diff --git a/Dockerfile.django-alpine b/Dockerfile.django-alpine
index 828a15b786f..a92f95fc46a 100644
--- a/Dockerfile.django-alpine
+++ b/Dockerfile.django-alpine
@@ -11,26 +11,17 @@ WORKDIR /app
 RUN \
   apk update && \
   apk add --no-cache \
-    gcc \
-    build-base \
     bind-tools \
     postgresql16-client \
     xmlsec \
     git \
     util-linux \
-    curl-dev \
     openssl \
-    libffi-dev \
-    python3-dev \
-    libpq-dev \
     && \
     rm -rf /var/cache/apk/* && \
   true
 COPY requirements.txt ./
-# CPUCOUNT=1 is needed, otherwise the wheel for uwsgi won't always be build succesfully
-# https://github.com/unbit/uwsgi/issues/1318#issuecomment-542238096
-RUN export PYCURL_SSL_LIBRARY=openssl && \
-    CPUCOUNT=1 pip3 wheel --wheel-dir=/tmp/wheels -r ./requirements.txt
+RUN pip3 wheel --wheel-dir=/tmp/wheels -r ./requirements.txt
 
 FROM base AS release
 WORKDIR /app
@@ -49,8 +40,9 @@ RUN \
     git \
     util-linux \
     postgresql16-client \
-    curl-dev \
     openssl \
+    # py3-curl for Celery SQS broker support (avoids compilation)
+    py3-curl \
     # needed for integration-tests
     bash \
     && \
@@ -65,6 +57,16 @@ RUN \
   --find-links=/tmp/wheels \
   -r ./requirements.txt
 
+# Install uwsgi via pip for Alpine (system package is compiled for Python 3.12, but we use Python 3.13)
+# uwsgi needs build dependencies to compile
+RUN apk add --no-cache --virtual .uwsgi-build-deps \
+    gcc \
+    musl-dev \
+    linux-headers \
+    python3-dev \
+    && pip3 install --no-cache-dir uwsgi==2.0.28 \
+    && apk del .uwsgi-build-deps
+
 COPY \
   docker/entrypoint-celery-beat.sh \
   docker/entrypoint-celery-worker.sh \
diff --git a/Dockerfile.django-debian b/Dockerfile.django-debian
index 779dbcba13d..12d3602d163 100644
--- a/Dockerfile.django-debian
+++ b/Dockerfile.django-debian
@@ -11,25 +11,17 @@ WORKDIR /app
 RUN \
   apt-get -y update && \
   apt-get -y install --no-install-recommends \
-    gcc \
-    build-essential \
     dnsutils \
-    libpq-dev \
     postgresql-client \
     xmlsec1 \
     git \
     uuid-runtime \
-    # libcurl4-openssl-dev is required for installing pycurl python package
-    libcurl4-openssl-dev \
     && \
   apt-get clean && \
   rm -rf /var/lib/apt/lists && \
   true
 COPY requirements.txt ./
-# CPUCOUNT=1 is needed, otherwise the wheel for uwsgi won't always be build succesfully
-# https://github.com/unbit/uwsgi/issues/1318#issuecomment-542238096
-RUN export PYCURL_SSL_LIBRARY=openssl && \
-    CPUCOUNT=1 pip3 wheel --wheel-dir=/tmp/wheels -r ./requirements.txt
+RUN pip3 wheel --wheel-dir=/tmp/wheels -r ./requirements.txt
 
 FROM base AS release
 WORKDIR /app
@@ -50,11 +42,13 @@ RUN \
     xmlsec1 \
     git \
     uuid-runtime \
-    libpq-dev \
     # only required for the dbshell (used by the initializer job)
     postgresql-client \
-    # libcurl4-openssl-dev is required for installing pycurl python package
-    libcurl4-openssl-dev \
+    # python3-pycurl for Celery SQS broker support (avoids compilation)
+    python3-pycurl \
+    # uwsgi from system packages (avoids compilation)
+    uwsgi \
+    uwsgi-plugin-python3 \
     && \
   apt-get clean && \
   rm -rf /var/lib/apt/lists && \
diff --git a/Dockerfile.nginx-alpine b/Dockerfile.nginx-alpine
index bfdf4a4114a..8be00a5814d 100644
--- a/Dockerfile.nginx-alpine
+++ b/Dockerfile.nginx-alpine
@@ -11,31 +11,24 @@ WORKDIR /app
 RUN \
   apk update && \
   apk add --no-cache \
-    gcc \
-    build-base \
     bind-tools \
     postgresql16-client \
     xmlsec \
     git \
     util-linux \
-    curl-dev \
     openssl \
-    libffi-dev \
-    python3-dev \
-    libpq-dev \
     && \
     rm -rf /var/cache/apk/* && \
   true
 COPY requirements.txt requirements-dev.txt ./
-# CPUCOUNT=1 is needed, otherwise the wheel for uwsgi won't always be build succesfully
-# https://github.com/unbit/uwsgi/issues/1318#issuecomment-542238096
-RUN CPUCOUNT=1 pip3 wheel --wheel-dir=/tmp/wheels -r ./requirements.txt
+RUN pip3 wheel --wheel-dir=/tmp/wheels -r ./requirements.txt
 # needed for static files debug toolbar
-RUN CPUCOUNT=1 pip3 wheel --wheel-dir=/tmp/wheels -r ./requirements-dev.txt
+RUN pip3 wheel --wheel-dir=/tmp/wheels -r ./requirements-dev.txt
 
 
 FROM build AS collectstatic
-RUN apk add nodejs npm
+# py3-curl for Celery SQS broker support (avoids compilation)
+RUN apk add nodejs npm py3-curl
 RUN npm install -g yarn --force
 
 
diff --git a/docker-compose.override.dev.yml b/docker-compose.override.dev.yml
index bc31139a352..d3d3a3cd4c1 100644
--- a/docker-compose.override.dev.yml
+++ b/docker-compose.override.dev.yml
@@ -3,7 +3,7 @@ services:
   uwsgi:
     build:
       context: .
-      dockerfile: Dockerfile.django-debian
+      dockerfile: Dockerfile.django-${DEFECT_DOJO_OS:-debian}
       target: development
     entrypoint: ['/wait-for-it.sh', '${DD_DATABASE_HOST:-postgres}:${DD_DATABASE_PORT:-5432}', '-t', '30', '--', '/entrypoint-uwsgi-dev.sh']
     volumes:
diff --git a/docker/entrypoint-uwsgi-dev.sh b/docker/entrypoint-uwsgi-dev.sh
index 7051ccadc00..b54ace14453 100755
--- a/docker/entrypoint-uwsgi-dev.sh
+++ b/docker/entrypoint-uwsgi-dev.sh
@@ -31,10 +31,21 @@ watchmedo shell-command \
   /app/dojo &
 
 
-exec uwsgi \
+echo -n "Starting uwsgi"
+
+# Only use --home on Debian; pip-installed uwsgi on Alpine doesn't need it
+if [ ! -f /etc/alpine-release ]; then
+  UWSGI_HOME_OPT="--home /usr/local"
+else
+  UWSGI_HOME_OPT=""
+fi
+
+uwsgi \
   "--${DD_UWSGI_MODE}" "${DD_UWSGI_ENDPOINT}" \
   --protocol uwsgi \
-  --wsgi dojo.wsgi:application \
+  --plugin python3 \
+  ${UWSGI_HOME_OPT} \
+  --module dojo.wsgi:application \
   --enable-threads \
   --processes "${DD_UWSGI_NUM_OF_PROCESSES:-4}" \
   --threads "${DD_UWSGI_NUM_OF_THREADS:-4}" \
diff --git a/docker/entrypoint-uwsgi.sh b/docker/entrypoint-uwsgi.sh
index a9ca7bf49e6..b5cb82ece7f 100755
--- a/docker/entrypoint-uwsgi.sh
+++ b/docker/entrypoint-uwsgi.sh
@@ -34,13 +34,24 @@ if [ -n "${DD_UWSGI_MAX_FD}" ]; then
     DD_UWSGI_EXTRA_ARGS="${DD_UWSGI_EXTRA_ARGS} --max-fd ${DD_UWSGI_MAX_FD}"
 fi
 
-exec uwsgi \
+echo -n "Starting uwsgi"
+
+# Only use --home on Debian; pip-installed uwsgi on Alpine doesn't need it
+if [ ! -f /etc/alpine-release ]; then
+  UWSGI_HOME_OPT="--home /usr/local"
+else
+  UWSGI_HOME_OPT=""
+fi
+
+uwsgi \
   "--${DD_UWSGI_MODE}" "${DD_UWSGI_ENDPOINT}" \
   --protocol uwsgi \
+  --plugin python3 \
+  ${UWSGI_HOME_OPT} \
+  --module dojo.wsgi:application \
   --enable-threads \
   --processes "${DD_UWSGI_NUM_OF_PROCESSES:-4}" \
   --threads "${DD_UWSGI_NUM_OF_THREADS:-4}" \
-  --wsgi dojo.wsgi:application \
   --buffer-size="${DD_UWSGI_BUFFER_SIZE:-8192}" \
   --http 0.0.0.0:8081 --http-to "${DD_UWSGI_ENDPOINT}" \
   --logformat "${DD_UWSGI_LOGFORMAT:-$DD_UWSGI_LOGFORMAT_DEFAULT}" \
diff --git a/requirements.txt b/requirements.txt
index 4b57e450d82..10f624011f7 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -29,14 +29,17 @@ lxml==6.0.2
 Markdown==3.10
 openpyxl==3.1.5
 Pillow==12.0.0  # required by django-imagekit
-psycopg[c]==3.3.2
+psycopg[binary]==3.3.2
 cryptography==46.0.3
 python-dateutil==2.9.0.post0
 redis==7.1.0
 requests==2.32.5
 sqlalchemy==2.0.45  # Required by Celery broker transport
 urllib3==2.6.2
-uWSGI==2.0.31
+# uWSGI is installed via system packages on Debian (uwsgi + uwsgi-plugin-python3) to avoid compilation.
+# On Alpine, uwsgi is installed via pip because the system package (uwsgi-python3) is compiled for Python 3.12
+# but the container uses Python 3.13.7 from the official Python Docker image.
+# uwsgi==2.0.28
 vobject==0.9.9
 whitenoise==5.2.0
 titlecase==2.4.1
@@ -62,7 +65,8 @@ drf-spectacular-sidecar==2025.12.1
 django-ratelimit==4.1.0
 argon2-cffi==25.1.0
 blackduck==1.1.3
-pycurl==7.45.7  # Required for Celery Broker AWS (SQS) support
+# pycurl is required for Celery SQS broker support but is installed via system
+# packages (python3-pycurl on Debian, py3-curl on Alpine) to avoid compilation
 boto3==1.41.5  # Required for Celery Broker AWS (SQS) support
 netaddr==1.3.0
 vulners==3.1.3