,SLC30A8,weak,"Both genes are involved in insulin secretion and pancreatic beta cell function, but direct interaction evidence is limited",Diabetes,0.0,0.726
ACSM2A,ACSM2B,strong,"ACSM2A and ACSM2B are both involved in fatty acid metabolism and share similar functions related to acyl-CoA synthetase activity. They participate in the activation of medium-chain fatty acids by converting them into their respective acyl-CoA derivatives, which is essential for subsequent metabolic processes.",Potential implications in metabolic disorders due to their role in fatty acid metabolism.,0.124909548940367,0.999
ACSM2B,IYD,weak,"Based on the provided STRING score of 0.286, there is a weak interaction between ACSM2B and IYD.  The BioGRID score of 0 and the absence of PubMed abstracts do not provide additional support for a stronger interaction.",,0.0,0.286
ACTC1,PAX7,weak,"Based on the provided evidence, there is a weak interaction between ACTC1 and PAX7.  The STRING score is low (0.23), and the BioGRID score is 0. The PubMed abstract mentions skeletal muscle stem and progenitor cells, which are relevant to both genes' functions, but does not describe a direct interaction.",,0.0,0.23
ACTC1,TBX5,weak,"Based on the provided evidence, the STRING score is below the high-confidence threshold (0.611 < 0.7), and the BioGRID score is 0.  The PubMed abstracts mention congenital heart disease, in which both genes play a role, but do not describe a direct interaction. Therefore, the interaction strength is considered weak.",Congenital Heart Disease,0.0,0.611
ALB,APOA2,strong,High STRING and BioGRID scores suggest a strong interaction between ALB and APOA2.  Further research is needed to fully elucidate the nature of this interaction based on the provided abstracts which don't directly address it.,Not specified in provided abstracts,0.124909548940367,0.962
ALB,ORM1,strong,"ALB and ORM1 are both involved in liver function and inflammatory responses. ALB is the most abundant plasma protein and maintains oncotic pressure and serves as a carrier protein for various substances. ORM1, also known as alpha-1-acid glycoprotein, is an acute-phase plasma protein that modulates the immune system. The high STRING score suggests a potential functional interaction, possibly in the context of inflammatory responses or liver-related diseases.",Liver-related diseases,0.0,0.998
ALB,PCSK9,weak,"PCSK9 is associated with inflammation in the vascular system and plays a role in hepatic inflammation, but direct interaction with ALB is not well-documented","Cardiovascular diseases, Hepatic inflammation",0.0,0.72
ALB,SAA1,weak,"Limited evidence suggests a potential interaction between ALB and SAA1, possibly related to inflammatory processes and amyloidosis, but the interaction is not well-characterized.","Amyloidosis, Inflammatory diseases",0.0,0.705
ALB,SERPINA3,strong,"ALB and SERPINA3 are both involved in the progression of diabetic nephropathy. ALB is a major protein in blood plasma and its levels are often altered in kidney diseases. SERPINA3, a serine protease inhibitor, has been implicated in immune response regulation and inflammation, both of which are key elements in diabetic nephropathy. Their interaction potentially affects disease progression by modulating immune responses and inflammation in the kidneys.",Diabetic nephropathy,0.0,0.914
ALB,SERPINA6,strong,"ALB (albumin) and SERPINA6 (corticosteroid-binding globulin) are both involved in transport and regulation of steroid hormones in the bloodstream. ALB is known to bind various hormones, including corticosteroids, while SERPINA6 specifically binds cortisol. Their interaction is significant in maintaining hormone homeostasis, particularly during stress and inflammatory responses.",cachexia,0.0,0.885
ALDOB,SLC2A2,weak,"The STRING score suggests a potential interaction, but the lack of a BioGRID score and limited information from PubMed abstracts prevent a definitive conclusion.  The PubMed abstract mentions disorders related to monosaccharide metabolism (ALDOB is involved in fructose metabolism), and SLC2A2 is a glucose transporter, suggesting a possible indirect interaction through metabolic pathways. However, this is not strong evidence of a direct interaction.",Congenital monosaccharide-disaccharide metabolism disorders,0.0,0.802
APCS,C4BPA,weak,"APCS and C4BPA may interact in the context of immune response and complement system regulation, but specific mechanisms are not well-documented.",Hepatocellular carcinoma (HCC),0.18898085217110117,0.711
APOA2,ORM1,strong,"APOA2 and ORM1 are involved in lipid metabolism and inflammatory response, both of which are relevant to coronary heart disease and stroke. The interaction between these genes is supported by a high STRING score, indicating strong functional association, potentially through pathways influencing cardiovascular outcomes.",Coronary heart disease,0.0,0.772
APOA2,SAA1,strong,APOA2 and SAA1 interact during the acute-phase response where serum amyloid A (SAA) associates with high-density lipoproteins (HDL) that contain APOA2. This interaction is significant as it can influence lipid metabolism and is implicated in conditions like reactive AA amyloidosis.,reactive AA amyloidosis,0.124909548940367,0.799
APOA4,APOA5,strong,"APOA4 and APOA5 are both involved in lipid metabolism and are located in the same gene cluster. They have a functional relationship in the regulation of plasma triglyceride levels. Though the BioGRID score is low, the high STRING score indicates a strong interaction between these genes, likely due to their joint role in lipid regulation.",Familial Chylomicronemia Syndrome,0.0,0.918
APOA4,SERPINA1,weak,"Limited evidence suggests a potential interaction between APOA4 and SERPINA1, possibly related to lipid metabolism and inflammatory processes, but the exact nature of their interaction is not well-characterized.","Preeclampsia, Stroke risk, Obsessive-Compulsive Disorder",0.0,0.793
APOD,SERPIND1,weak,"Based on the provided STRING score of 0.247, there is a weak interaction between APOD and SERPIND1.  The BioGRID score is 0, and no PubMed abstracts are available, further supporting a weak interaction.",,0.0,0.247
ASCL1,DLL3,weak,"ASCL1 and DLL3 are involved in neuroendocrine differentiation and have been implicated in small cell lung cancer (SCLC), but direct interaction evidence is limited",Small cell lung cancer,0.0,0.681
B3GNT3,MUC4,weak,"Based on the provided evidence, there is limited information to support a strong interaction between B3GNT3 and MUC4. The STRING score of 0.546 is below the threshold for high confidence, and the BioGRID score is 0.  The PubMed abstract mentions glycosylation's role in pancreatic cancer, which involves both genes, but doesn't directly confirm a specific interaction. Therefore, the interaction is classified as weak.",Pancreatic Cancer,0.0,0.546
BARX1,HAND2,weak,"BARX1 and HAND2 are involved in jaw development and evolution, but direct interaction evidence is limited",Congenital bony syngnathia,0.0,0.569
BCAN,MMP10,weak,"The interaction between BCAN and MMP10 is not well-documented, but given the STRING score and BioGRID score, there might be some level of interaction, though not strongly supported by current evidence.",Not specified,0.124909548940367,0.613
BCAN,MMP13,weak,"BCAN may interact with MMP13, but the evidence is not strong enough to confirm a significant interaction",Not specified,0.124909548940367,0.626
BCAN,MMP3,weak,"BCAN may interact with MMP3, but the evidence is not strong enough to confirm a significant interaction",Not specified,0.124909548940367,0.677
BCAS1,FAM83E,weak,"Based on the STRING score of 0.278, there is a weak interaction between BCAS1 and FAM83E.  The BioGRID score is 0, and there are no PubMed abstracts, which further supports a weak interaction or lack of strong evidence for an interaction.",,0.0,0.278
C8A,CR2,weak,"Both genes are involved in the complement system, but the provided evidence does not show a direct interaction.  The PubMed abstracts mention complement system components in the context of disease, suggesting potential indirect relationships or shared pathways.",inflammatory diseases,0.0,0.0
CA10,NEFM,weak,"Based on the provided STRING score of 0.288, there is a weak interaction between CA10 and NEFM.  The BioGRID score is 0, and no PubMed abstracts were found, further supporting a weak interaction or lack of strong evidence for a direct interaction.",,0.0,0.288
CALB1,GAD1,strong,"CALB1 (Calbindin 1) and GAD1 (Glutamate Decarboxylase 1) are both involved in the regulation of neurotransmitter processes. CALB1 is known for its role in buffering intracellular calcium levels, while GAD1 is responsible for the synthesis of the inhibitory neurotransmitter GABA. Their interaction is important in the regulation of synaptic transmission and maintaining proper neural function.",Tinnitus,0.0,0.873
CALB1,MAPT,weak,"The interaction between CALB1 and MAPT is not well-documented in the provided evidence. The STRING score is below the high confidence threshold, and the BioGRID score, while numerically high, does not directly indicate a strong interaction without context. PubMed abstracts mention diseases related to these genes but do not describe a direct interaction.",Neurodegenerative disorders,0.124909548940367,0.386
CCK,QRFPR,weak,,clear cell renal cell carcinoma,0.0,0.271
CCK,SCTR,weak,"CCK (Cholecystokinin) is a peptide hormone that plays a key role in digestion and appetite regulation, while SCTR (Secretin receptor) is involved in the regulation of water homeostasis and bicarbonate secretion. The interaction between these genes may be related to digestive processes, but the evidence is not strong.",Digestive disorders,0.0,0.261
CDH10,CDH18,weak,"CDH10 and CDH18 are both cadherin family members involved in cell adhesion, but specific interaction evidence is limited",Not specified,0.0,0.767
CDH10,NRXN1,weak,"DNA variants in CDH10 and NRXN1 may be associated with neurodevelopmental processes and predispose to completed suicide, suggesting a potential indirect interaction.","Neurodevelopmental disorders, Suicide",0.0,0.671
CDH17,KRT20,weak,"Both CDH17 and KRT20 are associated with intestinal metaplasia and gastric carcinogenesis, but direct interaction evidence is limited",Gastric cancer,0.0,0.463
CDX2,MUC6,weak,"CDX2 and MUC6 are involved in gastrointestinal differentiation and mucin production, respectively, but direct interaction evidence is limited",Gastrointestinal and endometrial cancers,0.0,0.772
CELF3,NEFM,weak,"Based on the provided evidence, there is a weak interaction between CELF3 and NEFM. The STRING score is 0.251 which is below the high confidence threshold of >0.7. The BioGRID score is 0, indicating no interaction found in BioGRID. There are no PubMed abstracts to support an interaction.",,0.0,0.251
CHGA,KRT20,weak,"The interaction between CHGA and KRT20 is not well-documented in the provided evidence. The STRING score suggests a potential interaction, but the absence of a BioGRID score and the unrelated PubMed abstract indicate limited supporting evidence.",Not specified,0.0,0.776
CHGA,NPY,strong,"CHGA and NPY are both involved in the regulation of neuroendocrine signals, and play roles in the storage and secretion of neuropeptides. CHGA is a precursor for several bioactive peptides that regulate neuroendocrine secretion, while NPY is a neurotransmitter that influences food intake and energy homeostasis.",Metabolic disorders,0.0,0.744
KLK2,SERPINA3,strong,"KLK2, a kallikrein-related peptidase, interacts with SERPINA3, an alpha-1-antichymotrypsin, to form a complex that inhibits the proteolytic activity of KLK2. This interaction is important in regulating protease activity in physiological conditions, particularly in the context of the prostate.",Prostate cancer,0.124909548940367,0.851
KLK2,SERPINA5,strong,"KLK2 (Kallikrein-Related Peptidase 2) is known to be inhibited by SERPINA5 (Serpin Family A Member 5), which acts as a serine protease inhibitor. This interaction is crucial in the regulation of proteolytic activity, particularly in physiological processes involving tissue remodeling and cancer progression.",prostate cancer,0.124909548940367,0.866
KLK6,KLK7,weak,"KLK6 and KLK7 are part of the Kallikrein-related peptidases family, which are involved in various physiological and pathological processes, including tumor microenvironment regulation. However, direct interaction evidence is limited.","Cancer, Alzheimer's disease",0.0,0.669
KLK6,KLK8,weak,"Both KLK6 and KLK8 are part of the kallikrein-related peptidases family and are serine proteases. They are implicated in neurodegenerative processes; however, direct interaction evidence between them is lacking.","Neurodegenerative diseases, potentially Alzheimer's disease",0.0,0.566
KLK7,KLK8,weak,"KLK7 and KLK8 are both kallikrein-related peptidases involved in various biological processes, including cancer progression and possibly Alzheimer's disease, but direct interaction evidence is limited","Cancer, Alzheimer's disease",0.0,0.805
KNG1,SERPINA1,strong,"KNG1 and SERPINA1 are involved in blood coagulation pathways. KNG1 encodes kininogen, which is involved in the kinin-kallikrein system, a key regulator of inflammation and blood pressure. SERPINA1 encodes alpha-1-antitrypsin, an inhibitor of proteases that can affect inflammatory processes. The STRING score indicates a strong interaction, potentially impacting conditions like venous thromboembolism, as suggested by GWAS studies.",Venous thromboembolism,0.0,0.943
KRT1,LRRC26,weak,"Based on a STRING score of 0.726, there is a weak suggestion of interaction.  However, the lack of supporting evidence from BioGRID and PubMed abstracts weakens the confidence in a strong interaction.",,0.0,0.726
KRT20,KRT4,weak,"Based on the provided evidence, there is limited support for a direct interaction between KRT20 and KRT4. The STRING score is low (0.191), and the BioGRID score is 0.  The PubMed abstract mentions both genes in the context of Barrett's esophagus, suggesting they may be co-expressed or involved in related pathways within this context. However, this is not definitive evidence of a direct interaction. Further research is needed to confirm the nature of this relationship.",Barrett's esophagus,0.0,0.191
KRT20,KRT8,weak,"KRT20 and KRT8 are both keratin genes involved in the structural integrity of epithelial cells, but the provided evidence does not strongly support a direct functional interaction between them.","Barrett's esophagus, Merkel cell carcinoma",0.18898085217110117,0.409
KRT20,MUC2,weak,"KRT20 and MUC2 are both involved in the maintenance and function of epithelial tissues, with KRT20 being a marker of differentiated epithelial cells and MUC2 playing a role in mucus production. Their interaction may be related to epithelial barrier function and differentiation processes.","Barrett's esophagus, Intestinal diseases",0.0,0.811
KRT20,REG4,weak,"Both KRT20 and REG4 are involved in intestinal metaplasia and gastric carcinogenesis, but direct interaction evidence is limited",Gastric cancer,0.0,0.68
KRT8,MMP1,weak,"Based on the provided evidence, there is a weak interaction between KRT8 and MMP1. The STRING score of 0.202 suggests a low confidence interaction.  The BioGRID score is 0, indicating no interaction.  The provided PubMed abstract does not directly address the interaction between these two genes. More evidence is needed to confidently determine a strong interaction.",Breast Cancer,0.0,0.202
LCE1A,LCE1F,strong,"LCE1A and LCE1F are members of the late cornified envelope (LCE) gene family, which are involved in skin barrier function and are co-expressed in epidermal differentiation.",Psoriasis,0.124909548940367,0.958
LCE1A,LCE2D,strong,"LCE1A and LCE2D are involved in the formation of the cornified cell envelope, which is crucial for skin barrier function. They are part of the late cornified envelope (LCE) gene cluster, which is implicated in skin diseases such as psoriasis.",psoriasis,0.124909548940367,0.999
LCE1A,LCE6A,strong,"Both LCE1A and LCE6A are members of the late cornified envelope (LCE) gene family, which are involved in skin barrier function. The high STRING score suggests a strong functional association, possibly in skin barrier formation or maintenance.",Psoriasis,0.0,0.978
LCE1F,LCE2D,strong,"LCE1F and LCE2D are part of the late cornified envelope (LCE) gene cluster, involved in skin barrier function and implicated in psoriasis",Psoriasis,0.124909548940367,0.918
LCE1F,LCE6A,strong,"Both LCE1F and LCE6A are members of the late cornified envelope (LCE) gene family, which are involved in skin barrier function and are associated with psoriasis.",Psoriasis,0.0,0.875
LCE2D,LCE6A,strong,"LCE2D and LCE6A are part of the late cornified envelope (LCE) gene cluster, which plays a crucial role in the skin barrier function. The high STRING score suggests a significant interaction between these genes, possibly contributing to skin homeostasis and related diseases.",Head and neck squamous cell carcinoma (HNSCC),0.0,0.999
LGI1,ZIC4,weak,"The interaction between LGI1 and ZIC4 is not well-documented in the provided evidence. While the STRING score suggests a potential interaction, the absence of a BioGRID score and the lack of direct mention in PubMed abstracts indicate limited evidence.","Autoimmune encephalitis, Paraneoplastic neurologic syndromes",0.0,0.79
LTF,SFTPA2,strong,"LTF and SFTPA2 are both involved in immune response and lung function. LTF is known for its antimicrobial properties, while SFTPA2 plays a critical role in lung surfactant activity and immune defense in the lungs. The STRING score suggests a potential interaction, although it is not corroborated by BioGRID or specific PubMed articles.","lung-related diseases, respiratory infections",0.0,0.725
LTF,SLPI,weak,"LTF and SLPI are both involved in immune responses and may interact in the context of antimicrobial activity and immunomodulation, but direct evidence of interaction is limited","Infectious diseases, ARDS, Cancer",0.0,0.811
MAGEC1,MAGEC3,weak,"The STRING score of 0.405 suggests a potential interaction, but it's below the high-confidence threshold.  The BioGRID score is 0, and the PubMed abstract does not provide direct evidence of interaction. Therefore, the interaction is considered weak.",Colon Cancer,0.0,0.405
MAPT,NEFM,weak,"The interaction between MAPT and NEFM is not well-documented in the provided evidence. The STRING score suggests a possible association, but the absence of a BioGRID score and the lack of direct mention in PubMed abstracts indicate limited evidence for a strong interaction.",Neurodegenerative disorders,0.0,0.738
MAPT,NLGN1,weak,"Based on the provided evidence, there is a weak suggestion of an interaction between MAPT and NLGN1.  The STRING score is 0.304, which is below the threshold for high confidence. The BioGRID score is 0, indicating no interaction detected.  The PubMed abstract mentions both genes in the context of neurological disorders (Alzheimer's disease and autism spectrum disorder), suggesting a possible indirect or shared pathway relationship, but not a direct interaction. More evidence is needed to definitively characterize the interaction.",Neurological disorders (Alzheimer's disease and autism spectrum disorder),0.0,0.304
GPX2,GSTA1,weak,"GPX2 and GSTA1 are both involved in oxidative stress response and detoxification processes, but direct interaction evidence is limited",Nonalcoholic fatty liver disease (NAFLD),0.0,0.838
GRIA4,SHISA9,strong,"GRIA4 and SHISA9 are involved in synaptic transmission and modulation. GRIA4 is an AMPA receptor subunit, and SHISA9 is known to modulate AMPA receptor activity, which is crucial for synaptic plasticity and transmission efficiency.",,0.0,0.919
HABP2,NR1H4,weak,"Based on the provided STRING score of 0.247, there is a suggestion of a weak interaction.  However, the BioGRID score is 0 and there are no PubMed abstracts, indicating a lack of substantial supporting evidence for a strong interaction.",,0.0,0.247
HAND2,HOXA11,weak,"Based on the provided evidence, there is limited support for a direct interaction between HAND2 and HOXA11.  The STRING score of 0.394 is below the threshold for high confidence, and the BioGRID score is 0.  The PubMed abstracts do not provide direct evidence of a functional interaction between the two genes. While both genes are involved in development, the abstracts do not indicate a shared pathway or mechanism. Therefore, the interaction strength is classified as weak.",None identified from the given evidence,0.0,0.394
HAND2,HOXD13,weak,"Based on the provided evidence, there is weak support for an interaction between HAND2 and HOXD13.  The STRING score of 0.695 is below the threshold for high confidence, and while the BioGRID score is high, it's unclear whether this score specifically represents a direct interaction or an indirect association. The PubMed abstracts don't directly describe a functional interaction between these genes. More evidence is needed to confirm a strong interaction.",Synpolydactyly,0.18898085217110117,0.695
HAND2,SERPINB7,weak,"Based on the STRING score of 0.244, there is a weak interaction. The BioGRID score is 0 and there are no PubMed abstracts to support a stronger interaction.",,0.0,0.244
HAO1,NOX1,weak,"Based on the STRING score of 0.236, there is a weak interaction between HAO1 and NOX1.  The BioGRID score of 0 and lack of PubMed abstracts do not provide additional support for a stronger interaction.",,0.0,0.236
HOXA11,PGR,weak,"HOXA11 and PGR may be involved in female reproductive tract development and endometriosis, but direct interaction evidence is limited",Endometriosis,0.0,0.467
HOXB5,HOXB6,strong,HOXB5 and HOXB6 are part of the Homeobox B gene cluster and are involved in the regulation of developmental processes. Their co-expression and functional similarities suggest a strong interaction potential in developmental gene regulatory networks.,,0.0,0.982
HOXC10,PITX1,weak,"Based on the provided evidence, there is weak support for an interaction between HOXC10 and PITX1.  The STRING score is below the high confidence threshold (0.414 < 0.7), and the BioGRID score is 0. The PubMed abstracts mention the genes in the context of limb development but do not describe a direct interaction.",none,0.0,0.414
HP,LTF,weak,"The interaction between HP and LTF is suggested by a high STRING score, but lacks supporting evidence from BioGRID and PubMed abstracts which do not directly mention their interaction.",Not specified,0.0,0.811
IHH,MMP13,weak,"IHH (Indian Hedgehog) and MMP13 (Matrix Metallopeptidase 13) are involved in endochondral ossification, a critical process in skeletal development. IHH signaling may influence the expression of MMP13, which is involved in the degradation of extracellular matrix components during cartilage development and bone growth.",Osteoarthritis,0.0,0.688
IL8,WNT2,weak,"Based on the provided PubMed abstracts, IL8 and WNT2 are both expressed in gastric cancer and their expression levels are associated with the prognosis of the disease. However, there is no direct evidence of a strong interaction between these two genes from the STRING or BioGRID scores or the abstracts.  The abstracts suggest a potential correlation in expression in a specific context (gastric cancer), but not necessarily a direct interaction.",Gastric Cancer,0.0,0.0
INSM1,PTPRN,strong,"The STRING database indicates a strong interaction between INSM1 and PTPRN with a score of 0.917, suggesting a high confidence interaction. However, no direct experimental data or literature support from BioGRID or PubMed were found to further elaborate on the biological nature of this interaction.",,0.0,0.917
INSM1,SOX8,weak,"Based on the provided evidence, the STRING score suggests a potential interaction, but it's not strong (0.272). The BioGRID score is 0, indicating no interaction detected in that database.  The PubMed abstract mentions gene expression in the context of placode development, but doesn't directly describe an interaction between INSM1 and SOX8. Therefore, the interaction strength is considered weak.",Not specified in the provided evidence,0.0,0.272
ITGB6,MMP12,weak,"ITGB6 encodes an integrin, alpha v beta 6, which is involved in epithelial tissue repair and has been linked to lung tissue remodeling. MMP12 is a matrix metalloproteinase involved in the breakdown of extracellular matrix, often associated with inflammation and tissue remodeling. The interaction is suggested in the context of lung diseases such as COPD, where both genes may contribute to tissue remodeling and disease progression.",Chronic Obstructive Pulmonary Disease (COPD),0.0,0.714
ITGB6,S100A7,strong,"The interaction between ITGB6 and S100A7 is indicated to be strong based on the STRING score, which is above the 0.7 high confidence threshold. ITGB6, an integrin, may interact with S100A7, a protein involved in immune response and inflammation, suggesting a role in cellular adhesion and signaling processes.",,0.0,0.78
IVL,KLK7,strong,"IVL and KLK7 are both involved in skin barrier function. IVL, or involucrin, is a component of the epidermal differentiation complex and is essential for the formation of the cornified envelope in skin cells. KLK7 is a serine protease that is involved in the desquamation process by degrading corneodesmosomes. An imbalance in KLK7 activity can lead to skin disorders such as atopic dermatitis, where impaired barrier function is a key feature. The interaction between IVL and KLK7 is significant in maintaining skin integrity and function.",Skin disorders such as atopic dermatitis and psoriasis.,0.0,0.702
IVL,S100A7,weak,"Both IVL and S100A7 are involved in epidermal differentiation and are part of the epidermal differentiation complex (EDC), suggesting a potential functional relationship in skin differentiation processes.",Psoriasis,0.0,0.616
IVL,SERPINB13,weak,"Based on the provided STRING score of 0.293, there is a weak interaction between IVL and SERPINB13.  The BioGRID score is 0, and there are no PubMed abstracts to support a stronger interaction.  Further research is needed to confirm this interaction.",,0.0,0.293
IVL,SPRR1A,strong,"IVL and SPRR1A are both involved in skin barrier formation and are co-expressed in keratinocytes, suggesting a functional interaction in skin differentiation and possibly in skin cancer progression.",Skin cutaneous melanoma (SKCM),0.0,0.963
IVL,SPRR2A,strong,IVL and SPRR2A are involved in the formation of the cornified envelope in epidermal differentiation. Their interaction is crucial for the structural integrity and barrier function of the skin.,,0.0,0.776
KIF5A,SEZ6L,weak,"Based on the provided STRING score of 0.256, there is a weak interaction between KIF5A and SEZ6L.  The BioGRID score of 0 and lack of PubMed abstracts further support a weak interaction or lack of known direct interaction.",,0.0,0.256
CYP4A11,CYP4F8,weak,"Both CYP4A11 and CYP4F8 are involved in the NADPH-dependent oxygenation of prostaglandin H(2) and its analogues, suggesting a potential functional interaction in the metabolism of these compounds",Not specified,0.0,0.916
DCX,TUBB2B,strong,"DCX and TUBB2B are involved in neuronal migration and cortical development, with DCX encoding a microtubule-associated protein and TUBB2B being a beta-tubulin isotype. Their interaction is crucial for proper brain development.",Malformations of cortical development,0.0,0.95
DEFB105A,DEFB106A,weak,"Both genes are part of the defensin beta family, which are involved in immune response, but specific interaction mechanisms between DEFB105A and DEFB106A are not well-documented.",Not specified,0.0,0.903
DEFB105A,DEFB108B,strong,"DEFB105A and DEFB108B likely interact as part of the defensin family, which are involved in immune response and possess antimicrobial properties. The very high STRING score suggests a strong functional association.",,0.0,0.903
DEFB105A,DEFB110,weak,"The interaction between DEFB105A and DEFB110 is suggested by a high STRING score, indicating potential functional association, but lacks supporting evidence from BioGRID or PubMed literature.",Not specified,0.0,0.794
DEFB106A,DEFB108B,strong,"DEFB106A and DEFB108B are both members of the beta-defensin family, which is involved in the immune response to pathogens. The high STRING score suggests a strong functional association likely related to their roles in host defense mechanisms.",Infections and immune system-related disorders,0.0,0.799
DEFB108B,DEFB114,weak,"The STRING score is slightly above the threshold for high confidence, suggesting a potential interaction, but there is no support from BioGRID or specific evidence in PubMed abstracts. The interaction might involve a role in immune response, given the context of respiratory infections.",,0.0,0.706
DEFB108B,DEFB116,weak,"Both genes are part of the defensin beta family, which are involved in immune response, but direct interaction evidence is limited",Infectious diseases,0.0,0.748
DEFB108B,DEFB121,weak,"The interaction between DEFB108B and DEFB121 is suggested by a high STRING score, but lacks supporting evidence from BioGRID and PubMed abstracts",Not specified,0.0,0.786
DEFB110,DEFB112,strong,"The STRING score of 0.76 indicates a high confidence of interaction, suggesting a possible functional or physical association between DEFB110 and DEFB112. However, no additional supportive evidence from BioGRID or specific PubMed abstracts is available to further characterize this interaction.",No specific major disease associated with the interaction between DEFB110 and DEFB112 is identified.,0.0,0.76
DEFB110,DEFB113,weak,"DEFB110 and DEFB113 are both members of the beta-defensin family, which are involved in immune response. The high STRING score suggests potential functional association, but lack of BioGRID score and PubMed abstracts limits the evidence.",Immune-related diseases,0.0,0.878
DEFB110,DEFB114,weak,"DEFB110 and DEFB114 are both members of the beta-defensin family, which are involved in immune responses, but direct interaction evidence is limited",Immune-related diseases,0.0,0.799
DEFB110,DEFB115,weak,"Both genes are part of the defensin beta family, which are involved in immune response, but specific interaction between DEFB110 and DEFB115 is not well-documented",Immune-related diseases,0.0,0.788
DEFB110,DEFB121,weak,"DEFB110 and DEFB121 are both members of the defensin beta family, which are involved in immune response. The STRING score suggests a possible functional association, but the lack of BioGRID score and PubMed abstracts indicates limited evidence for direct interaction.",Immune-related diseases,0.0,0.763
DEFB110,DEFB128,strong,"Both DEFB110 and DEFB128 are beta-defensins, a family of antimicrobial peptides involved in the immune response and inflammation. They may function together in maintaining mucosal immunity and defense against pathogens.",Infections and inflammatory diseases,0.0,0.766
DEFB112,DEFB116,weak,"DEFB112 and DEFB116 are both members of the defensin beta gene family, which are involved in immune response. The STRING score suggests a possible functional association, but the lack of BioGRID score and PubMed abstracts limits the evidence.",Immune-related diseases,0.0,0.719
DEFB112,DEFB121,weak,"The interaction between DEFB112 and DEFB121 is suggested by a high STRING score, but lacks supporting evidence from BioGRID and PubMed abstracts.",Not specified,0.0,0.734
DEFB113,DEFB115,weak,"DEFB113 and DEFB115 are both members of the beta-defensin family, which are involved in immune responses. The STRING score suggests a potential interaction, but the lack of BioGRID score and PubMed abstracts limits the confidence in this interaction.",Immune-related diseases,0.0,0.742
DEFB113,DEFB121,strong,"DEFB113 and DEFB121 are both part of the defensin family of antimicrobial peptides, which play a key role in the immune response by disrupting the membranes of pathogens. Their interaction is likely due to their shared biological function and co-regulation in antimicrobial activities.",,0.0,0.818
DEFB113,DEFB128,weak,"Both DEFB113 and DEFB128 are involved in the innate immune response, particularly in the epithelial barrier function, but direct interaction evidence is limited","Infectious diseases, Inflammatory conditions",0.0,0.779
DEFB114,DEFB115,weak,"DEFB114 and DEFB115 are both members of the beta-defensin family, which are involved in immune response. The STRING score suggests a potential interaction, but the lack of BioGRID score and PubMed abstracts limits the evidence.",Immune-related diseases,0.0,0.738
DEFB114,DEFB116,weak,"Both DEFB114 and DEFB116 are members of the beta-defensin family, which are involved in immune responses, but direct interaction evidence is limited",Infectious diseases,0.0,0.761
DEFB114,DEFB128,weak,"The high STRING score suggests a potential interaction between DEFB114 and DEFB128, but the lack of BioGRID score and PubMed abstracts limits the confidence in this interaction.",Not specified,0.0,0.806
DEFB115,DEFB116,strong,"DEFB115 and DEFB116 are both beta-defensin genes, which are part of the innate immune system. Given their similar functions and high STRING score, it is likely they interact or co-express to participate in antimicrobial activity. However, no specific interaction details are available in BioGRID or PubMed.",,0.0,0.816
DEFB115,DEFB121,strong,"DEFB115 and DEFB121 are both members of the beta-defensin family, which are involved in immune response and antimicrobial activity. The high STRING score suggests a strong functional association, possibly in immune system processes.","Infectious diseases, Immune system disorders",0.0,0.812
DEFB115,DEFB128,strong,"DEFB115 and DEFB128 are both part of the beta-defensin family, which are antimicrobial peptides involved in the innate immune response. The STRING score indicates a high-confidence interaction, suggesting a functional link possibly related to their antimicrobial activities.",,0.0,0.731
DEFB116,DEFB121,strong,"DEFB116 and DEFB121 both belong to the beta-defensin family, which are antimicrobial peptides involved in the innate immune response. Given the high STRING score, these genes are likely to interact in pathways related to immune defense mechanisms.",Infectious diseases,0.0,0.761
DEFB116,DEFB128,weak,"DEFB116 and DEFB128 are both members of the beta-defensin family, which are involved in immune response and antimicrobial activity. The STRING score suggests a potential interaction, but the lack of BioGRID score and PubMed abstracts limits the evidence.",Immune-related diseases,0.0,0.784
DES,DLK1,weak,"Based on the provided evidence, the STRING score is 0.216, which is below the threshold for high confidence interaction.  The BioGRID score is 0, indicating no interaction found in BioGRID.  The PubMed abstracts do not provide direct evidence of a strong interaction between DES and DLK1. Therefore, the interaction strength is classified as weak.",No major disease is directly indicated in the provided evidence.,0.0,0.216
DES,MUC4,weak,"Based on the provided PubMed abstracts, there's a weak suggestion of an association between DES (Dry Eye Syndrome) and MUC4 (mucin gene).  One abstract mentions evaluating MUC4 mRNA levels in patients with DES. However, this does not directly demonstrate a gene-gene interaction, only a potential correlation in expression levels in a disease context. The STRING and BioGRID scores support the lack of a direct interaction.",Dry Eye Syndrome,0.0,0.0
DES,UGT1A9,weak,"Based on the provided abstracts, UGT1A9 is involved in the metabolism of various compounds, including xenobiotics.  One abstract mentions that DES (diethylstilbestrol), an estrogen, can inhibit UDP-glucuronosyltransferases (UGTs), a family of enzymes including UGT1A9. This suggests a potential indirect interaction where DES might affect the activity of UGT1A9. However, the STRING and BioGRID scores are low, indicating a lack of direct physical interaction. Therefore, the interaction strength is classified as weak.",,0.0,0.0
DIRAS2,STMN2,weak,"Based on the provided STRING score of 0.258, there is a suggestion of a weak interaction between DIRAS2 and STMN2.  However, the BioGRID score is 0 and there are no PubMed abstracts, indicating a lack of strong supporting evidence for a direct interaction.",,0.0,0.258
DKK1,SFRP1,weak,"Both DKK1 and SFRP1 are involved in the Wnt signaling pathway, but direct interaction evidence is limited","Cancer, Bone diseases",0.0,0.883
DLK1,NPY,weak,"DLK1 and NPY may have roles in adipocyte proliferation and differentiation, but direct interaction evidence is limited",Obesity,0.0,0.227
DUOX2,IYD,strong,"DUOX2 and IYD are involved in thyroid hormone biosynthesis, with DUOX2 playing a role in hydrogen peroxide generation necessary for thyroid hormone synthesis and IYD being involved in iodide recycling, crucial for the same process",Congenital hypothyroidism,0.0,0.93
EHF,ELF3,weak,"Based on the provided evidence, the interaction between EHF and ELF3 is weak. The STRING score (0.524) is below the threshold for high confidence, and while the BioGRID score is high (4.6249095489403675), it's unusual and requires further investigation to confirm if it is reliable. The PubMed abstracts do not provide direct evidence of a functional interaction between these two genes.",Cancer,0.124909548940367,0.524
ELF3,SPRR2A,strong,"ELF3, a member of the ETS transcription factor family, is known to regulate epithelial-specific genes such as SPRR2A. The high STRING score indicates strong co-expression or functional interaction between these genes, likely in epithelial cell differentiation or stress response.",None specified,0.0,0.818
EMX2,EMX2OS,weak,"EMX2OS is a long non-coding RNA transcribed from the opposite strand of EMX2, potentially involved in transcriptional regulation",Wilms' tumour,0.0,0.0
EPB42,HBM,strong,"The interaction between EPB42 and HBM is suggested by the high STRING score, indicating a potential functional or physical association. EPB42 is involved in maintaining erythrocyte membrane stability, while HBM is part of the hemoglobin complex. Their interaction may influence erythrocyte structure and function.",,0.0,0.843
EPCAM,KRT20,weak,"EPCAM and KRT20 are co-expressed in circulating tumor cells (CTCs) and are used as markers for detecting these cells, indicating a potential interaction in the context of cancer metastasis.",Cancer,0.0,0.622
EPCAM,KRT8,strong,"EPCAM and KRT8 are known to interact in epithelial tissues. EPCAM (Epithelial Cell Adhesion Molecule) is involved in cell adhesion, while KRT8 (Keratin 8) is a type II cytokeratin involved in the structural integrity of epithelial cells. Their interaction is crucial for maintaining epithelial cell structure and function.","Cancer, particularly epithelial-origin cancers such as colon and lung cancer.",0.0,0.845
EPCAM,PROM1,strong,"EPCAM and PROM1 are both involved in hepatocellular carcinoma (HCC) and epithelial-mesenchymal transition (EMT), suggesting a potential interaction in cancer progression and prognosis",Hepatocellular carcinoma,0.0,0.864
ERBB4,PTPRT,weak,"The interaction between ERBB4 and PTPRT is not well-documented in the literature, and the provided evidence does not strongly support a functional interaction",Not specified,0.124909548940367,0.441
FGB,HP,strong,"FGB (Fibrinogen beta chain) and HP (Haptoglobin) may interact in the context of inflammation and wound healing processes, given their roles in acute phase response and blood coagulation.","Inflammatory diseases, cardiovascular diseases",0.124909548940367,0.751
FOXA2,PCK1,weak,"FOXA2 is a transcription factor that may regulate the expression of PCK1, a key enzyme in gluconeogenesis, suggesting a potential regulatory relationship in metabolic processes",Metabolic disorders,0.0,0.336
FOXA2,SFTPC,weak,"FOXA2 is involved in the regulation of lung development and differentiation, including the expression of SFTPC in alveolar type II cells, but direct interaction evidence is limited",Lung diseases,0.0,0.427
FOXE1,IYD,weak,"FOXE1 and IYD are both associated with thyroid function and congenital hypothyroidism, but direct interaction evidence is limited",Congenital hypothyroidism,0.0,0.708
FSHB,TSHB,weak,"FSHB and TSHB are both subunits of pituitary glycoprotein hormones, specifically follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH) respectively. While they do not directly interact with each other, they are both involved in the endocrine regulation by the pituitary gland. The STRING score suggests a potential indirect or weak interaction through shared pathways or regulatory mechanisms in hormone production and secretion.",,0.0,0.71
GABRA1,GABRA5,weak,"Both GABRA1 and GABRA5 are subunits of the GABA-A receptor, suggesting a potential interaction.  However, the provided evidence only shows a STRING score above the threshold and lacks supporting evidence from BioGRID or direct interaction details from PubMed abstracts. The abstracts mention GABA receptors in relation to neurological disorders, but don't describe a specific interaction between GABRA1 and GABRA5.",neurological disorders,0.0,0.749
GABRA1,GABRG1,strong,"GABRA1 and GABRG1 are both subunits of the GABA-A receptor, which is a pentameric ion channel. These subunits interact to form functional GABA-A receptors, which mediate inhibitory neurotransmission in the central nervous system.",Epilepsy,0.0,0.811
GABRA1,GAD1,weak,"GABRA1 is a subunit of the GABA-A receptor, which is involved in inhibitory neurotransmission, while GAD1 is responsible for the synthesis of GABA, the primary inhibitory neurotransmitter. Their interaction is indirect, through the GABAergic system.",Neurological disorders,0.0,0.774
GABRA5,GABRG1,weak,"Both GABRA5 and GABRG1 are subunits of GABA receptors, suggesting a potential interaction.  However, the STRING score is only slightly above the threshold for high confidence, and the BioGRID score is 0. The PubMed abstracts do not provide direct evidence of a strong interaction.",,0.0,0.766
GABRB3,SLC1A2,weak,"Based on the provided evidence, there is a weak interaction between GABRB3 and SLC1A2.  The STRING score of 0.311 suggests a weak interaction, while the BioGRID score of 0 indicates no interaction. The PubMed abstract mentions both genes in the context of epileptic encephalopathies, suggesting a potential indirect or functional relationship. However, there's insufficient evidence to claim a strong direct interaction.",Epileptic Encephalopathies,0.0,0.311
GAP43,MAG,weak,"GAP43 is involved in neurite outgrowth and regeneration, while MAG is a myelin-associated glycoprotein that inhibits nerve regeneration. No direct interaction is indicated, but they both play roles in nerve growth and regeneration processes, possibly affecting similar pathways or biological processes.",Peripheral nerve injury,0.0,0.695
GAP43,NCAM1,strong,"GAP43 and NCAM1 are both involved in neuronal growth and synaptic plasticity. The high STRING score indicates a significant interaction, potentially involving neurodevelopmental and neurodegenerative processes.","Alzheimer's disease, Schizophrenia",0.0,0.831
GCNT3,MUC6,weak,"GCNT3 and MUC6 are involved in the synthesis and modification of mucins, which are key components of the mucus layer in the gastrointestinal tract. Their interaction is suggested by their roles in mucin production and modification, but direct evidence of a physical or regulatory interaction is lacking.",Gastrointestinal diseases,0.0,0.553
GC,REG4,weak,"Based on the provided abstracts, REG4 is highly upregulated in gastric cancer (GC).  However, the STRING and BioGRID scores are 0, indicating a lack of direct interaction evidence. The abstracts mention GC and REG4 in the context of gastric cancer, suggesting a potential association, but not necessarily a direct gene-gene interaction. Therefore, the interaction strength is considered weak.",Gastric Cancer,0.0,0.0
GGT6,GSTM1,weak,"The interaction between GGT6 and GSTM1 is suggested by a high STRING score, but lacks supporting evidence from BioGRID or PubMed literature.",Not specified,0.0,0.797
GJB2,GJB4,weak,"Both GJB2 and GJB4 are connexin genes involved in gap junction formation, with potential roles in hearing impairment and other conditions, but direct interaction evidence is limited",Hearing impairment,0.0,0.75
CHI3L1,SPP1,weak,"Limited evidence suggests potential interaction in contexts like inflammatory diseases and cancer, but no direct interaction is strongly supported by current data.","Ulcerative colitis, Glioblastoma, Cardiovascular diseases",0.0,0.69
CHRNA2,CHRNA4,strong,"CHRNA2 and CHRNA4 are both involved in the formation of nicotinic acetylcholine receptors, which are important for synaptic transmission in the nervous system. Mutations in these genes are implicated in autosomal dominant sleep-related hypermotor epilepsy, particularly nocturnal frontal lobe epilepsy.",Autosomal dominant sleep-related hypermotor epilepsy,0.0,0.939
CHRNA4,KCNQ2,weak,"Based on the provided evidence, there's a weak indication of interaction between CHRNA4 and KCNQ2.  The STRING score of 0.924 suggests a potential interaction, but the absence of a BioGRID score and the lack of direct evidence in the provided PubMed abstracts limit the confidence in assessing a strong interaction. The PubMed abstracts mention epilepsy and genetic disorders, which are areas where both genes may play a role, but this is not direct evidence of a functional interaction.",Epilepsy,0.0,0.924
CLDN4,EPCAM,weak,"CLDN4 and EPCAM may interact in the context of tight junction formation and epithelial cell adhesion, but direct evidence is limited",Cancer,0.0,0.785
CLDN4,KRT8,weak,No direct interaction described in the provided evidence; potential indirect association through cellular processes like injury-repair and development,Not specified,0.0,0.622
COL11A1,IHH,weak,"Based on the provided STRING score of 0.316 and a BioGRID score of 0, along with PubMed abstracts that don't directly describe an interaction, the interaction strength between COL11A1 and IHH is considered weak.  Further research is needed to confirm a stronger interaction.",None identified from the provided evidence,0.0,0.316
COL11A1,MMP13,weak,"Based on the provided evidence, the STRING score of 0.609 suggests a possible interaction, but it is below the threshold for high confidence.  The BioGRID score of 0 indicates no interaction found in that database. The PubMed abstracts do not provide direct evidence of a strong interaction between COL11A1 and MMP13.",No major disease identified from the provided evidence,0.0,0.609
COL1A1,COL7A1,strong,"COL1A1 and COL7A1 are both collagen genes that play roles in maintaining the structure and integrity of connective tissues and skin. Their interaction is likely involved in the structural formation and repair of tissues, particularly skin, where collagens are crucial components for strength and resilience.","Skin disorders, connective tissue disorders",0.124909548940367,0.79
COL1A1,DPT,weak,"COL1A1 and DPT are involved in extracellular matrix (ECM) remodeling, but direct interaction evidence is limited","Cancer, particularly in the context of dysfunctional adipose tissue and breast cancer",0.0,0.429
COL1A1,SPP1,weak,"COL1A1 and SPP1 may interact in the extracellular matrix, but evidence is limited","Osteoporosis, Cancer",0.0,0.747
COMP,MMP13,weak,"Based on the provided evidence, there is a weak interaction between COMP and MMP13. The STRING score is below the high confidence threshold (0.641 < 0.7), and the BioGRID score is 0, indicating a lack of direct interaction evidence in BioGRID.  The PubMed abstracts do not offer strong support for a direct interaction between these genes.",Osteoarthritis,0.0,0.641
COMP,MMP3,weak,"Based on the provided evidence, the STRING score is below the high-confidence threshold (0.629 < 0.7), and the BioGRID score is 0.  The PubMed abstracts do not reveal direct interaction evidence between COMP and MMP3. Therefore, although some relation may exist due to their roles in cartilage metabolism, the interaction strength is classified as weak.",Osteoarthritis,0.0,0.629
CP,FOXE1,weak,"Germline variants in FOXE1 are associated with cleft palate (CP).  The provided PubMed abstracts suggest an association, but the STRING and BioGRID scores are low, indicating weak evidence of a direct interaction.  More research is needed to confirm a direct interaction.",Cleft Palate,0.0,0.0
CP,HP,strong,"The interaction between CP (Ceruloplasmin) and HP (Haptoglobin) is implicated in the acute phase response, a part of the body's reaction to inflammation. Both proteins are acute phase reactants and play significant roles in modulating the body's response to stress and infection. Their interaction supports regulation of iron metabolism and oxidative stress, which are critical in inflammatory conditions.",Inflammatory disorders,0.124909548940367,0.947
CP,LTF,strong,"CP and LTF are involved in protective and regenerative roles in the lung, with evidence suggesting a significant interaction based on high STRING and BioGRID scores.","Acute respiratory distress syndrome (ARDS), Cerebral palsy",0.124909548940367,0.971
CRYM,CUX2,weak,"Based on a STRING score of 0.282 and a BioGRID score of 0, the interaction between CRYM and CUX2 is weak.  Further research is needed to confirm a stronger interaction.",,0.0,0.282
CSH2,PRLR,strong,"CSH2 (Chorionic Somatomammotropin Hormone 2) interacts with PRLR (Prolactin Receptor) to mediate prolactin-like activities, including mammary gland development and lactation",Reproductive disorders,0.0,0.964
CT45A1,MAGEB2,weak,"Based on the provided STRING score of 0.351, which is below the high confidence threshold of >0.7, and a BioGRID score of 0, there is weak evidence to support a direct interaction between CT45A1 and MAGEB2.  The PubMed abstract mentions CT antigens in general but doesn't describe a specific interaction between these two genes. More evidence is needed to confirm a stronger interaction.",Cancer,0.0,0.351
CT47A10,CT47A9,strong,"CT47A10 and CT47A9 are members of the CT47 gene family, known for their high sequence similarity and potential roles in cancer. The high STRING score suggests a strong functional association, possibly through co-expression or shared pathways.",Cancer,0.0,0.999
CT47A2,CT47A9,strong,"CT47A2 and CT47A9 are part of the same gene family, suggesting a potential interaction or shared functionality, especially given the high STRING score indicating predicted functional interaction.",,0.0,0.999
CUX2,INSM1,weak,"The STRING score suggests a potential interaction, but it's below the high-confidence threshold.  The BioGRID score is 0, and the PubMed abstracts don't provide direct evidence of a strong interaction. Therefore, the interaction strength is classified as weak.",None identified from provided evidence,0.0,0.286
MIOX,UGT1A8,strong,"The high STRING score suggests a strong predicted functional interaction, possibly involving metabolic pathways or detoxification processes.",No major disease directly linked to this gene interaction is identified.,0.0,0.901
MMP10,MMP13,weak,"Both MMP10 and MMP13 are matrix metalloproteinases involved in the degradation of extracellular matrix components, but specific direct interactions between them are not well-documented.","Tissue remodeling diseases, Cancer",0.09449042608555058,0.66
MMP10,MMP3,strong,"MMP10 and MMP3 are both members of the matrix metalloproteinase (MMP) family, which are involved in the breakdown of extracellular matrix components. These two metalloproteinases often work together or in parallel pathways to facilitate tissue remodeling and repair, as well as playing roles in pathological processes such as cancer metastasis and inflammatory responses.",cancer,0.23239274157331358,0.973
MMP13,MMP3,weak,"Both MMP13 and MMP3 are matrix metalloproteinases involved in tissue remodeling and degradation of extracellular matrix components, but the provided evidence does not strongly support a direct interaction between them.","Osteoarthritis, Inflammatory bowel disease, Chronic renal failure",0.0,0.557
MMP1,MMP12,weak,"Both MMP1 and MMP12 are involved in extracellular matrix degradation, but direct interaction evidence is limited",Cancer,0.09449042608555058,0.625
MMP3,SERPINA3,weak,"Based on the provided evidence, there is a weak suggestion of an interaction between MMP3 and SERPINA3.  The STRING score of 0.232 is below the high-confidence threshold. The BioGRID score is 0, indicating no interaction detected in that database. While PubMed abstracts mention both genes separately in the context of disease (glaucoma and cancer), there is no direct evidence of a functional or physical interaction between them.",Multiple,0.0,0.232
MUC6,PSCA,strong,"MUC6 and PSCA are linked through their roles in gastric cancer. The STRING score indicates a high confidence interaction, suggesting a potential pathway or co-regulation in gastric cancer pathogenesis.",Gastric cancer,0.0,0.732
MYBPC1,TNNT1,weak,"The interaction between MYBPC1 and TNNT1 is suggested by a high STRING score, but lacks supporting evidence from BioGRID and PubMed abstracts, indicating potential but unconfirmed functional association.",Rotator cuff tendinopathy,0.0,0.729
NEUROG1,UNCX,weak,"Based on the provided evidence, there is a weak interaction between NEUROG1 and UNCX.  The STRING score of 0.315 is below the high confidence threshold. The BioGRID score is 0. The PubMed abstract mentions UNCX's expression in neurally-fated cells, which is relevant to NEUROG1's role in neurogenesis, suggesting a potential indirect or weak interaction. However, without stronger evidence, the interaction strength is classified as weak.",,0.0,0.315
NMS,NPS,weak,"The interaction between NMS and NPS is suggested by a high STRING score, but lacks supporting evidence from BioGRID and PubMed literature.",Not specified,0.0,0.738
OR1S1,OR1S2,weak,"OR1S1 and OR1S2 are both olfactory receptors, which may have similar functions in odor detection, but no specific interaction mechanism is documented",None specifically associated with this interaction,0.0,0.787
OR5K3,OR5K4,weak,"OR5K3 and OR5K4 are both olfactory receptor genes, which may have similar functions in odor detection, but no specific interaction mechanism is documented",,0.0,0.782
OR8B4,OR8B8,strong,"Both OR8B4 and OR8B8 are members of the olfactory receptor family, which are G-protein-coupled receptors involved in odorant signal transduction. High STRING score indicates a strong functional association between these genes, likely due to their similar roles in olfactory signal pathways.",No major disease association is directly linked with the interaction of these genes.,0.0,0.999
ORM1,SAA1,weak,"ORM1 and SAA1 are both involved in acute phase response, but direct interaction evidence is limited",Inflammatory diseases,0.0,0.717
ORM1,SERPINA3,strong,"ORM1 and SERPINA3 are both involved in acute phase response and inflammation, with potential interactions in immune response pathways","Inflammatory diseases, COVID-19",0.124909548940367,0.918
PDZK1IP1,SLC5A1,weak,"The high STRING score suggests a potential interaction between PDZK1IP1 and SLC5A1, but the lack of BioGRID score and PubMed abstracts indicates limited experimental evidence.",Not specified,0.0,0.927
PGR,ROS1,weak,"Based on the provided STRING score of 0.285, there is a weak interaction between PGR and ROS1.  The BioGRID score is 0, and there are no PubMed abstracts, indicating a lack of substantial evidence for a strong interaction.",,0.0,0.285
PIK3C2G,PLCZ1,weak,"The interaction between PIK3C2G and PLCZ1 is suggested by a high STRING score, but lacks supporting evidence from BioGRID and PubMed literature.",Not specified,0.0,0.719
PITX1,TP63,weak,"Limited evidence suggests a potential interaction between PITX1 and TP63, possibly related to gene-expression patterns in head and neck carcinomas.",Head and neck carcinomas,0.124909548940367,0.63
PLP1,PMP2,weak,"The STRING score is below the high confidence threshold, and the BioGRID score is 0.  The provided PubMed abstract discusses myelination generally but does not directly address the interaction between PLP1 and PMP2. Therefore, while both genes are involved in myelination, there is not strong evidence of a direct interaction.",Hypomyelination,0.0,0.596
PPP1R14C,PPP1R14D,strong,"PPP1R14C and PPP1R14D are both inhibitors of protein phosphatase 1 (PP1), suggesting a functional interaction in regulating PP1 activity. The high STRING score indicates a potentially strong interaction despite the lack of BioGRID score.",,0.0,0.924
PRM1,PRM2,strong,"PRM1 and PRM2 both encode protamines, which are sperm-specific nuclear proteins that replace histones during spermatogenesis and are essential for sperm chromatin condensation and stabilization.",male infertility,0.0,0.987
PRM1,SMCP,weak,"Based on the provided PubMed abstracts, both PRM1 and SMCP are involved in spermatogenesis and mRNA regulation in post-meiotic spermatogonia.  However, the STRING and BioGRID scores are low, indicating a lack of strong direct interaction evidence. The abstracts suggest a potential co-regulation or functional relationship in spermatogenesis, but not necessarily a direct physical interaction.",infertility,0.0,0.466
PRM1,TNP1,strong,PRM1 and TNP1 are both involved in the chromatin reorganization and condensation process during sperm development. Protamines (PRMs) and transition nuclear proteins (TNPs) are key classes of sperm nuclear basic proteins that regulate these processes in the spermatozoon head.,Infertility,0.0,0.961
PRM2,TNP1,strong,"PRM2 and TNP1 are critical in sperm chromatin reorganization and condensation. PRM2 (protamine 2) and TNP1 (transition nuclear protein 1) function sequentially in the process of replacing histones and remodeling the chromatin structure during sperm development, leading to the highly compacted form of DNA required for proper sperm function.",Infertility,0.0,0.966
PRR20A,PRR20C,strong,"PRR20A and PRR20C exhibit a high-confidence interaction based on STRING and BioGRID scores, suggesting a strong functional relationship",Not specified,0.124909548940367,0.999
PRR20A,PRR20D,strong,"PRR20A and PRR20D exhibit a high-confidence interaction based on STRING and BioGRID scores, suggesting a strong functional relationship",Not specified,0.124909548940367,0.999
PRR20C,PRR20D,strong,"PRR20C and PRR20D exhibit a high-confidence interaction based on STRING and BioGRID scores, suggesting a strong functional relationship",Not specified,0.124909548940367,0.999
S100A7,SERPINB13,weak,"The STRING score is below the high confidence threshold, and there is no BioGRID score. No strong interaction is indicated by the current evidence. Both genes are mentioned in studies related to skin diseases such as psoriasis, but no direct interaction is detailed.",Psoriasis,0.0,0.558
S100A7,SERPINB4,weak,"S100A7 and SERPINB4 are both involved in skin diseases and immune responses, but direct interaction evidence is limited","Psoriasis, Skin Cancer",0.124909548940367,0.705
S100A7,SLPI,weak,"Based on the provided evidence, there is weak evidence to suggest an interaction between S100A7 and SLPI. The STRING score of 0.442 is below the threshold for high confidence, and the BioGRID score is 0.  The PubMed abstracts mention both genes in the context of immune response and epithelial function, suggesting a potential indirect or functional relationship, but not a direct physical interaction.",,0.0,0.442
SERPINA6,TM4SF5,weak,"Based on a STRING score of 0.234 and a BioGRID score of 0, the interaction between SERPINA6 and TM4SF5 is weak.  Additional evidence is needed to confirm a stronger interaction.",,0.0,0.234
SFTPA2,SFTPC,strong,"Both SFTPA2 and SFTPC are involved in pulmonary surfactant metabolism and have been implicated in respiratory diseases, including interstitial lung disease and pulmonary fibrosis.","Interstitial lung disease, Pulmonary fibrosis",0.0,0.993
SLC22A11,SLC5A12,weak,No known direct interaction between SLC22A11 and SLC5A12 based on the provided evidence,Not specified,0.0,0.751
SLCO1B1,UGT1A8,weak,"SLCO1B1 and UGT1A8 are both involved in drug metabolism pathways. SLCO1B1 is known for its role in the hepatic uptake of various drugs, while UGT1A8 is involved in the glucuronidation process, which is a major phase II metabolic pathway. Their interaction might influence the pharmacokinetics of drugs like mycophenolic acid, although direct evidence of interaction is not strong.",,0.0,0.799
SPRR1A,SPRR2A,strong,"SPRR1A and SPRR2A are both part of the small proline-rich proteins family, which play a critical role in the formation of the cornified cell envelope in epithelial tissues. They are involved in the protective barrier function of the skin and other epithelia.",Esophageal squamous cell carcinoma,0.0,0.891
SPRR1A,SPRR2E,weak,"The STRING score suggests a potential interaction, however, the lack of supporting evidence from BioGRID and the limited relevance of PubMed abstracts result in a weak interaction classification.",oral squamous cell carcinoma,0.0,0.858
SPRR2A,SPRR2E,strong,"SPRR2A and SPRR2E are part of the small proline-rich proteins family, which are involved in the formation of the cornified cell envelope in epithelial cells. Their interaction is critical in skin barrier formation and function.",Psoriasis,0.0,0.962
TM4SF5,TSPAN1,strong,"TM4SF5 and TSPAN1 are both members of the tetraspanin family, which is involved in various cellular processes including signaling, cell adhesion, and migration. The STRING score of 0.806 suggests a strong interaction, likely due to shared functional pathways or involvement in similar cellular processes. However, there is currently no direct evidence from BioGRID or PubMed abstracts.",Cancer,0.0,0.806
MMD2,NCAN,weak,"Based on the provided STRING score of 0.331, there is a suggestion of a weak interaction.  However, the BioGRID score is 0 and there are no PubMed abstracts, indicating a lack of substantial evidence for a strong interaction.",,0.0,0.331
MT3,TTR,weak,"TTR and MT3 are involved in amyloid-beta (Aβ) metabolism, with TTR acting as an Aβ scavenger protein and MT3 being a low molecular weight metal-binding protein. Their interaction may influence Aβ aggregation and deposition, relevant in Alzheimer's disease.",Alzheimer's disease,0.26526816275859066,0.413
MUC15,MUC17,weak,"Both MUC15 and MUC17 are involved in the composition and function of the mucus barrier, but direct interaction evidence is limited",Ulcerative colitis,0.0,0.932
MYF5,MYOD1,weak,"Based on the provided evidence, the STRING score of 0.667 suggests a possible interaction, but it does not reach the high-confidence threshold (>0.7).  The BioGRID score is 0, indicating no interaction found in that database. The PubMed abstracts do not provide direct evidence of a functional interaction between MYF5 and MYOD1. Therefore, the interaction strength is classified as weak.",none,0.0,0.667
MYOD1,TBPL2,strong,"MYOD1 is a key regulator of muscle differentiation and TBPL2, a transcription factor, may interact with MYOD1 to influence gene expression during muscle development. The high STRING score indicates a strong predicted functional association.",,0.0,0.931
MYOD1,VGLL2,weak,"MYOD1 is a well-known myogenic regulatory factor that plays a role in muscle differentiation, while VGLL2 is associated with transcriptional regulation in muscle development. Although there is no strong direct interaction, they are both involved in muscle-related pathways.","muscle development disorders, rhabdomyosarcoma",0.0,0.717
NAPSA,PAX8,weak,"Limited evidence suggests a potential interaction in the context of endometrial serous carcinoma, but the biological relevance is not well-established.",Endometrial serous carcinoma,0.0,0.72
OLIG2,SOX1,weak,"Limited evidence suggests potential interaction in the context of cell proliferation and differentiation, but specific mechanisms are not well-documented",Not specified,0.0,0.64
OLIG2,TF,weak,Potential cooperation in gene regulation in oligodendrocytes as suggested by transcription factor involvement.,Brain Disorders,0.0,0.0
POSTN,SERPINB2,strong,"Both POSTN and SERPINB2 are involved in Type-2 inflammatory processes, which are relevant in diseases such as asthma and chronic rhinosinusitis with nasal polyps.",Asthma,0.0,0.853
POU3F2,SIM1,weak,"Based on the provided STRING score of 0.707, there is a suggestion of an interaction.  However, the BioGRID score is 0, and the PubMed abstracts do not provide direct evidence of a functional interaction between POU3F2 and SIM1. The abstracts discuss their roles in related biological processes (hypothalamic function and developmental delay), but not a direct interaction.",None identified from provided evidence,0.0,0.707
RBP4,TTR,strong,"RBP4 is the plasma carrier of retinol and forms a complex with TTR (transthyretin), which is crucial for the transport of retinol in the blood. This interaction is significant in the context of retinoid metabolism and associated diseases.","transthyretin amyloidosis (ATTR), cardiometabolic disease",0.26526816275859066,0.999
SCGB1A1,SCGB3A2,strong,"SCGB1A1 and SCGB3A2 are both secretoglobins that are structurally similar and may play roles in respiratory functions and diseases, such as idiopathic pulmonary fibrosis.",Idiopathic Pulmonary Fibrosis,0.0,0.95
SLC5A8,SLC6A15,weak,"Based on the provided STRING score of 0.232, there is a weak interaction between SLC5A8 and SLC6A15.  The BioGRID score is 0, and there are no PubMed abstracts, indicating limited evidence for a direct interaction.",,0.0,0.232
SMR3B,STATH,weak,"Limited evidence suggests a potential interaction between SMR3B and STATH, possibly related to salivary gland function, but the exact nature of their interaction is not well-characterized.",Salivary gland tumors,0.0,0.717
TFAP2B,ZIC1,weak,"Based on the provided evidence, there is a weak interaction between TFAP2B and ZIC1. The STRING score is 0.438, which is below the threshold for high confidence.  The BioGRID score is 0, indicating no interaction found in BioGRID. The PubMed abstract mentions neural crest development, a process in which both genes may play a role, but doesn't directly describe their interaction.",Not specified in evidence,0.0,0.438
TF,TTR,weak,"Based on the provided abstracts, there is no direct interaction between TF and TTR.  The STRING score suggests a possible interaction, but this is not supported by BioGRID.  The abstracts discuss TF in the context of cell differentiation and TTR in the context of amyloid fibril formation, indicating no known direct interaction.",No major disease is directly linked based on the evidence provided.,0.0,0.817
UGT2B4,UGT3A1,weak,"Both genes belong to the UDP-glycosyltransferase (UGT) superfamily and are involved in the metabolism of various molecules, suggesting a potential indirect interaction through shared metabolic pathways. However, the STRING and BioGRID scores do not provide strong evidence of a direct interaction.",,0.0,0.273
ERBB4,EREG,strong,"ERBB4 and EREG are involved in epidermal growth factor (EGF) signaling, which regulates various cellular processes and plays a crucial role in tumorigenesis. EREG, as a member of the EGF family, can bind to receptors in the EGFR family, which includes ERBB4, to activate downstream signaling pathways involved in cell proliferation and survival.","Cancer, including cervical cancer",0.124909548940367,0.999
ERBB4,MUC1,weak,"The interaction between ERBB4 and MUC1 is not well-documented in the provided evidence. The STRING score is below the high confidence threshold, and the BioGRID score, while numerically high, lacks context without percentile information. The PubMed abstract does not directly mention an interaction between these genes.",Not specified,0.124909548940367,0.533
ESR1,PDZK1,weak,"ESR1, encoding the estrogen receptor alpha, is known to interact with various proteins in estrogen signaling pathways. PDZK1, a scaffold protein, may play a role in modulating membrane receptor interactions, but the STRING score suggests only a potential indirect or weak interaction.",Breast cancer,0.124909548940367,0.549
ESR1,TFAP2C,strong,"TFAP2C is known to regulate the expression of ESR1, and their interaction is significant in the context of hormone receptor-positive breast cancer.",Breast Cancer,0.18898085217110117,0.938
F13B,F9,weak,"Based on the provided evidence, there is weak evidence to suggest an interaction between F13B and F9. The STRING score is below the high-confidence threshold, and the BioGRID score is 0.  The PubMed abstracts mention coagulation factors and liver production of proteins involved in the immune response, but do not directly describe an interaction between F13B and F9.",,0.0,0.603
FAM3B,INS,weak,"FAM3B (PANDER) is an islet-specific cytokine that may influence beta-cell apoptosis, potentially affecting insulin (INS) production or secretion indirectly.",Diabetes,0.0,0.252
FAT2,NTRK2,weak,"Based on the provided STRING score of 0.29, there is a weak interaction between FAT2 and NTRK2.  The BioGRID score of 0 and lack of PubMed abstracts further support a weak interaction, or a lack of currently known interaction.",,0.0,0.29
FEZF2,NEUROD6,weak,"FEZF2 and NEUROD6 may interact in the context of neural progenitor differentiation and temporal identity transitions, as suggested by the STRING score and PubMed abstract, but direct evidence of interaction is limited.",Neurodevelopmental disorders,0.0,0.751
FGF21,SLC6A19,weak,"FGF21 may influence amino acid metabolism, potentially interacting with SLC6A19, a neutral amino acid transporter, in the context of dietary protein restriction and metabolic health",Metabolic disorders,0.0,0.234
FOXA3,PDX1,weak,"FOXA3 and PDX1 are involved in pancreatic cell differentiation and function, but direct interaction evidence is limited",Diabetes,0.0,0.611
FOXJ1,SCGB3A2,weak,"The interaction between FOXJ1 and SCGB3A2 is suggested to be weak based on the STRING score which is above 0.7, indicating potential interaction. However, the lack of evidence from BioGRID and PubMed abstracts limits the strength of this interaction.",,0.0,0.763
FUT3,FUT6,strong,"FUT3 and FUT6 are both fucosyltransferase enzymes involved in the glycosylation process. They are likely to interact in the context of glycosylation pathways, which play significant roles in various biological processes and diseases.",cancer,0.0,0.924
FUT3,GAL3ST3,weak,"The interaction between FUT3 and GAL3ST3 is not well-documented in the literature or major interaction databases. The high STRING score suggests a potential interaction, but the lack of BioGRID score and PubMed abstracts indicates limited evidence.",Not specified,0.0,0.791
GAD2,NTS,weak,"GAD2 inhibitory neurons are abundant in the nucleus of the solitary tract (NTS), suggesting a potential regulatory role of GAD2 in NTS functions, though direct interaction evidence is limited.",Emotion and energy metabolism disorders,0.0,0.426
GAL3ST1,UGT8,strong,"GAL3ST1 and UGT8 are both involved in the metabolism of glycolipids. GAL3ST1 encodes an enzyme responsible for the sulfation of galactosylceramide, whereas UGT8 is involved in the biosynthesis of cerebrosides, which are a type of glycosphingolipid. Their interaction may play a critical role in lipid metabolism.","Potential involvement in cancer pathogenesis, specifically in neoplasms like IPMNs.",0.0,0.964
GATA4,NR0B1,strong,"GATA4 and NR0B1 are transcription factors involved in sex development and differentiation. GATA4 is known to interact with other factors in the regulation of gene expression relevant to gonadal development, while NR0B1 (also known as DAX1) is involved in adrenal and reproductive function. The STRING score of 0.822 indicates a high-confidence interaction, suggesting these genes might work together in pathways related to reproductive development or disorders.",Differences in sex development (DSD),0.0,0.822
HSD17B2,UGT1A10,strong,"HSD17B2 and UGT1A10 both play roles in steroid metabolism, with HSD17B2 involved in the oxidation of hormones and UGT1A10 facilitating their conjugation and excretion. The interaction is significant in the metabolic pathways related to hormone regulation.",,0.0,0.822
HTN1,HTN3,strong,"HTN1 and HTN3 are both involved in the formation of tooth enamel, indicating a functional relationship in biomineralization processes",Dental enamel defects,0.124909548940367,0.987
INS,RBP4,weak,"The STRING score is below the high-confidence threshold, and the BioGRID score is 0.  PubMed abstracts mention both genes in the context of type 2 diabetes, suggesting a potential indirect relationship through shared involvement in pancreatic beta-cell function and diabetes pathogenesis. However, direct interaction evidence is lacking.",Type 2 Diabetes,0.0,0.675
INS,SST,strong,"Somatostatin (SST) inhibits the secretion of insulin (INS) from pancreatic beta cells, playing a crucial role in glucose homeostasis",Diabetes,0.0,0.953
INS,TTR,weak,"The interaction between INS and TTR is not well-documented in the provided PubMed abstracts, but the high STRING and BioGRID scores suggest a potential biological interaction.",Not specified,0.124909548940367,0.805
KRT18,MUC1,weak,"KRT18 and MUC1 are both involved in epithelial cell structure and function, but direct interaction evidence is limited",Cancer,0.0,0.625
LCE2A,LCE2B,strong,"LCE2A and LCE2B are members of the late cornified envelope (LCE) gene family, which are involved in skin barrier function. Their high STRING and BioGRID scores suggest a strong interaction, possibly in the context of skin differentiation and barrier formation.",Skin diseases,0.124909548940367,0.908
LCE2A,LCE2C,strong,"LCE2A and LCE2C are both members of the late cornified envelope (LCE) gene cluster, which are involved in skin barrier function and response to epidermal stress. Their interaction is likely due to their shared role in skin biology, contributing to processes such as skin repair and protection against pathogens.","skin disorders, possibly including conditions like psoriasis",0.124909548940367,0.913
LCE2A,LCE3A,strong,"LCE2A and LCE3A are members of the late cornified envelope (LCE) gene family, which are involved in skin barrier function and may interact in the formation of the cornified envelope",Psoriasis,0.124909548940367,0.86
LCE2A,LCE3C,weak,"Both LCE2A and LCE3C are part of the late cornified envelope (LCE) gene family, which is involved in skin barrier function. The STRING score suggests a potential interaction, but the lack of BioGRID score and PubMed abstracts limits the evidence.",Psoriasis,0.0,0.786
LCE2B,LCE2C,strong,"LCE2B and LCE2C are closely related genes involved in skin barrier function, with high interaction scores suggesting a strong functional relationship",Skin diseases,0.124909548940367,0.999
LCE2B,LCE3A,strong,"LCE2B and LCE3A are part of the late cornified envelope (LCE) gene cluster, which plays a critical role in skin barrier function. Both genes are expressed in the epidermis and are involved in the formation of the cornified cell envelope, a structure essential for skin barrier protection. Their interaction is crucial in maintaining skin integrity and is implicated in the pathogenesis of skin disorders such as psoriasis and atopic dermatitis.","Psoriasis, Atopic Dermatitis",0.124909548940367,0.828
LCE2B,LCE3C,weak,"LCE2B and LCE3C are both members of the late cornified envelope (LCE) gene family, which is involved in skin barrier function. The interaction strength is considered weak based on the provided evidence.",Psoriasis,0.124909548940367,0.561
LCE2C,LCE3A,strong,"LCE2C and LCE3A are both members of the late cornified envelope (LCE) gene family, which are involved in skin barrier function and are associated with psoriasis. The high STRING and BioGRID scores suggest a strong interaction, likely due to their co-expression and functional similarity in skin differentiation and barrier formation.",Psoriasis,0.124909548940367,0.79
LCE2C,LCE3C,strong,"LCE2C and LCE3C are part of the late cornified envelope (LCE) gene cluster, which plays a crucial role in skin barrier formation and repair. These genes are often co-expressed and may work together in maintaining skin integrity.",Psoriasis,0.0,0.794
LCE3A,LCE3C,strong,"LCE3A and LCE3C are part of the late cornified envelope (LCE) gene family, which is involved in skin barrier function and is associated with psoriasis. The deletion of LCE3C, alongside LCE3B, is linked to increased psoriasis risk, suggesting a functional interaction related to skin disease.",Psoriasis,0.0,0.704
LHX8,NOBOX,strong,"LHX8 and NOBOX are involved in the regulation of oocyte growth and primordial follicle development. They play a crucial role in mammalian reproductive ability, particularly in the formation of the primordial follicle pool.",Ovarian physiology and pathogenesis,0.0,0.927
MAGEA1,S100A9,weak,"The interaction between MAGEA1 and S100A9 is not well-documented in the literature. The STRING score suggests a low confidence interaction, while the BioGRID score, although high, lacks supporting PubMed abstracts to confirm a biological relevance.",Not specified,0.124909548940367,0.239
MLPH,TYR,weak,"Based on the provided abstracts, both genes are involved in melanin production and pigmentation pathways. However, the STRING and BioGRID scores do not show strong direct interaction.  The abstracts suggest a functional relationship in the context of pigmentation, but not necessarily a direct physical interaction.",Hyperpigmentation,0.0,0.567
AADAC,CES1,weak,"Both AADAC and CES1 are hydrolases involved in drug metabolism. They are primarily expressed in the liver and gastrointestinal tract and play roles in hydrolyzing drugs with ester and amide bonds. Their interaction in drug metabolism could potentially result in drug-drug interactions, impacting drug efficacy and safety.",,0.0,0.693
ACE2,AGT,strong,"ACE2 and AGT are involved in the renin-angiotensin system, which plays a crucial role in regulating blood pressure and fluid balance. ACE2 can convert angiotensin II, a product of AGT, into angiotensin-(1-7), a peptide with vasodilatory effects, thereby counteracting the effects of angiotensin II.",Hypertension and cardiovascular diseases,0.18898085217110117,0.999
ACE2,CLDN7,weak,"Based on the provided evidence, there is a weak interaction between ACE2 and CLDN7. The STRING score of 0.257 suggests a weak interaction, while the BioGRID score is 0, indicating no interaction found in BioGRID. The PubMed abstract mentions COVID-19 and smoking, but does not directly link ACE2 and CLDN7.",COVID-19,0.0,0.257
ACE2,CYP11B2,weak,"Based on the provided evidence, there is weak evidence suggesting an interaction between ACE2 and CYP11B2.  The STRING score is below the high-confidence threshold (0.582 < 0.7), and the BioGRID score is 0, indicating no interaction detected in that database.  The PubMed abstracts mention these genes in the context of hypertension, suggesting a possible indirect relationship, but not a direct interaction. More evidence is needed to strengthen the interaction hypothesis.",Hypertension,0.0,0.582
ACE2,PDZK1,strong,"ACE2 interacts with PDZK1 to modulate its stability and localization, impacting the renin-angiotensin system.","Hypertension, COVID-19",0.23239274157331358,0.815
ADH1B,ADH1C,strong,"ADH1B and ADH1C are both part of the alcohol dehydrogenase enzyme family and are known to interact in the metabolism of alcohol. They encode enzymes that convert alcohols to aldehydes, and their interaction is significant in the context of alcohol metabolism.",Alcohol Use Disorder,0.23239274157331358,0.986
ADH1B,ALDH3A1,strong,"ADH1B and ALDH3A1 are both involved in the alcohol metabolism pathway. ADH1B catalyzes the conversion of alcohols to aldehydes, which are then further metabolized by aldehyde dehydrogenases like ALDH3A1. This sequential activity is crucial in the detoxification of alcohols in the body.",Alcohol-related liver disease,0.0,0.857
ADH1B,UGT1A10,weak,"Limited evidence suggests a potential interaction between ADH1B and UGT1A10, but the biological significance remains unclear",Not specified,0.0,0.715
ADH1C,ALDH3A1,weak,"Both ADH1C and ALDH3A1 are involved in the metabolism of ethanol, with ADH1C converting ethanol to acetaldehyde and ALDH3A1 potentially involved in the further metabolism of acetaldehyde, though direct interaction evidence is limited",Alcohol-related diseases,0.0,0.866
ADH1C,UGT1A10,weak,"Limited evidence suggests a potential interaction between ADH1C and UGT1A10, but the biological significance remains unclear",Not specified,0.0,0.711
ADIPOQ,CRP,weak,"ADIPOQ and CRP may interact in metabolic and inflammatory pathways, but direct evidence is limited","Metabolic syndrome, Cardiovascular diseases",0.0,0.882
ADIPOQ,FGF21,weak,"ADIPOQ and FGF21 are both involved in metabolic regulation, but direct interaction evidence is limited",Metabolic syndrome,0.0,0.782
ADIPOQ,SAA2,weak,"Limited evidence suggests a potential link between ADIPOQ and SAA2 in the context of obesity-associated inflammation and insulin resistance, but the interaction is not well-characterized","Obesity, Insulin Resistance",0.0,0.379
AFM,APOC3,weak,"Limited evidence suggests potential interaction in contexts like sepsis and venous thrombosis, but no direct functional interaction is strongly supported","Sepsis, Venous thrombosis",0.0,0.603
AGT,CYP11B2,strong,"AGT encodes angiotensinogen, a precursor of angiotensin II, which is involved in blood pressure regulation. CYP11B2 encodes aldosterone synthase, which catalyzes the synthesis of aldosterone, a hormone that regulates blood pressure. Their interaction is part of the renin-angiotensin-aldosterone system (RAAS), crucial for blood pressure and electrolyte balance.","Hypertension, cardiovascular diseases",0.0,0.899
AKR1C2,UGT2B15,strong,"AKR1C2 and UGT2B15 are involved in steroid metabolism pathways, particularly in the inactivation and clearance of androgens. This interaction is relevant in the context of prostate cancer progression where both genes play a role in modulating androgen levels.",prostate cancer,0.0,0.948
AMBP,ORM2,strong,"Both AMBP and ORM2 are involved in inflammatory responses and are linked to diabetic conditions. AMBP plays a role in the transport and storage of thyroid hormones, while ORM2 is an acute phase protein that modulates the immune response. The STRING score suggests a high-confidence interaction, possibly related to inflammatory pathways in diabetic complications.",Diabetic kidney disease,0.0,0.893
AMBP,PLG,weak,"No direct interaction described in the provided evidence, but high STRING score suggests potential functional association",Not specified,0.0,0.811
AMN,APOA1,weak,"Based on the provided evidence, there is a weak interaction between AMN and APOA1.  The STRING score is above 0.7, suggesting a potential interaction. However, the BioGRID score is 0, and the PubMed abstract mentions differential expression in relation to HDL-C (which APOA1 is associated with) but doesn't explicitly describe a direct interaction between AMN and APOA1.",Coronary Artery Disease,0.0,0.797
APOA1,APOC3,strong,"APOA1 and APOC3 are both apolipoproteins involved in lipid metabolism. APOA1 is a major component of high-density lipoprotein (HDL) and plays a role in cholesterol efflux, while APOC3 is known to inhibit lipoprotein lipase and hepatic lipase, leading to increased triglyceride levels. The interaction between these genes is crucial in lipid metabolism and can influence cardiovascular disease risk.",Cardiovascular diseases,0.18898085217110117,0.999
APOA1,ORM2,weak,"Limited evidence suggests potential interaction between APOA1 and ORM2, possibly related to plasma protein functions, but specific mechanisms are unclear",Not specified,0.0,0.828
APOA1,RBP4,weak,"APOA1 and RBP4 may interact in lipid metabolism and transport processes, but direct evidence is limited","Cardiovascular diseases, Metabolic disorders",0.0,0.814
APOA1,TF,strong,"APOA1 and TF (Transferrin) are found to interact strongly based on high STRING and BioGRID scores. The interaction potentially involves aspects of lipid metabolism and iron transport, though specific functional studies are sparse.","No specific disease directly linked to the interaction between APOA1 and TF, but both genes are involved in metabolic pathways and could be implicated in systemic metabolic disorders.",0.124909548940367,0.919
APOA1,TTR,strong,"APOA1 and TTR are known to interact in the context of amyloidosis. TTR is a carrier protein for thyroxine and retinol-binding protein and can misfold, leading to amyloid fibril formation. APOA1 is an apolipoprotein involved in lipid metabolism and has been implicated in certain types of amyloidosis. Their interaction is significant in the context of amyloid diseases.",amyloidosis,0.124909548940367,0.994
APOB,HRG,weak,"Based on a STRING score of 0.805, there is a potential weak interaction between APOB and HRG.  However, the BioGRID score is 0, and the PubMed abstracts do not provide supporting evidence of a direct interaction. The STRING score alone is not sufficient to classify the interaction as strong.",None identified from provided abstracts,0.0,0.805
APOC3,RBP4,weak,"Based on the provided abstracts, there is mention of both APOC3 and RBP4 in the context of metabolic health, suggesting a potential indirect interaction. However, the STRING score is below the high-confidence threshold (0.582<0.7), and the BioGRID score is 0.  The abstracts do not describe a direct interaction between these genes. Therefore, the interaction strength is classified as weak.",Metabolic disorders,0.0,0.582
APOC3,TTR,weak,"Based on a STRING score of 0.771, there is a suggestion of an interaction. However, the BioGRID score is 0 and the PubMed abstracts do not provide direct evidence of a functional relationship between APOC3 and TTR.  Therefore, the interaction strength is classified as weak.",No major disease is directly indicated by the provided evidence.,0.0,0.771
APOH,CRP,weak,"APOH and CRP may interact in the context of immune response and inflammation, but the evidence is not strong enough to confirm a direct or significant interaction",Inflammation-related diseases,0.0,0.778
APOH,TYR,weak,"The interaction between APOH and TYR is not well-documented in the literature. The STRING score suggests a potential interaction, but the lack of BioGRID score and PubMed abstracts indicates limited evidence.",Not specified,0.0,0.778
AREG,ESR1,weak,"Based on the provided evidence, there is a weak interaction between AREG and ESR1. The STRING score of 0.668 is below the high-confidence threshold of 0.7.  The BioGRID score is 0. The PubMed abstracts do not provide strong evidence of a direct interaction.",,0.0,0.668
BMP7,BMPR1B,strong,"BMP7 is known to bind to and activate BMPR1B, a receptor, initiating signaling pathways involved in bone formation and neurodevelopment.","bone-related diseases, neurodevelopmental disorders",0.18898085217110117,0.999
BMP7,CXCL1,weak,"BMP7 may influence the inflammatory response mediated by CXCL1, particularly in contexts like bone healing and renal damage, but direct interaction evidence is limited.","Bone healing disorders, Renal diseases",0.0,0.187
BMP7,GREM1,strong,"GREM1 is known to antagonize BMP7 activity, which influences processes like bone formation and cellular differentiation.",,0.0,0.911
BMPR1B,GREM1,weak,"Based on the provided abstracts, BMPR1B and GREM1 are both involved in bone morphogenetic protein (BMP) signaling pathways.  GREM1 acts as an antagonist to BMPs, while BMPR1B is a receptor for BMPs. This suggests a potential indirect interaction. However, the STRING and BioGRID scores are low, indicating a lack of strong direct interaction evidence.",No major disease specifically linked from this evidence.,0.0,0.378
CACNG4,GRIA2,strong,"CACNG4 is known to interact with GRIA2, playing a role in the trafficking and stabilization of AMPA receptors, which are critical for synaptic plasticity and learning.",Neurological disorders,0.0,0.907
CCL15,CXCL1,strong,"CCL15 and CXCL1 are both chemokines involved in immune response pathways. Their interaction likely influences inflammatory and immune processes, which can contribute to pathological conditions such as autoimmune disorders and cancer-related inflammation.","autoimmune disorders, cancer-related inflammation",0.0,0.731
CCL21,PAH,weak,"The provided PubMed abstracts suggest a potential link between CCL21 and PAH, particularly in the context of systemic sclerosis (SSc).  However, the STRING and BioGRID scores are low, indicating a lack of direct physical interaction evidence. The abstracts highlight CCL21's role in lung inflammation, which may indirectly relate to PAH in SSc.  More research is needed to establish a definitive interaction.",Systemic Sclerosis,0.0,0.0
CDH1,CLDN7,strong,"CDH1 and CLDN7 are involved in cell-cell adhesion and maintaining epithelial integrity. CDH1, known as E-cadherin, is critical for adherens junctions, while CLDN7 is a component of tight junctions. Their interaction is significant in cellular adhesion processes, which are crucial for epithelial tissue organization and integrity.",Adenomyosis,0.0,0.923
CDH1,ESR1,weak,"Potential epigenetic regulation involving CDH1 and ESR1 in cancer contexts, with limited direct interaction evidence",Cancer,0.0,0.803
CDH1,FOXQ1,weak,"Potential involvement in epithelial-mesenchymal transition (EMT) and cancer metastasis, but direct interaction evidence is limited",Esophageal squamous cell carcinoma (ESCC),0.0,0.354
CDH3,CLDN8,weak,"CDH3 and CLDN8 are involved in cell-cell junction complexes, which are crucial for epithelial tissue organization. Changes in their interactions may be associated with carcinogenesis.",Cancer,0.0,0.236
CES1,UGT2B4,strong,"CES1 and UGT2B4 both play roles in hepatic drug metabolism, with CES1 being a carboxylesterase and UGT2B4 being a UDP-glucuronosyltransferase. Their interaction is likely involved in the metabolism and detoxification processes of various drugs and xenobiotics in the liver.",Liver cirrhosis and drug metabolism disorders,0.0,0.78
CHGB,SCG3,strong,"CHGB and SCG3 are both involved in neuroendocrine processes. While direct interactions are not explicitly detailed, the high STRING score suggests a strong interaction, potentially through shared pathways or similar functions in neuroendocrine tumor biology.",neuroendocrine tumors,0.0,0.937
CLDN18,CLDN8,weak,"Both genes belong to the claudin multigene family, which is involved in physiological and cellular signaling pathways, but direct interaction evidence is limited",Not specified,0.0,0.799
CNTN1,CNTNAP2,weak,"CNTN1 and CNTNAP2 are both involved in neural development and cell adhesion, but direct interaction evidence is limited",Neurological disorders,0.0,0.751
CNTNAP2,DPYSL5,strong,"CNTNAP2 and DPYSL5 are involved in neural development pathways. High STRING score suggests a probable interaction, potentially related to synaptic function or neural signaling pathways, although specific mechanisms may not be fully elucidated.",,0.0,0.825
CRNN,CTNNA2,weak,"Based on a STRING score of 0.307 and a BioGRID score of 0, the interaction between CRNN and CTNNA2 is considered weak.  Further research is needed to confirm this interaction.",,0.0,0.307
CRNN,SERPINB11,weak,"The evidence does not strongly support a direct interaction between CRNN and SERPINB11. The STRING score is low, and there is no support from BioGRID. A PubMed abstract mentions oral cancer, but it does not clearly link these two genes in that context.",oral cancer,0.0,0.232
CRP,CXCL5,weak,"Based on the provided evidence, there is weak interaction between CRP and CXCL5.  The STRING score of 0.392 is below the high confidence threshold, and the BioGRID score is 0. The PubMed abstracts mention inflammation, but do not describe a direct interaction between these two genes.",Inflammation,0.0,0.392
CRP,S100A8,weak,"Based on the provided evidence, there is weak evidence of interaction between CRP and S100A8. The STRING score is 0.367, which is below the threshold for high confidence.  The BioGRID score is 0, indicating no interaction found in that database. While the PubMed abstracts mention both CRP (implied through discussion of inflammation and infection which CRP is involved in) and S100A8 (calprotectin), they do not describe a direct interaction between the two genes.",Inflammation,0.0,0.367
CRP,SAA2,weak,"CRP and SAA2 are both acute-phase proteins involved in inflammatory responses, but direct interaction evidence is limited",Inflammatory diseases,0.0,0.811
CSH1,PSG8,weak,"Limited evidence suggests a potential interaction between CSH1 and PSG8, but the biological significance remains unclear",Not specified,0.0,0.767
CTRB1,CTRB2,strong,"CTRB1 and CTRB2 are both chymotrypsin-like enzymes involved in the digestive process, specifically in the degradation of trypsinogen to protect the pancreas. Their high interaction scores suggest a functional relationship or co-regulation in pancreatic protection mechanisms.",Pancreatic diseases,0.124909548940367,0.949
CTRB1,PNLIP,strong,"CTRB1 and PNLIP are both pancreatic enzymes involved in the digestion of dietary fats and proteins. Their high STRING score suggests a strong functional association, likely in the context of pancreatic exocrine function.",Pancreatic disorders,0.0,0.925
CTRB2,PNLIP,strong,"CTRB2 and PNLIP are both pancreatic enzymes involved in the digestion of dietary fats and proteins, with potential functional interactions in the digestive process",Pancreatic disorders,0.0,0.856
CXCL1,CXCL5,strong,CXCL1 and CXCL5 are both chemokines involved in inflammatory responses and are known to play roles in cancer progression and other inflammatory diseases.,"lung cancer, COPD, gestational diabetes mellitus",0.124909548940367,0.999
CXCL1,S100A8,weak,"The interaction between CXCL1 and S100A8 is suggested by a moderate STRING score, but lacks strong supporting evidence from BioGRID or specific PubMed abstracts detailing their direct interaction.","Inflammatory diseases, Cancer",0.0,0.601
CYP2B6,CYP4A22,weak,"The interaction between CYP2B6 and CYP4A22 is suggested by a high STRING score, indicating potential functional association, but lacks supporting evidence from BioGRID and PubMed abstracts.",Not specified,0.0,0.945
CYP2B6,GSTA3,weak,"No known direct interaction between CYP2B6 and GSTA3, but both are involved in drug metabolism pathways",Drug metabolism disorders,0.0,0.733
CYP2B6,UGT2B15,strong,"CYP2B6 and UGT2B15 are both involved in the metabolism of drugs and endogenous compounds in the liver. Their interaction is crucial for understanding the pharmacokinetics and pharmacodynamics of various substances, including the impact of alcohol on drug metabolism.",,0.0,0.883
CYP2C18,UGT1A10,strong,"CYP2C18 and UGT1A10 are involved in drug metabolism pathways. CYP2C18 is part of the cytochrome P450 family, which is involved in the oxidation of organic substances, while UGT1A10 is part of the UDP-glucuronosyltransferases family, which is involved in glucuronidation, a major phase II drug metabolism process. Their interaction is important for the metabolism and clearance of various drugs and xenobiotics.",Drug metabolism disorders,0.0,0.841
CYP4A22,UGT2B15,weak,"Genetic polymorphisms in CYP4A22 and UGT2B15 may influence endocrine regulation or drug metabolism, but direct interaction evidence is limited.",Drug metabolism disorders,0.0,0.747
CYP4B1,HSD17B2,weak,"Based on the provided evidence, there is a weak interaction between CYP4B1 and HSD17B2. The STRING score is 0.225, which is below the threshold for high confidence.  The BioGRID score is 0, indicating no interaction in that database.  PubMed abstract 27189315 mentions both genes in the context of placental steroid metabolism, suggesting a potential indirect or functional relationship, but this is not conclusive evidence of a direct interaction. More evidence is needed to determine the precise nature and strength of any interaction.",,0.0,0.225
EEF1A2,MUC1,strong,"Based on the STRING score of 0.775, which indicates a high confidence level, there is a likely interaction between EEF1A2 and MUC1. Although no direct interaction evidence is found in BioGRID, the STRING score suggests a functional or physical interaction between these genes.",lung cancer,0.0,0.775